Abstract: An injection-molded ski includes a ski body and two ski edges attached to opposite edge surfaces of the ski body. The ski body is formed from a uniform material and has top, bottom, and edge surfaces and a binding mounting platform. The binding mounting platform is formed on the top surface and receives a boot binding. The ski edges comprise an edge portion and securing features. In one embodiment, a ski is injection-molded using a molding material, such as glass-reinforced nylon or a combination of one or more suitable materials. A novel mold facilitates injection of molding material around and/or between the securing features thereby locking the edges in place when the molding material cools. Compared to conventional skis, the novel injection-molded ski has improved durability, flexibility, strength, and performance characteristics, reduced manufacturing complexity that avoids typical layup processes, and reduced susceptibility to failure due to moisture or wear.

Abstract: Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and microparticles can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.

Abstract: Described are systems, methods and arrangements for enabling fulfillment of items from printed materials. When printed material is generated it includes an embedded ordering device (“EOD”) that can be activated by a user that is viewing the printed material. Upon activation, the EOD connects to a wireless network and sends a unique identifier data to a fulfillment service. The fulfillment service, upon receiving the unique identifier data determines an item associated with the unique identifier data and a delivery destination (e.g., the address to which the printed material was delivered) and fulfills the item to the delivery destination.

Abstract: Conjugates of an active agent such as DM1 attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker, and particles comprising such conjugates have been designed. Such conjugates and particles can provide improved temporospatial delivery of the active agent, improved biodistribution and penetration in tumor, and/or decreased toxicity. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer.

Abstract: Conjugates of an active agent such as DM1 attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker, and particles comprising such conjugates have been designed. Such conjugates and particles can provide improved temporospatial delivery of the active agent, improved biodistribution and penetration in tumor, and/or decreased toxicity. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer.

Abstract: A sealing system for establishing real time sealing between two flange members is provided. The sealing system includes a seal assembly disposed between the flange members. The seal assembly includes an o-ring seal component held between an outer seal component and an inner seal component. A clamp body including a first clamp arm and a second clamp arm receive the flange members and the seal assembly positioned between the flange members. A coupling device of the sealing system is used to apply torque to clamp arms to draw them each other resulting biasing the flange member toward each other to establish sealing. Each of the clamp arms includes at least one window opening to expose a portion of outer seal component that includes an indicator configured for displaying an identification feature of the o-ring seal component of the sealing assembly.

Abstract: Conjugates of an active agent such as DM1 attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker, have been designed. Methods of administering the conjugates to a subject in need thereof are provided, for example, to treat or prevent cancer.

Abstract: Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and microparticles can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.

Abstract: A sealing system for establishing real time sealing between two flange members is provided. The sealing system includes a seal assembly disposed between the flange members. The seal assembly includes an o-ring seal component held between an outer seal component and an inner seal component. A clamp body including a first clamp arm and a second clamp arm receive the flange members and the seal assembly positioned between the flange members. A coupling device of the sealing system is used to apply torque to clamp arms to draw them each other resulting biasing the flange member toward each other to establish sealing. Each of the clamp arms includes at least one window opening to expose a portion of outer seal component that includes an indicator configured for displaying an identification feature of the o-ring seal component of the sealing assembly.

Abstract: Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and microparticles can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.

Abstract: Systems and methods for providing trust provisioning are disclosed. A utilization request requesting to utilize data stored by a secure element associated with the device may be processed by a software application. In response to processing the utilization request, a registration request message for registering the software application may be communicated to a management server. A validation code may be received from the management server in reply to the registration request message. The received validation code may be verified to match a second validation code. Subsequent to successful verification, a passcode and an identifier of the secure element may be communicated to the management server. In response to communicating the passcode and the secure element identifier, an acknowledgement may be received from the management server specifying whether registration of the software application was successful.

Abstract: The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one reacting group for reacting with a functional group on a protein.

Abstract: Described are systems, methods and arrangements for enabling fulfillment of items from printed materials. When printed material is generated it includes an embedded ordering device (“EOD”) that can be activated by a user that is viewing the printed material. Upon activation, the EOD connects to a wireless network and sends a unique identifier data to a fulfillment service. The fulfillment service, upon receiving the unique identifier data determines an item associated with the unique identifier data and a delivery destination (e.g., the address to which the printed material was delivered) and fulfills the item to the delivery destination.

Abstract: Conjugates of an active agent such as DM1 attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker, and particles comprising such conjugates have been designed. Such conjugates and particles can provide improved temporospatial delivery of the active agent, improved biodistribution and penetration in tumor, and/or decreased toxicity. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer.

Abstract: The present invention relates to the use of in vivo contrast agents in medical imaging in order to diagnose and treat disease, and to monitor and assess disease progression following treatment with a nanoparticle therapeutic agent comprising an active pharmaceutical agent. The present invention also relates to modulating nanoparticle tumor concentration by modulating the PEG density of the nanoparticles.

Abstract: The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one reacting group for reacting with a functional group on a protein.

Abstract: Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as a therapeutic, prophylactic, or diagnostic agent attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and microparticles can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided, for example, to treat or prevent cancer or infectious diseases.

Abstract: Nanoparticles and microparticles, and pharmaceutical formulations thereof, containing conjugates of an active agent such as maytansinoid attached to a targeting moiety, such as a somatostatin receptor binding moiety, via a linker have been designed. Such nanoparticles and microparticles can provide improved temporospatial delivery of the active agent and/or improved biodistribution. Methods of making the conjugates, the particles, and the formulations thereof are provided. Methods of administering the formulations to a subject in need thereof are provided.

Abstract: The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one carboxylate or carbamate ligand.

Abstract: The present teachings relate to compounds and compositions for treatment of cancers. In some embodiments, the composition comprises a platinum (IV) complex having at least one carboxylate or carbamate ligand.