Abstract: A method of signal integrity analysis includes providing a pre-defined circuit layout in SPICE format; selecting from a menu at least one of a technology, a driver, a driver package, a transmission line, a termination, a receiver package, a stimulus, a measurement, options, and sweep parameters for the predefined circuit layout; generating a SPICE netlist from the pre-defined circuit layout; simulating the predefined circuit layout from the SPICE netlist; and generating as output at least one of a listing, a waveform, and a signal measurement from the simulation of the pre-defined circuit layout.