Abstract: A process for the manufacture of the calcium salt of (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid, useful as an HMGCoA reductase inhibitor, from a compound of the formula (7) wherein A is an acetal or ketal protecting group and R is alkyl, via isolated crystalline compounds of the formula (8) or of formula (10) is described. Crystalline intermediates of formulae 7, 8 and 10 are also described.

Abstract: Processes for the preparation of 4-(3-chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline, salts thereof, and the intermediates used in the process are described.

Abstract: 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one as crystalline Form A.

Abstract: Processes for the preparation of 4-(3-chloro-2-fluoroanilino)-7-methoxy-6-{[1-(N-methylcarbamoylmethyl)piperidin-4-yl]oxy}quinazoline, salts thereof, and the intermediates used in the process are described.

Abstract: A process for the manufacture of the calcium salt of (E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl](3R,5S)-3,5-dihydroxyhept-6-enoic acid, useful as an HMGCoA reductase inhibitor, from a compound of the formula (7) wherein A is an acetal or ketal protecting group and R is alkyl, via isolated crystalline compounds of the formula (8) or of formula (10) is described. Crystalline intermediates of formulae 7, 8 and 10 are also described.

Abstract: A process for preparing an intermediate compound of formula (II) where X is as defined in the specification, R1 is haloalkyl, alkyl, alkenyl, cycloalkyl, carboxyalkyl, alkoxycarbonylalkyl, aryl or arylalkyl; R2, R3, R4 and R5 are organic groups as defined in the specification, which process comprises aromatisation of a compound of formula (III) where R1, R2, R3, n, X and R5 are as defined in relation to formula (II) and R4? is a group R4 or a precursor group thereof, and thereafter if necessary or desired, carrying out one or more of the following steps: (i) removing any hydroxy-protecting groups R; (ii) converting a precursor group R4? to a group R4, or where R4? is a group R4, converting it to a different such group. Compounds obtained are useful intermediates for example in the preparation of fulvestrant. Novel intermediates are also claimed.

Abstract: 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one as crystalline Form A.

Abstract: 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one as crystalline Form A.

Abstract: 4-[3-(4-cyclopropanecarbonyl-piperazine-1-carbonyl)-4-fluoro-benzyl]-2H-phthalazin-1-one as crystalline Form A.

Abstract: A car seat has a support base configured to test on a dedicated seat of a vehicle when installed. The car seat also has a seat shell coupled to the support base that defines a seating surface of the car seat. The seating surface has a seat bottom portion that terminates at a front end of the seat shell. The seat shell is adjustable to a plurality of selectable seat recline orientations relative to the support base. A recline lever is mounted under the seat shell and is movable between a latch position and a release position. A handle on one end of the recline lever is positioned below and projects forward of the front end of the seat shell. The handle is movable upward to move the recline lever to the release position. A shroud projects forward from the front end of the seat shell and is positioned above and spaced from the handle. A top side of the shroud is positioned to act as a fixed bearing surface for grasping and moving the handle upward toward the shroud.

Abstract: A car seat has a seat structure with a seating surface and a portion configured to rest on a dedicated seat of a vehicle when installed. The seat structure has a front and a pair of opposed sides. An instruction manual is provided with the car seat. The car seat has a compartment that is configured to receive and retain the instruction manual. The compartment is disposed interior to a part of the seat structure and has an access opening that is accessible when the car seat is installed.

Abstract: An air induction system is provided for a work machine having at least one fender. The air induction system has an air inlet flow member and an air filter. The air filter is disposed within the at least one fender and accessible from outside of the work machine. The air filter is fluidly connected to and disposed downstream of the air inlet flow member. The air induction system also includes a conduit fluidly connected to and disposed downstream of the air filter.