Patents by Inventor Patrick M. Guertin
Patrick M. Guertin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11274274Abstract: The invention discloses a bioreactor apparatus (1;101;201;301) for cultivation of cells comprising: a) a disposable bioreactor vessel (2) with one or more walls (3,4,5) defining an inner volume (6), at least one port (10) in a wall, wherein the disposable bioreactor vessel is positioned in a rigid support structure (8;108); and b) a heater (9;109;209;309), capable of heating an amount of culture medium to a target temperature in the range of 55-95° C., while the amount of culture medium is being confined in or conveyed to the inner volume.Type: GrantFiled: April 12, 2016Date of Patent: March 15, 2022Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Colin R. Tuohey, Richard Lee Damren, Thomas John Erdenberger, Parish M. Galliher, Patrick M. Guertin
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Publication number: 20180119084Abstract: The invention discloses a bioreactor apparatus (1;101;201;301) for cultivation of cells comprising: a) a disposable bioreactor vessel (2) with one or more walls (3,4,5) defining an inner volume (6), at least one port (10) in a wall, wherein the disposable bioreactor vessel is positioned in a rigid support structure (8;108); and b) a heater (9;109;209;309), capable of heating an amount of culture medium to a target temperature in the range of 55-95° C., while the amount of culture medium is being confined in or conveyed to the inner volume.Type: ApplicationFiled: April 12, 2016Publication date: May 3, 2018Inventors: Colin R. Tuohey, Richard Lee Damren, Thomas John Erdenberger, Parish M. Galliher, Patrick M. Guertin
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Patent number: 9932562Abstract: The invention provides a method of increasing product yield per culture in a population of product-secreting cells bound to a scaffold, for example, a microcarrier, at least partially immersed in a culture medium in a bioreactor. The method comprising: semi-harvesting product by removing a volume of the culture medium with a first-secreted product concentration while leaving the scaffold with the bound cells in the bioreactor; re-feeding the cells by adding a fresh culture medium to increase the culture medium in the bioreactor to approximately the original volume; agitating the culture medium to allow the cells to grow and release a second-secreted product concentration; harvesting product by removing the culture medium with the second-secreted product concentration while leaving the scaffold with the bound cells behind. Also disclosed is a method of increasing virus yield per culture in a population of virus-infected cells bound to a microcarrier suspended in a culture medium.Type: GrantFiled: October 15, 2013Date of Patent: April 3, 2018Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: Patrick M. Guertin, Joseph D. Crowell
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Patent number: 9655960Abstract: The invention provides a an inactive, non-replicating vaccine comprising whole virion, chemically inactivated Yellow Fever virus which is inactivated using a method that ensures preservation of critical, neutralizing epitopes. The Yellow Fever virus has been adapted to propagate in cells to higher yields than the unadapted virus. The invention also provides methods for preventing Yellow Fever viral infection.Type: GrantFiled: May 2, 2014Date of Patent: May 23, 2017Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: Cynthia K. Lee, Thomas P. Monath, Patrick M. Guertin, Edward G. Hayman
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Patent number: 9499781Abstract: Disclosed herein is a system and method for condensing moisture in a moist gas stream entering a bioreactor or leaving a bioreactor, forming a dry gas stream for entering or leaving the bioreactor.Type: GrantFiled: March 29, 2012Date of Patent: November 22, 2016Assignee: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: Richard Damren, Colin Touhey, Thomas Erdenberger, Michael Fisher, Geoffrey L. Hodge, Patrick M. Guertin, Parrish M. Galliher
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Patent number: 9127242Abstract: A single-use, single or multiple tissue, organ, and graft bioreactor and environmental control system is designed to replicate the necessary conditions for growth of tissues, organs, or grafts, while addressing problems in scaling up the tissue growth; adaptation to a single-use or disposable format; and operation as a stand-alone unit that provides full environmental control of cell culture conditions.Type: GrantFiled: April 5, 2010Date of Patent: September 8, 2015Inventors: Patrick M. Guertin, Parrish M. Galliher, Michael Fisher, Joseph D. Crowell, Colin R. Tuohey, Laura A. Niklason, William E. Tente, Shannon M. Dahl, Juliana Blum, Justin Strader
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Publication number: 20140322270Abstract: The invention provides a an inactive, non-replicating vaccine comprising whole virion, chemically inactivated Yellow Fever virus which is inactivated using a method that ensures preservation of critical, neutralizing epitopes. The Yellow Fever virus has been adapted to propagate in cells to higher yields than the unadapted virus. The invention also provides methods for preventing Yellow Fever viral infection.Type: ApplicationFiled: May 2, 2014Publication date: October 30, 2014Applicant: GE HEALTHCARE BIO-SCIENCES CORP.Inventors: CYNTHIA K. LEE, THOMAS P. MONATH, PATRICK M. GUERTIN, EDWARD G. HAYMAN
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Patent number: 8741312Abstract: The invention provides a an inactive, non-replicating vaccine comprising whole virion, chemically inactivated Yellow Fever virus which is inactivated using a method that ensures preservation of critical, neutralizing epitopes. The Yellow Fever virus has been adapted to propagate in cells to higher yields than the unadapted virus. The invention also provides methods for preventing Yellow Fever viral infection.Type: GrantFiled: January 25, 2011Date of Patent: June 3, 2014Assignee: GE Healthcare Bio-Sciences Corp.Inventors: Cynthia K. Lee, Thomas P. Monath, Patrick M. Guertin, Edward G. Hayman
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Publication number: 20140106403Abstract: The invention provides a method of increasing product yield per culture in a population of product-secreting cells bound to a scaffold, for example, a microcarrier, at least partially immersed in a culture medium in a bioreactor. The method comprising: semi-harvesting product by removing a volume of the culture medium with a first-secreted product concentration while leaving the scaffold with the bound cells in the bioreactor; re-feeding the cells by adding a fresh culture medium to increase the culture medium in the bioreactor to approximately the original volume; agitating the culture medium to allow the cells to grow and release a second-secreted product concentration; harvesting product by removing the culture medium with the second-secreted product concentration while leaving the scaffold with the bound cells behind. Also disclosed is a method of increasing virus yield per culture in a population of virus-infected cells bound to a microcarrier suspended in a culture medium.Type: ApplicationFiled: October 15, 2013Publication date: April 17, 2014Applicant: XCELLEREX, INC.Inventors: PATRICK M. GUERTIN, JOSEPH D. CROWELL
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Publication number: 20120260671Abstract: Disclosed herein is a system and method for condensing moisture in a moist gas stream entering a bioreactor or leaving a bioretractor, forming a dry gas stream for entering or leaving the bioreactor.Type: ApplicationFiled: March 29, 2012Publication date: October 18, 2012Applicant: Xcellerex, Inc.Inventors: Richard L. DAMREN, Colin Tuohey, Thomas Erdenberger, Michael Fisher, Geoffrey L. Hodge, Patrick M. Guertin, Parrish M. Galliher
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Publication number: 20120190068Abstract: Disclosed is a method of increasing product yield per culture in a population of bound product-secreting cells in a bioreactor, the method comprising: semi-harvesting product by removing a volume of the culture medium with a first-secreted product concentration; re-feeding the bound population of product-secreting cells by adding an amount of a fresh culture medium sufficient to increase the volume of the culture medium to approximately the original volume of the culture medium; agitating the culture medium under sufficient conditions and for a sufficient time period to allow the bound population of product-secreting cells to grow and to release a second-secreted product concentration into the culture medium; and harvesting product.Type: ApplicationFiled: January 20, 2012Publication date: July 26, 2012Applicant: Xcellerex, Inc.Inventors: Patrick M. GUERTIN, Joseph D. Crowell
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Publication number: 20120028234Abstract: A single-use, single or multiple tissue, organ, and graft bioreactor and environmental control system is designed to replicate the necessary conditions for growth of tissues, organs, or grafts, while addressing problems in scaling up the tissue growth; adaptation to a single-use or disposable format; and operation as a stand-alone unit that provides full environmental control of cell culture conditions.Type: ApplicationFiled: April 5, 2010Publication date: February 2, 2012Inventors: Patrick M. Guertin, Parrish M. Galliher, Michael Fisher, Joseph D. Crowell, Colin R. Tuohey, Laura A. Niklason, William E. Tente, Shannon M. Dahl, Juliana Blum, Justin Strader
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Publication number: 20110287519Abstract: The invention provides a an inactive, non-replicating vaccine comprising whole virion, chemically inactivated Yellow Fever virus which is inactivated using a method that ensures preservation of critical, neutralizing epitopes. The Yellow Fever virus has been adapted to propagate in cells to higher yields than the unadapted virus. The invention also provides methods for preventing Yellow Fever viral infection.Type: ApplicationFiled: January 25, 2011Publication date: November 24, 2011Applicant: Xcellerex, Inc.Inventors: Cynthia K. LEE, Thomas P. MONATH, Patrick M. GUERTIN, Edward G. HAYMAN
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Patent number: 5631159Abstract: Methods are provided for producing serum-free, animal cell culture media which have enhanced cell culture properties, such as cell growth, cell viability and protein production properties. The cell culture properties of standard serum-free media formulations, which include compositions such as inorganic salts, glucose, fatty acids, amino acids and vitamins, can be enhanced according to the methods of the invention, by providing the media with an additive. The additive in one embodiment can be produced by the acid or base catalyzed hydrolysis of a phosphoglyceride.Type: GrantFiled: September 22, 1993Date of Patent: May 20, 1997Assignee: Creative BioMolecules, Inc.Inventors: Paul G. Marshall, Patrick M. Guertin