Abstract: The presently disclosed subject matter relates to methods and compositions for protecting cells and or tissues from damage due to ischemia. In particular, the presently disclosed subject matter relates to the protective action of cyclin dependent kinase 4/6 (CDK4/6) inhibitors administered to subjects that have been exposed to, or that are at risk of, ischemia.

Abstract: The presently disclosed subject matter relates to methods and compositions for protecting healthy cells from damage due to DNA damaging agents. In particular, the presently disclosed subject matter relates to the protective action of selective cyclin dependent kinase 4/6 (CDK4/6) inhibitors administered to subjects that have been exposed to or that are at risk of exposure to DNA damage.

Abstract: The presently disclosed subject matter relates to methods and compositions for protecting healthy cells from damage due to DNA damaging agents. In particular, the presently disclosed subject matter relates to the protective action of selective cyclin dependent kinase 4/6 (CDK4/6) inhibitors administered to subjects that have been exposed to or that are at risk of exposure to DNA damage.

Abstract: The presently disclosed subject matter relates to methods and compositions for protecting healthy cells from damage due to DNA damaging agents. In particular, the presently disclosed subject matter relates to the protective action of selective cyclin dependent kinase 4/6 (CDK4/6) inhibitors administered to subjects that have been exposed to or that are at risk of exposure to DNA damage.

Abstract: Methods for reducing or preventing the effects of cytotoxic compounds in healthy cells are provided. The methods relate to the use of selective cyclin-dependent kinase (CDK) 4/6 inhibitors to induce transient quiescence in CDK4/6 dependent cells, such as hematopoietic stem cells and/or hematopoietic progenitor cells. Also described is a method of selecting compounds for reducing or preventing the effects of cytotoxic agents compounds in healthy cells.

Abstract: An apparatus is provided for use in a method of making a torque converter clutch. The torque converter clutch is comprised of an annular clutch plate to which is secured or bonded an annular friction surface. The annular friction surface is formed on the machine by die-stamping, from a flat sheet of friction material, successive arcuate segments. Each arcuate segment is stamped into a holding ring which is indexed to accept the next successive segment until a full annulus is provided. The holding ring is transported to a stripper station. Simultaneous with the stamping, the annular clutch plate is heated and transported to the stripper station. When both components are in the stripper station, the friction annulus is stripped from the holding ring onto the heated clutch plate. The clutch plate and attached friction annulus are discharged from the machine. Simultaneous with the stamping, the offal of the sheet of friction material is cut transversely and longitudinally for discharge into an egress channel.

Abstract: A new form of commercially produced moccasin-type shoe comprises an outer wedge sole of crepe rubber, an under vamp of soft leather extending under the whole area of the foot and turned up to form a continuous unseamed rim all around the shoe, and an upper vamp, quarters and a counter hand-stitched to the rim to form an upper. The hand stitching is a form of blanket stitching designed to hold the overlapping top edge of the rim tightly against the other pieces of the upper. The stitching comprises a continuous row of stitches parallel to the top edge of the rim and a series of loop stitches perpendicular to the top edge of the rim.