Abstract: A fluid component includes at least one substrate of a material that can be etched and an etch stop layer for said material means for detecting the properties of a fluid and/or for activating said fluid and provided on a first side of said etch stop layer and means for receiving said fluid, formed in the substrate and provided on the second side of the etch stop layer.

Abstract: The present invention relates to a method of transporting an analyte present in a sample, to a method of concentrating an analyte present in a sample, and to a device for implementing these methods. In the method of transporting an analyte present in a sample of the present invention, a solution A in which the analyte is attached to magnetic particles is prepared from the sample; the solution A is introduced into a first container connected via a bottleneck to a second container; and the analyte attached to the magnetic particles is moved, by means of a magnetic system, from the first container to the second container via the bottleneck, the second container being filled with all or part of the solution A and/or with another solution.

Abstract: The disclosure relates to a biological analysis device including: means for circulating a fluid to be analyzed, comprising a fluidic chamber, optical detection means based on a semiconductor, including a detection front face, a rear face and pads of electrical contacts located on this rear face.

Abstract: The method for controlling the progression of a fluid, from upstream to downstream, in a microfluidic component comprising for example a plurality of microchannels each comprising a plurality of successive reaction or detection zones and a plurality of passive valves, controls the progression of the fluid in the microchannels by controlling the increase of a pressure difference between upstream and downstream of the component. The method controls the pressure difference increase discontinuously in the form of enabling pulses so as in particular to synchronize passing of the corresponding passive valves of the microchannels. The pressure difference is advantageously adjusted to a zero value between two successive enabling pulses.

Abstract: The present invention relates especially to a process for the localized distribution of drops of a liquid of interest on an active surface. The process comprises the following steps an introduction of liquid of interest into a box containing the said active surface, and an extraction of liquid of interest from the said box, the said active surface and also the other surfaces inside the box being substantially non-wetting with respect to the liquid of interest, with the exception of several uptake areas localized on the said active surface, which are each suitable for taking up a drop of liquid of interest. The uptake areas may surround working areas. The present invention also relates to processes for the electrochemical and optical detection of at least one analyte in a liquid of interest, and to an electropolymerization process.

Abstract: The present invention relates to an operating device characterized in that it comprises an active surface that is substantially non-wetting with respect to a liquid of interest; at least one zone for the localized capture of a drop of said liquid formed on said active surface; at least one operating zone arranged with a capture zone in such a way that the operating zone is at least partially covered by the drop of the liquid when said drop is captured by said capture zone; and means for leaving a drop of said liquid on said capture zone. This device makes it possible in particular to form high-density arrays of drops of said liquid on a surface, with the aim in particular of carrying out chemical and/or biochemical reactions and/or of analysing the liquid of interest in each drop. It finds, for example, an application in biological chips.

Abstract: A method for dividing an analyte present in a solution and that is fixed on magnetic particles, and devices to be used in the method and systems for implementing the method. The method includes sedimentation of the magnetic particles together with separation into a plurality of residues. One implementation: forms at least a residue of magnetic particles in a first receptacle; and displaces the at least the residues towards a plurality of second receptacles, preferably by relative translation of a magnetic system. The second receptacle is connected to the first receptacle through a fluid channel.

Abstract: The present invention relates to a work device (1) comprising work zones. It can be used to obtain a matrix of drops on a surface, using a liquid of interest (E). It comprises a work box (Bo) provided with means (o, s) for introducing and extracting the liquid respectively into and from the box; a substrate (S) comprising an active surface that is substantially non-wetting for said liquid of interest contained in said box; distinct work zones (Zt) formed on said active surface and each surrounded by a border (b) formed on said active surface, the borders not touching one another and having no common edge and having a geometry such that when the liquid of interest is extracted from the box, a drop (g) of the liquid of interest remains imprisoned by each border and in contact with the work zone that it surrounds.

Abstract: A biochip, and a device for reading the biochip, the biochip including a plurality of molecular recognition areas distributed with a determined layout to create a format of molecular recognition areas and a mechanism for making optical position marks for each molecular recognition area, distributed with a determined layout to form an optical format. The optical format and the format of recognition areas are formats produced independently of each other. A mechanism is provided determining the relative position of the two formats being provided on the biochip.

Abstract: Gluing process for micro-structured substrates. The invention is applicable particularly to the fabrication of micro-fluidic components. In order to glue a micro-structured substrate (2) having upper coplanar plane areas (6) and recesses between them, a grid (10) is placed above the substrate, the grid is coated with a glue (12), using a tool (16) that presses on the grid and locally brings it into contact with the areas, so as to deposit a film (20) of glue droplets on them, and the grid is removed. Furthermore, the upper coplanar plane areas (6) are treated before the film of glue droplets is deposited, this treatment being designed to adapt wettability of these areas to the glue.

Abstract: The invention concerns a standard micro-component (4) for calibrating or standardizing fluorescence measuring instruments, comprising a substrate (1) whereon is arranged at least one thin film (2). The thin film (2) includes fluorescent components. At least one first zone (3) of null thickness is formed in the thin film (2), thereby exposing the substrate (1). The thin film (2) comprises at least one exposed zone (2a), such that first and second fluorescence levels are respectively defined in the non exposed part and in the exposed part (2a) of the thin film (2). The second fluorescence level is lower than the first fluorescence level. The standard micro-component (4) can also include a plurality of stacked thin films so as to define a plurality of fluorescence levels.

Abstract: The invention concerns a device (1) for testing at least one sample by optical detection of luminescence, comprising a site for receiving (3) the sample, said site being arranged in such a way that the sample can receive a luminescence excitation and emit a luminescence light in an optical guiding plane (2) of the device, the device further comprising collection means (7) optically connected to the optical guiding plane (2) to receive the luminescence light. The device further comprises means that make it possible to send back towards the collection means (4) a part of the luminescence light emitted in the optical guiding plane and not directly collected by the collection means.

Abstract: The invention relates to hydraulic device produced from one or several components, for example from a support comprising: an operative cavity, at least two ducts, for example an inlet and outlet for a liquid of interest which communicate with said operative cavity, at least two valve bodies with no moving pieces for control of said cavity. The above is characterised in that said device further comprises two trapping chambers for a gas, for example, air, in communication only and respectively with two ducts, by means of two connecting channels respectively, both pertaining to thermal exchange with a heat source.

Abstract: A device and process for the amplification of fluorescence emitted by an areal sample. The device includes a support transmitting all or part of a fluorescence signal and configured to support the areal sample and a thin layer interposed between the support and the areal sample. The thin layer has a refractive index greater than the refractive index of the support and than the refractive index of a medium flooding the areal sample during a fluorescence measurement. The thickness of the thin layer is chosen so that the thin layer transmits all or part of the fluorescence signal which is measured after passing through the support.

Abstract: Optical switch comprising optical means (120) and driving means (114, 115, 124) on a substrate (100), cooperating with optical means to make them pivot between a rest position and at least one active position. According to the invention, the switch comprises first mobile stop means (122), rigidly fixed to the optical means (120, 130) so that they can pivot with the optical means, and second fixed stop means (128) arranged in a plane approximately parallel to the main face (110) of the substrate and cooperating with the first stop means, to fix the said active position of the optical means. Application to make an optical cross connect.

Abstract: This invention relates to a microfluidic device for the manipulation of a non-magnetic liquid, comprising at least one cell comprising:

Abstract: This invention relates to a substrate (1) with a reception surface (4) for a layer of material to be insolated by insolation light, wherein means forming a mirror (3) are arranged between said reception surface (4) and the layer of material to be insolated, these means forming a mirror (3) operating for the wavelength of the insolation light. This type of substrate may be used for making microelectronic or microtechnological devices, or biochips.

Abstract: The present invention relates to a method of transporting an analyte present in a sample, to a method of concentrating an analyte present in a sample, and to a device for implementing these methods.

Abstract: Optical switch comprising optical means (120) and driving means (114, 115, 124) on a substrate (100), cooperating with optical means to make them pivot between a rest position and at least one active position. According to the invention, the switch comprises first mobile stop means (122), rigidly fixed to the optical means (120, 130) so that they can pivot with the optical means, and second fixed stop means (128) arranged in a plane approximately parallel to the main face (110) of the substrate and cooperating with the first stop means, to fix the said active position of the optical means.

Abstract: The invention relates to the amplification of the fluorescence emitted by an areal sample. The device (10) includes a support (11) transmitting all or part of the fluorescence signal and intended to support the areal sample (13), a thin layer (12) being interposed between the support (11) and the areal sample (13), the thin layer having a refractive index greater than the refractive index of the support and than the refractive index of the medium flooding the areal sample during a fluorescence measurement, the thickness of the thin layer being chosen so that the thin layer (12) transmits all or part of the fluorescence signal which is measured after passing through the support (12).