Abstract: The present invention provides optimized nucleic acid molecules, methods for optimization of nucleic acid molecules and uses of optimized nucleic acid molecules. A modular design principle is provided that is suitable to generate a nucleic acid, particularly mRNA, which is tailored for a respective application. The nucleic acid molecules of the present invention can be obtained by the versatile combination of multiple modules on nucleic acid level. Such nucleic acid, e.g. mRNA, can be tailored by combining one or more modules, comprising (i) a nucleic acid moiety encoding a polypeptide of interest (e.g. a protein potentially producing a therapeutic outcome) and (ii) at least one further coding or non-coding nucleic acid moiety, e.g.

Abstract: A turbine engine wall having a cold side and a hot side and including a plurality of cooling orifices for enabling air flowing on the cold side of the wall to penetrate to the hot side at least some of the cooling orifices being plugged by a plugging material so as to define a minimum level of porosity for the wall corresponding to putting the turbine engine into service, and the plugged cooling orifices being suitable for being unplugged progressively throughout the lifetime of the turbine engine in order to define a maximum level of porosity for the wall corresponding to an end of lifetime for the turbine engine, the plugging being performed by alternating at least one of the following rows or lines: circumferential rows, axial rows, diagonal lines, so as to lie in the range one-third to one-half of the maximum porosity.

Abstract: A turbine engine wall having a cold side and a hot side and including a plurality of cooling orifices for enabling air flowing on the cold side of the wall to penetrate to the hot side at least some of the cooling orifices being plugged by a plugging material so as to define a minimum level of porosity for the wall corresponding to putting the turbine engine into service, and the plugged cooling orifices being suitable for being unplugged progressively throughout the lifetime of the turbine engine in order to define a maximum level of porosity for the wall corresponding to an end of lifetime for the turbine engine, the plugging being performed by alternating at least one of the following rows or lines: circumferential rows, axial rows, diagonal lines, so as to lie in the range one-third to one-half of the maximum porosity.

Abstract: An annular wall for a turbomachine combustion chamber is disclosed, comprising cooling orifices through which cooling air can circulate through the annular wall, each having an air injection axis oriented orthogonal to a longitudinal axis of the annular wall. The cooling orifices are distributed into first annular rows of cooling orifices oriented in a first circumferential direction from an outer face as far as an inner face of the annular wall, and second annular rows of cooling orifices oriented in a second circumferential direction opposite the first circumferential direction from the outer face as far as the inner face of said annular wall. The first annular rows and the second annular rows of cooling orifices are arranged alternately along the longitudinal axis.

Abstract: A personal care product, a household product, an industrial formulation, or a medicinal product of at least a fluorosurfactant and/or a natural or naturally-derived or synthetic, and/or *Eco-friendly (See Description) materials such as PEG-4 rapeseedamide, glycerth 2-cocate, Behenamidopropyl dimethylamine, and lactic acid (and derivatives of) as components and at least a second component (which may or may not be present in the formulation in question already) selected from the group consisting of citric acid, glyconic acid, gluconic acid, sodium erythorbate, iodo propynyl butyl carbamate, antioxidants, dehydroacetic acid, parabens, DMDM hydantoin, diazolidinyl urea, caprylyl glycol, glucono ? lactone, EDTA, amine oxides (other than fluorosurfactants having amine oxide groups, which are included as component 1 materials), glutaraldehydes, chlorhexidine, phenoxyethanol, benzyl alcohol, salicylic acid, dipropylene glycol, quaternary ammonium (benzalkonium and benzethonium chlorides), glycereth-2-cocoate, PEG-4 R

Abstract: The present invention relates to color stable personal care compositions that provide anti-oxidiation, moisturization, and/or prevent biodegradation in personal care formulations. These compositions contain erythorbic acid or a salt thereof, caffeic acid or a salt thereof, ?-gluconolactone, or a mixture thereof. The present invention further relates to methods of moisturizing skin with erythorbic acid or a salt thereof, or ?-gluconolactone. The present invention also relates to concentrates of active ingredients preloaded with a sufficient amount of an anti-oxidation, moisturizing and/or biodegradation prevention agent so that when it is diluted for use, the final formulation includes an anti-oxidation, moisturizing and/or biodegradation prevention effective amount of the anti-oxidation, moisturizing, and/or biodegradation prevention agent.

Abstract: The present invention provides a method for controlling allergens by applying an anti-allergenic effective amount of one or more anti-allergenic agents selected from hyperbranched polymers, amines (including tertiary amines), hops extracts, anti-allergenic iodo derivatives, quaternary ammonium compounds, hydantoins and hydantoin blends, polyhexamethylenebiguanidine hydrochloride, natural oils, anti-allergenic natural acids, sodium carbonate, chelating agents, cyclic ketone acids (e.g., dehydroacetic acid (DHA) and salts thereof (including sodium dehydroacetate and the monohydrate thereof)), anti-allergenic surfactants, organic phosphates, hydrogen peroxide, butylene glycol, phenoxyethanol, sodium salicylate, and mixtures thereof, to the allergens or a substrate on which they are located. These anti-allergenic agents are particularly effective at controlling household allergens, such as dust mites.