Patents by Inventor Patrick Di Giorgio

Patrick Di Giorgio has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PEPTIDE MACROCYCLES AGAINST ACINETOBACTER BAUMANNII
    Publication number: 20240050516
    Abstract: The present invention provides compounds of formula (I) wherein X1, X2, R1 to R6 and A are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of diseases and infections caused by bacteria.
    Type: Application
    Filed: October 12, 2023
    Publication date: February 15, 2024
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Konrad BLEICHER, Daniella CHEANG, Patrick DI GIORGIO, Taishan HU, Christian JENNY, Patrizio MATTEI, Petra SCHMITZ, Theodor STOLL
  • Peptide macrocycles against
    Patent number: 11819532
    Abstract: The present invention provides compounds of formula (I) wherein X1, X2, R1 to R6 and A are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of diseases and infections caused by bacteria.
    Type: Grant
    Filed: April 19, 2019
    Date of Patent: November 21, 2023
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Konrad Bleicher, Daniella Cheang, Patrick Di Giorgio, Patrizio Mattei, Petra Schmitz, Theodor Stoll
  • Bicyclic compounds as ATX inhibitors
    Patent number: 11673888
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, W, A, X, m and n are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: September 28, 2020
    Date of Patent: June 13, 2023
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jérôme Hert, Daniel Hunziker, Patrizio Mattei, Markus Rudolph, Petra Schmitz, Patrick Di Giorgio
  • Peptide macrocycles against
    Patent number: 11505573
    Abstract: The present invention provides compounds of formula (I) wherein X, L1 and R1 to R10 are as described herein, as well as pharmaceutically acceptable salts thereof. Further the present invention is concerned with the manufacture of the compounds of formula (I), pharmaceutical compositions comprising them and their use as medicaments for the treatment of diseases and infections caused by Acinetobacter baumannii.
    Type: Grant
    Filed: March 19, 2019
    Date of Patent: November 22, 2022
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Konrad Bleicher, Daniella Cheang, Patrick Di Giorgio, Taishan Hu, Patrizio Mattei, Petra Schmitz, Theodor Stoll
  • Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
    Patent number: 11098048
    Abstract: Compounds of formula (I) wherein R1, R2, A, W, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds as autotaxin inhibitors.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: August 24, 2021
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Patrick Di Giorgio, Jerome Hert, Daniel Hunziker, Holger Kuehne, Patrizio Mattei, Markus Rudolph
  • Heterocyclic compounds useful as dual ATX/CA inhibitors
    Patent number: 11059794
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, X, W, m and n are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: September 12, 2019
    Date of Patent: July 13, 2021
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Patrizio Mattei, Jérôme Hert, Daniel Hunziker, Markus Rudolph, Petra Schmitz, Patrick Di Giorgio, Justin Gomme
  • OCTAHYDRO-CYCLOBUTA[1,2-c;3,4-c']DIPYRROL-2-YL
    Publication number: 20210015792
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, Y and R2 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: September 28, 2020
    Publication date: January 21, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Patrizio MATTEI, Daniel HUNZIKER, Patrick DI GIORGIO, Jerome HERT, Markus RUDOLPH, Lisha WANG
  • BICYCLIC COMPOUNDS AS ATX INHIBITORS
    Publication number: 20210009589
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, W, A, X, m and n are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: September 28, 2020
    Publication date: January 14, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Jérôme HERT, Daniel HUNZIKER, Patrizio MATTEI, Markus RUDOLPH, Petra SCHMITZ, Patrick DI GIORGIO
  • Bicyclic compounds as ATX inhibitors
    Patent number: 10882857
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, W, A, X, m and n are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: September 12, 2019
    Date of Patent: January 5, 2021
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Jérôme Hert, Daniel Hunziker, Patrizio Mattei, Markus Rudolph, Petra Schmitz, Patrick Di Giorgio
  • Octahydro-cyclobuta[1,2-c;3,4-c?]dipyrrol-2-yl
    Patent number: 10849881
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, Y and R2 are as described herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: December 1, 2020
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Patrizio Mattei, Daniel Hunziker, Patrick Di Giorgio, Jerome Hert, Markus Rudolph, Lisha Wang
  • Bicyclic compounds as ATX inhibitors
    Patent number: 10800786
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, W, m, n, p and q are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: October 13, 2020
    Assignee: Hoffman-La Roche Inc.
    Inventors: Patrizio Mattei, Jerome Hert, Daniel Hunziker, Markus Rudolph, Petra Schmitz, Patrick Di Giorgio
  • Bicyclic compounds as ATX inhibitors
    Patent number: 10787459
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R9, Y, W, m, n, p and q are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: April 10, 2019
    Date of Patent: September 29, 2020
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Patrick Di Giorgio, Jerome Hert, Daniel Hunziker, Patrizio Mattei, Markus Rudolph, Petra Schmitz
  • BICYCLIC COMPOUNDS AS DUAL ATX/CA INHIBITORS
    Publication number: 20200223854
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, W, m, n, p and q are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: March 27, 2020
    Publication date: July 16, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Patrick DI GIORGIO, Jerome HERT, Daniel HUNZIKER, Patrizio MATTEI, Markus RUDOLPH, Petra SCHMITZ, Christoph ULLMER
  • BICYCLIC COMPOUNDS AS AUTOTAXIN (ATX) AND LYSOPHOSPHATIDIC ACID (LPA) PRODUCTION INHIBITORS
    Publication number: 20200216457
    Abstract: Compounds of formula (I) wherein R1, R2, A, W, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds as autotaxin inhibitors.
    Type: Application
    Filed: March 23, 2020
    Publication date: July 9, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Patrick DI GIORGIO, Jerome HERT, Daniel HUNZIKER, Holger KUEHNE, Patrizio MATTEI, Markus RUDOLPH
  • Bicyclic compounds as autotaxin (ATX) and lysophosphatidic acid (LPA) production inhibitors
    Patent number: 10654857
    Abstract: Compounds of formula (I) wherein R1, R2, A, W, m, n, p and q are as described herein, compositions including the compounds and methods of using the compounds as autotaxin inhibitors.
    Type: Grant
    Filed: December 19, 2018
    Date of Patent: May 19, 2020
    Assignee: Hoffman-La Roche Inc.
    Inventors: Patrick Di Giorgio, Jerome Hert, Daniel Hunziker, Holger Kuehne, Patrizio Mattei, Markus Rudolph
  • Bicyclic compounds as dual ATX/CA inhibitors
    Patent number: 10647719
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, W, m, n, p and q are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: May 12, 2020
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Patrick Di Giorgio, Jerome Hert, Daniel Hunziker, Patrizio Mattei, Markus Rudolph, Petra Schmitz, Christoph Ullmer
  • BICYCLIC COMPOUNDS AS ATX INHIBITORS
    Publication number: 20200087307
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, W, m, n, p and q are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: April 10, 2019
    Publication date: March 19, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Patrizio Mattei, Jerome Hert, Daniel Hunziker, Markus Rudolph, Petra Schmitz, Patrick Di Giorgio
  • NEW BICYCLIC COMPOUNDS AS ATX INHIBITORS
    Publication number: 20200079779
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, R9, Y, W, m, n, p and q are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: April 10, 2019
    Publication date: March 12, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Patrick Di Giorgio, Jerome Hert, Daniel Hunziker, Patrizio Mattei, Markus Rudolph, Petra Schmitz
  • HETEROCYCLIC COMPOUNDS USEFUL AS DUAL ATX/CA INHIBITORS
    Publication number: 20200002297
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, X, W, m and n are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: September 12, 2019
    Publication date: January 2, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Patrizio MATTEI, Jérôme HERT, Daniel HUNZIKER, Markus RUDOLPH, Petra SCHMITZ, Patrick DI GIORGIO, Justin GOMME
  • BICYCLIC COMPOUNDS AS ATX INHIBITORS
    Publication number: 20200002336
    Abstract: The invention provides novel compounds having the general formula (I) wherein R1, R2, Y, W, A, X, m and n are as defined herein, compositions including the compounds and methods of using the compounds.
    Type: Application
    Filed: September 12, 2019
    Publication date: January 2, 2020
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Jérôme HERT, Daniel HUNZIKER, Patrizio MATTEI, Markus RUDOLPH, Petra SCHMITZ, Patrick DI GIORGIO