Abstract: Fc regions comprising modification to increase the affinity of association between the Fc region and TRIM21 are disclosed. Also disclosed are constituent polypeptides of such Fc regions, antigen-binding molecules and immunogens comprising such Fc regions, and nucleic acids encoding and methods using such Fc regions, antigen-binding molecules and immunogens.

Abstract: A system, according to some example embodiments, includes a commerce database storing item data for a plurality of items offered for sale. A search criteria database stores search criteria associated with a user, the search criteria including search frequency information indicating frequency of a search update to be performed using the search criteria. A search server operation retrieves the search criteria from the search criteria database and performs an update search of the commerce database, the search being performed using the search criteria and in accordance with the search frequency information. A notification engine operationally identifies an update to a previous search result based on the update search and generates a notification of the update to the previous search result.

Abstract: A method and system for automatically updating searches are described. In one embodiment, a first search result may be compared with a second search result to automatically identify at least one data item within the first search result that is changed relative to the second search result. The at least one data item may comprise a transaction term. A notification of the at least one data item may be transmitted to a user device.

Abstract: A method and system for automatically updating searches are described. In one embodiment, a first search result may be compared with a second search result to automatically identify at least one data item within the first search result that is changed relative to the second search result. The at least one data item may comprise a transaction term. A notification of the at least one data item may be transmitted to a user device.

Abstract: A method and system for automatically updating searches are described. In one embodiment, a first search result may be compared with a second search result to automatically identify at least one data item within the first search result that is changed relative to the second search result. The at least one data item may comprise a transaction term. A notification of the at least one data item may be transmitted to a user device.

Abstract: A method and system for automatically updating searches are described. In one embodiment, a first search result may be compared with a second search result to automatically identify at least one data item within the first search result that is changed relative to the second search result. The at least one data item may comprise a transaction term. A notification of the at least one data item may be transmitted to a user device.

Abstract: A method and system for automatically updating searches are described. In one embodiment, a first search result may be compared with a second search result to automatically identify at least one data item within the first search result that is changed relative to the second search result. The at least one data item may comprise a transaction term. A notification of the at least one data item may be transmitted to a user device.

Abstract: A method and system for automatically updating searches are described. In one embodiment, a first search result may be compared with a second search result to automatically identify at least one data item within the first search result that is changed relative to the second search result. The at least one data item may comprise a transaction term. A notification of the at least one data item may be transmitted to a user device.

Abstract: A method and system for automatically updating searches are described. In one embodiment, a first search result may be compared with a second search result to automatically identify from the first search result at least one data item that is new or modified as compared to the second search result. The first search result may comprise a first set of data items satisfying a first set of user-specific search criteria, and the second search result may comprise a second set of data items satisfying a second set of user-specific search criteria. A notification of a result of the comparing may be sent to a user device.

Abstract: A method and system for automatically updating searches are described. In one embodiment, a first search result may be compared with a second search result to automatically identify from the first search result at least one data item that is new or modified as compared to the second search result. The first search result may comprise a first set of data items satisfying a first set of user-specific search criteria, and the second search result may comprise a second set of data items satisfying a second set of user-specific search criteria. A notification of a result of the comparing may be sent to a user device.

Abstract: A method and system for updating searches on an online auction site are described. In one embodiment, a database of auction postings is automatically searched based upon at least one search criteria to produce at least one new search result. The at least one new search result is compared with at least one previous search result. In addition, an e-mail notification of the result of the comparison is sent to a user notifying a user of the comparison.

Abstract: A method and system for updating searches on an online auction site are described. In one embodiment, a database of auction postings is automatically searched based upon at least one search criteria to produce at least one new search result. The at least one new search result is compared with at least one previous search result. In addition, an e-mail notification of the result of the comparison is sent to a user notifying a user of the comparison.

Abstract: A method and system for updating searches on an online auction site are described. In one embodiment, a database of auction postings is automatically searched based upon at least one search criteria to produce at least one new search result. The at least one new search result is compared with at least one previous search result. In addition, an e-mail notification of the result of the comparison is sent to a user notifying a user of the comparison.