Patents by Inventor Patrick Lupardus

Patrick Lupardus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IL12RB1-BINDING MOLECULES AND METHODS OF USE
    Publication number: 20240166754
    Abstract: The present disclosure relates to biologically active molecules comprising a single comain antibody (sdAb) that specifically binds to the extracellular domain of human IL12RM, compositions comprising such antibodies, and methods of use thereof.
    Type: Application
    Filed: November 20, 2023
    Publication date: May 23, 2024
    Inventors: Robert Kastelein, Deepti Rokkam, Patrick Lupardus, Sandro Vivona
  • HETERODIMERIC FC CYTOKINES AND USES THEREOF
    Publication number: 20240132562
    Abstract: The present disclosure provides IL12 and IL23 muteins as partial agonists comprising modified human p40 molecules that associate with human p35 (hP35) and human P19 (hP19) to form modified hIL-12 and IL23 partial agonists wherein the individual components of IL12 and IL23 muteins are linked to engineered Fc domains.
    Type: Application
    Filed: November 21, 2023
    Publication date: April 25, 2024
    Inventors: Patrick Lupardus, Deepti Rokkam
  • ANTI-TIGIT ANTIBODIES AND METHODS OF USE
    Publication number: 20240117037
    Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.
    Type: Application
    Filed: June 30, 2023
    Publication date: April 11, 2024
    Inventors: Jane L. GROGAN, Robert J. JOHNSTON, Yan WU, Wei-Ching LIANG, Patrick LUPARDUS, Mahesh YADAV, Dhaya SESHASAYEE, Meredith HAZEN
  • Compositions and methods related to IL27 receptor binding
    Patent number: 11873349
    Abstract: Provided herein are IL27R binding proteins that bind to IL27R? and gp130 and comprise an anti-IL27R? VHH antibody and an anti-gp130 VHH antibody.
    Type: Grant
    Filed: February 3, 2023
    Date of Patent: January 16, 2024
    Assignee: Synthekine, Inc.
    Inventors: Robert Kastelein, Patrick Lupardus, Deepti Rokkam
  • COMPOSITIONS AND METHODS RELATED TO IL27 RECEPTOR BINDING
    Publication number: 20240002542
    Abstract: Provided herein are IL27R binding proteins that bind to IL27R? and gp130 and comprise an anti-IL27R? VHH antibody and an anti-gp130 VHH antibody.
    Type: Application
    Filed: February 3, 2023
    Publication date: January 4, 2024
    Inventors: Robert Kastelein, Patrick Lupardus, Deepti Rokkam
  • ANTI-TIGIT ANTIBODIES AND METHODS OF USE
    Publication number: 20230279102
    Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.
    Type: Application
    Filed: December 7, 2022
    Publication date: September 7, 2023
    Inventors: Jane L. GROGAN, Robert J. JOHNSTON, Yan WU, Wei-Ching LIANG, Patrick LUPARDUS, Mahesh YADAV, Dhaya SESHASAYEE, Meredith HAZEN
  • ANTI-TIGIT ANTIBODIES AND METHODS OF USE
    Publication number: 20220064286
    Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.
    Type: Application
    Filed: November 15, 2021
    Publication date: March 3, 2022
    Inventors: Jane L. GROGAN, Robert J. JOHNSTON, Yan WU, Wei-Ching LIANG, Patrick LUPARDUS, Mahesh YADAV, Dhaya SESHASAYEE, Meredith HAZEN
  • ANTI-TIGIT ANTIBODIES AND METHODS OF USE
    Publication number: 20210253693
    Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.
    Type: Application
    Filed: April 29, 2021
    Publication date: August 19, 2021
    Inventors: Jane L. GROGAN, Robert J. JOHNSTON, Yan WU, Wei-Ching LIANG, Patrick LUPARDUS, Mahesh YADAV, Dhaya SESHASAYEE, Meredith HAZEN
  • ANTI-TIGIT ANTIBODIES AND METHODS OF USE
    Publication number: 20210032328
    Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.
    Type: Application
    Filed: October 6, 2020
    Publication date: February 4, 2021
    Inventors: Jane L. GROGAN, Robert J. JOHNSTON, Yan WU, Wei-Ching LIANG, Patrick LUPARDUS, Mahesh YADAV, Dhaya SESHASAYEE, Meredith HAZEN
  • IDENTIFICATION OF IMMUNOGENIC MUTANT PEPTIDES USING GENOMIC, TRANSCRIPTOMIC AND PROTEOMIC INFORMATION
    Publication number: 20200124616
    Abstract: The present disclosure provides methods of identifying a disease-specific immunogenic peptide through a series of selection steps. Immunogenic epitopes identified by methods of the present disclosure are applicable for use in peptide-based immunotherapy, preferably cancer therapy. Furthermore, the methods of the present disclosure may be performed in a high-throughput manner and serve as a means of personalized vaccine development and therapy. Also provided are compositions of immunogenic peptides as well as methods of treatment comprising said compositions.
    Type: Application
    Filed: January 3, 2020
    Publication date: April 23, 2020
    Applicant: Genentech, Inc.
    Inventors: Lelia DELAMARRE, Patrick LUPARDUS, Ira MELLMAN, Mahesh YADAV, Suchit JHUNJHUNWALA, Jennie LILL
  • Identification of immunogenic mutant peptides using genomic, transcriptomic and proteomic information
    Patent number: 10564165
    Abstract: The present disclosure provides methods of identifying a disease-specific immunogenic peptide through a series of selection steps. Immunogenic epitopes identified by methods of the present disclosure are applicable for use in peptide-based immunotherapy, preferably cancer therapy. Furthermore, the methods of the present disclosure may be performed in a high-throughput manner and serve as a means of personalized vaccine development and therapy. Also provided are compositions of immunogenic peptides as well as methods of treatment comprising said compositions.
    Type: Grant
    Filed: September 10, 2015
    Date of Patent: February 18, 2020
    Assignee: GENENTECH, INC.
    Inventors: Lelia Delamarre, Patrick Lupardus, Ira Mellman, Mahesh Yadav, Suchit Jhunjhunwala, Jennie Lill
  • ANTI-TIGIT ANTIBODIES AND METHODS OF USE
    Publication number: 20190119376
    Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.
    Type: Application
    Filed: May 31, 2018
    Publication date: April 25, 2019
    Inventors: Jane L. GROGAN, Robert J. JOHNSTON, Yan WU, Wei-Ching LIANG, Patrick LUPARDUS, Mahesh YADAV, Dhaya SESHASAYEE, Meredith HAZEN
  • ANTI-HEMAGGLUTININ ANTIBODIES AND METHODS OF USE
    Publication number: 20190023770
    Abstract: The present invention provides anti-hemagglutinin antibodies, compositions comprising anti-hemagglutinin antibodies, and methods of using the same.
    Type: Application
    Filed: January 18, 2018
    Publication date: January 24, 2019
    Applicant: Genentech, Inc.
    Inventors: Min Xu, Mercedesz Balazs, Ning Chai, Nancy Y. Chiang, Henry Chiu, Zhaoyu Jin, Zhonghua Lin, Patrick Lupardus, Gerald Nakamura, Hyunjoo Park, Lee Swem
  • Anti-TIGIT antibodies and methods of use
    Patent number: 10047158
    Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: August 14, 2018
    Assignee: Genentech, Inc.
    Inventors: Jane L. Grogan, Robert J. Johnston, Yan Wu, Wei-Ching Liang, Patrick Lupardus, Mahesh Yadav, Dhaya Seshasayee, Meredith Hazen
  • Anti-tigit antibodies and methods of use
    Patent number: 10017572
    Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.
    Type: Grant
    Filed: September 23, 2016
    Date of Patent: July 10, 2018
    Assignee: Genentech, Inc.
    Inventors: Jane L. Grogan, Robert J. Johnston, Yan Wu, Wei-Ching Liang, Patrick Lupardus, Mahesh Yadav, Dhaya Seshasayee, Meredith Hazen
  • ANTI-TIGIT ANTIBODIES AND METHODS OF USE
    Publication number: 20180186875
    Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.
    Type: Application
    Filed: February 13, 2018
    Publication date: July 5, 2018
    Inventors: Jane L. GROGAN, Robert J. JOHNSTON, Yan WU, Wei-Ching LIANG, Patrick LUPARDUS, Mahesh YADAV, Dhaya SESHASAYEE, Meredith HAZEN
  • Anti-hemagglutinin antibodies and methods of use
    Patent number: 9908931
    Abstract: The present invention provides anti-hemagglutinin antibodies, compositions comprising anti-hemagglutinin antibodies, and methods of using the same.
    Type: Grant
    Filed: February 12, 2016
    Date of Patent: March 6, 2018
    Assignee: GENENTECH, INC.
    Inventors: Min Xu, Mercedesz Balazs, Ning Chai, Nancy Chiang, Henry Chiu, Zhaoyu Jin, Zhonghua Lin, Patrick Lupardus, Gerald r. Nakamura, Hyunjoo Park, Lee Swem
  • ANTI-TIGIT ANTIBODIES AND METHODS OF USE
    Publication number: 20170088613
    Abstract: The invention provides anti-TIGIT (T-cell immunoreceptor with Ig and ITIM domains) antibodies and methods of using the same.
    Type: Application
    Filed: September 23, 2016
    Publication date: March 30, 2017
    Inventors: Jane L. GROGAN, Robert J. JOHNSTON, Yan WU, Wei-Ching LIANG, Patrick LUPARDUS, Mahesh YADAV, Dhaya SESHASAYEE, Meredith HAZEN
  • Anti-hemagglutinin antibodies and methods of use
    Patent number: 9598481
    Abstract: The present invention provides anti-hemagglutinin antibodies, compositions comprising anti-hemagglutinin antibodies, and methods of using the same.
    Type: Grant
    Filed: May 29, 2015
    Date of Patent: March 21, 2017
    Assignee: Genetech, Inc.
    Inventors: Min Xu, Mercedesz Balazs, Ning Chai, Nancy Chiang, Henry Chiu, Zhonghua Lin, Patrick Lupardus, Gerald R. Nakamura, Hyunjoo Park, Lee Swem
  • ANTI-HEMAGGLUTININ ANTIBODIES AND METHODS OF USE
    Publication number: 20160168230
    Abstract: The present invention provides anti-hemagglutinin antibodies, compositions comprising anti-hemagglutinin antibodies, and methods of using the same.
    Type: Application
    Filed: February 12, 2016
    Publication date: June 16, 2016
    Applicant: Genentech, Inc.
    Inventors: Min XU, Mercedesz BALAZS, Ning CHA, Nancy CHIANG, Henry CHIU, Zhaoyu JIN, Zhonghua LIN, Patrick LUPARDUS, Gerald R. NAKAMURA, Hyunjoo PARK, Lee SWEM