Patents by Inventor Patrick R Maloney

Patrick R Maloney has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CXCR6 INHIBITORS AND METHODS OF USE
    Publication number: 20220402908
    Abstract: Provided herein are small molecule inhibitors of CXCR6 receptor, compositions comprising the compounds, and methods of using the compounds and compositions. The compounds are 9-azbicyclo[3.3.1]nonane or 9-diazbicyclo[3.3.1]nonane derivatives, whose synthesis is also described. Also provided are method of treating a disease or condition (such as, cancer) mediated by CXCR6/CXCL16 signaling pathway in a mammal.
    Type: Application
    Filed: July 7, 2020
    Publication date: December 22, 2022
    Inventors: Satyamaheshwar PEDDIBHOTLA, Paul M. HERSHBERGER, Richard Jason KIRBY, Siobhan MALANY, Layton H. SMITH, Patrick R. MALONEY, Hampton SESSIONS, Daniela DIVLIANSKA, Anthony B. PINKERTON
  • Small molecule agonists of neurotensin receptor 1
    Patent number: 11261164
    Abstract: Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
    Type: Grant
    Filed: January 14, 2020
    Date of Patent: March 1, 2022
    Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    Inventors: Anthony B. Pinkerton, Paul M. Hershberger, Satyamaheshwar Peddibhotla, Patrick R. Maloney, Michael P. Hedrick
  • SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1
    Publication number: 20200354324
    Abstract: Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
    Type: Application
    Filed: January 14, 2020
    Publication date: November 12, 2020
    Inventors: Anthony B. PINKERTON, Paul M. HERSHBERGER, Satyamaheshwar PEDDIBHOTLA, Patrick R. MALONEY, Michael P. HEDRICK
  • Small molecule agonists of neurotensin receptor 1
    Patent number: 10584103
    Abstract: Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: March 10, 2020
    Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    Inventors: Anthony B. Pinkerton, Paul M. Hershberger, Satyamaheshwar Peddibhotla, Patrick R. Maloney, Michael P. Hedrick
  • SMALL MOLECULE AGONISTS OF NEUROTENSIN RECEPTOR 1
    Publication number: 20190023665
    Abstract: Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
    Type: Application
    Filed: September 24, 2018
    Publication date: January 24, 2019
    Inventors: Anthony B. PINKERTON, Paul M. HERSHBERGER, Satyamaheshwar PEDDIBHOTLA, Patrick R. MALONEY, Michael P. HEDRICK
  • Small molecule agonists of neurotensin receptor 1
    Patent number: 10118902
    Abstract: Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
    Type: Grant
    Filed: June 24, 2015
    Date of Patent: November 6, 2018
    Assignee: SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE
    Inventors: Anthony B. Pinkerton, Paul M. Hershberger, Satyamaheshwar Peddibhotla, Patrick R. Maloney, Michael P. Hedrick
  • Small Molecule Agonists of Neurotensin Receptor 1
    Publication number: 20170240514
    Abstract: Provided herein are small molecule neurotensin receptor agonists, compositions comprising the compounds, and methods of using the compounds and compositions comprising the compounds.
    Type: Application
    Filed: June 24, 2015
    Publication date: August 24, 2017
    Inventors: Anthony B. PINKERTON, Paul M. HERSHBERGER, Satyamaheshwar PEDDIBHOTLA, Patrick R. MALONEY, Michael P. HEDRICK
  • Farnesoid X receptor agonists
    Patent number: 7319109
    Abstract: The invention relates to a compound of formula (I): wherein all variables are as defined herein and to pharmaceutical compositions, methods of using, and processes for preparing the same.
    Type: Grant
    Filed: November 12, 2003
    Date of Patent: January 15, 2008
    Assignee: Smith Kline Beecham Corporation
    Inventors: Sharon D Boggs, Jon L Collins, Stephen M Hyatt, Patrick R Maloney
  • Inhibitors of 5-.alpha.-testosterone reductase
    Patent number: 5543406
    Abstract: The present invention relates to certain substituted 17.beta.-substituted carbonyl-6-azaandrost-4-en-3-ones of formula (I), especially those of formula (IG) ##STR1## wherein R.sup.1 and R.sup.2 arei) independently hydrogen or lower alkyl and the bond between the carbons bearing R.sup.1 and R.sup.2 is a single or a double bond, orii) taken together are a --CH.sub.2 -- group to form a cyclopropane ring, and the bond between the carbons bearing R.sup.1 and R.sup.2 is a single bond;R.sup.3c is hydrogen;R.sup.4c is hydrogen, lower alkyl, lower cycloalkyl, lower alkenyl, alkanoyl of 2-6 carbons, --(CH.sub.2).sub.m CO.sub.2 R.sup.16, --(CH.sub.2).sub.m Ar.sup.a, --(CH.sub.2).sub.n 'CONR.sup.17 R.sup.18, --(CH.sub.2).sub.n 'NR.sup.17 R.sup.18 or --(CH.sub.2).sub.n 'OR.sup.16, wherein R.sup.16 is hydrogen, lower alkyl or lower alkenyl; R.sup.17 and R.sup.18 are independently hydrogen, lower alkyl lower cycloalkyl or lower alkenyl; Ar.sup.
    Type: Grant
    Filed: August 15, 1994
    Date of Patent: August 6, 1996
    Assignee: Glaxo Wellcome, Inc.
    Inventors: Robert C. Andrews, Cynthia M. Cribbs, Stephen V. Frye, Curt D. Haffner, Patrick R. Maloney