Patents by Inventor Patrick H. C. Van Berkel

Patrick H. C. Van Berkel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant production of mixtures of antibodies
    Publication number: 20110177073
    Abstract: Provided is methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention suitably comprise identical light chains paired to different heavy chains capable of pairing to the light chain, thereby forming functional antigen-binding domains. Mixtures of the recombinantly produced antibodies are also provided by the invention. Such mixtures can be used in a variety of fields.
    Type: Application
    Filed: March 4, 2011
    Publication date: July 21, 2011
    Inventors: Patrick H. C. Van Berkel, Ronald Hendrik Peter Brus, Ton Logtenberg, Abraham Bout
  • Recombinant production of mixtures of antibodies
    Patent number: 7932360
    Abstract: The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention suitably comprise identical light chains paired to different heavy chains capable of pairing to the light chain, thereby forming functional antigen-binding domains. Mixtures of the recombinantly produced antibodies are also provided by the invention. Such mixtures can be used in a variety of fields.
    Type: Grant
    Filed: November 6, 2006
    Date of Patent: April 26, 2011
    Assignee: Merus B.V.
    Inventors: Patrick H. C. Van Berkel, Ronald Hendrik Peter Brus, Ton Logtenberg, Abraham Bout
  • Recombinant production of mixtures of antibodies
    Patent number: 7927834
    Abstract: The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention suitably comprise identical light chains paired to different heavy chains capable of pairing to the light chain, thereby forming functional antigen-binding domains. Mixtures of the recombinantly produced antibodies are also provided by the invention. Such mixtures can be used in a variety of fields.
    Type: Grant
    Filed: July 29, 2008
    Date of Patent: April 19, 2011
    Assignee: Merus B.V.
    Inventors: Patrick H. C. Van Berkel, Ronald Hendrik Peter Brus, Ton Logtenberg, Abraham Bout
  • Recombinant production of mixtures of antibodies
    Publication number: 20090263864
    Abstract: The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention suitably comprise identical light chains paired to different heavy chains capable of pairing to the light chain, thereby forming functional antigen-binding domains. Mixtures of the recombinantly produced antibodies are also provided by the invention. Such mixtures can be used in a variety of fields.
    Type: Application
    Filed: July 29, 2008
    Publication date: October 22, 2009
    Inventors: Patrick H. C. Van Berkel, Ronald Hendrik Peter Brus, Ton Logtenberg, Abraham Bout
  • Recombinant production of mixtures of antibodies
    Patent number: 7429486
    Abstract: The invention provides methods for producing mixtures of antibodies from a single host cell clone, wherein, a nucleic acid sequence encoding a light chain and nucleic acid sequences encoding different heavy chains are expressed in a recombinant host cell. The recombinantly produced antibodies in the mixtures according to the invention suitably comprise identical light chains paired to different heavy chains capable of pairing to the light chain, thereby forming functional antigen-binding domains. Mixtures of the recombinantly produced antibodies are also provided by the invention. Such mixtures can be used in a variety of fields.
    Type: Grant
    Filed: November 6, 2006
    Date of Patent: September 30, 2008
    Assignee: Crucell Holland B.V.
    Inventors: Patrick H. C. Van Berkel, Ronald H. P. Brus, Ton Logtenberg, Abraham Bout
  • Antimicrobial activity of the first cationic cluster of human lactoferrin
    Patent number: 7060677
    Abstract: The present invention provides polypeptides related to human lactoferrin protein that have utility in a variety of therapeutic and prophylactic applications, including use as antimicrobial agents. The invention further provides pharmaceutical compositions containing these polypeptides and therapeutic methods using such compositions. Methods for detecting antimicrobial infections using the polypeptides are also provided.
    Type: Grant
    Filed: November 10, 2000
    Date of Patent: June 13, 2006
    Assignee: AM-Pharma B.V.
    Inventors: Patrick H. C. Van Berkel, Peter Hendikus Nibbering, Jan Henricus Nuijens