Abstract: Embodiments are directed to sharing namespaces across file system clusters. A file in a spoke file system may be determined based on a command provided to the spoke file system such that the file may be associated with an inode mask. Data blocks associated with the file may be determined based on the command and the inode mask such that the data blocks may be absent from the spoke file system. Requests for leases may be generated based on the absent data blocks such that each lease request corresponds to a portion of the absent data blocks Employing the leases provided by a hub file system to: copy the absent data blocks from the hub file system where each portion of absent data blocks may be associated with a lease; updating the inode mask to include the leases and each copied portion of absent blocks.

Abstract: This invention is directed to the treatment of cancers, e.g., inflammatory breast cancer, with NK (natural killer) cells wherein the cells are modified ex vivo such that their ability to overcome the chemorepellant effect of a tumor is enhanced. The cells may be genetically modified ex vivo and/or modified by contacting the cells ex vivo with an anti-chemorepellant agent. This invention also provides ex vivo modified NK cells, which are modified such that they express no or substantially no CXCR4 on their cell surface, or express CXCR7, or express a chimeric antigen receptor, or combinations thereof. The invention also relates to methods for treating a patient having a tumor, e.g., inflammatory breast cancer, by administering the modified NK cells, with or without treatment with other conventional anticancer treatments, e.g., chemotherapy, radiotherapy, viral therapies, hormonal therapies, as well as other immunotherapies and anti-chemorepellant therapies.

Abstract: The invention described herein relates to methods and compositions for treating cancer in a patient or a tumor cell by administering an effective amount of an anti-fugetactic agent and an additional anti-cancer agent.

Abstract: The invention described herein relates to methods and compositions for treating cancer in a patient or a tumor cell by administering an effective amount of an anti-fugetactic agent and an additional anti-cancer agent.

Abstract: The invention described herein relates to methods and compositions for treating cancer in a patient or a tumor cell by administering an effective amount of an anti-fugetactic agent and an additional anti-cancer agent.

Abstract: The present invention relates to methods and compositions for treating cancer and enhancing the immune response against cancer cells using the combination of an inhibitor of CXCL12 signaling and an immune checkpoint inhibitor. The invention further relates to compositions and kits of parts comprising an inhibitor of CXCL 12 signaling and an immune checkpoint inhibitor for use in the methods of the invention.

Abstract: The invention provides a detachable wind guard for a flute-type instrument comprising an elongate, arcuate cover configured to wrap over a flute barrel. The cover has a center section with a radius larger than the radius of the flute barrel and includes a tapered, recessed facing edge configured to leave an embouchure hole uncovered. A domed apex of the center section is sized to accommodate a microphone, and a microphone clip is coupled inside the domed apex. End sections taper to a radius sized to conform to the flute barrel. An elongate, arcuate holder positioned opposite the cover has a radius sized to conform to the flute barrel. A connector pin passes through knuckles on both the cover and holder to form a hinge that allows the wind guard to open in a clamshell manner. Torsion springs around the connector pin bias the holder in a closed position.

Abstract: This invention is directed to the treatment of cancers, e.g., inflammatory breast cancer, with NK (natural killer) cells wherein the cells are modified ex vivo such that their ability to overcome the chemorepellant effect of a tumor is enhanced. The cells may be genetically modified ex vivo and/or modified by contacting the cells ex vivo with an anti-chemorepellant agent. This invention also provides ex vivo modified NK cells, which are modified such that they express no or substantially no CXCR4 on their cell surface, or express CXCR7, or express a chimeric antigen receptor, or combinations thereof. The invention also relates to methods for treating a patient having a tumor, e.g., inflammatory breast cancer, by administering the modified NK cells, with or without treatment with other conventional anticancer treatments, e.g. , chemotherapy, radiotherapy, viral therapies, hormonal therapies, as well as other immunotherapies and anti-chemorepellant therapies.

Abstract: The invention provides a detachable wind guard for a flute-type instrument comprising an elongate, arcuate cover configured to wrap over a flute barrel. The cover has a center section with a radius larger than the radius of the flute barrel and includes a tapered, recessed facing edge configured to leave an embouchure hole uncovered. A domed apex of the center section is sized to accommodate a microphone, and a microphone clip is coupled inside the domed apex. End sections taper to a radius sized to conform to the flute barrel. An elongate, arcuate holder positioned opposite the cover has a radius sized to conform to the flute barrel. A connector pin passes through knuckles on both the cover and holder to form a hinge that allows the wind guard to open in a clamshell manner. Torsion springs around the connector pin bias the holder in a closed position.

Abstract: The invention described herein relates to methods for treating cancer in a subject by administering an effective amount of a CXCL12 signaling inhibitor and a subtherapeutic amount of an anti-cancer agent, e.g., a chemotherapeutic agent.

Abstract: The invention provides a detachable wind guard for a flute-type instrument comprising an elongate, arcuate cover configured to wrap over a flute barrel. The cover has a center section with a radius larger than the radius of the flute barrel and includes a tapered, recessed facing edge configured to leave an embouchure hole uncovered when the wind guard is attached to the flute barrel. End sections taper to a radius sized to conform to the flute barrel. An elongate, arcuate holder positioned opposite the cover has a radius sized to conform to the flute barrel. A connector pin passes through knuckles on both the cover and holder to form a hinge that allows the wind guard to open in a clamshell manner. Torsion springs around the connector pin bias the holder in a closed position.

Abstract: Described herein are unit-dose formulations of 1, 1?-[1,4-phenylenebis (methylene)]-bis- 1,4,8,1 l-tetraazacyclotet-radecane (“AMD3100”) and uses thereof as an anti-fugetactic agent.

Abstract: The invention described herein relates to methods and compositions for treating cancer in a patient by administering an effective amount of cytokine receptor modified immune cells.

Abstract: The invention described herein relates to compositions for treating cancer in a patient, or a tumor cell, by administering an effective amount of AMD3100 over a period of time.

Abstract: The invention described herein relates to methods and compositions for treating cancer in a patient or a tumor cell by administering an effective amount of an anti-fugetactic agent and an additional anti-cancer agent.

Abstract: The invention described herein relates to methods and compositions for treating cancer in a patient, or a tumor cell, by administering an effective amount of an anti-fugetactic agent and an immunotherapy agent.

Abstract: A fastening system and method to removably attach change part components to a capping or filling machine in order to adapt a general purpose machine for use with a specific size or shape container. The fastening system and method uses magnetic forces to pull component parts into alignment and to interlock portions of interchangeable components. In addition, a blocking component is interposed between two other interchangeable component parts or within mushroom slots, securing the components in place, aided by biasing magnets. This system and method relies on a combination of mechanical and magnetic forces by using mechanical forces to reinforce or supplement biasing magnetic forces, and vice versa, creating a durable connection that will withstand the rigors of the filling and capping process, yet which is simple to assemble and disassemble without tools. The less intricate component parts are less prone to damage during assembly, use or disassembly.

Abstract: An encapsulated windshield molding surrounds at least a portion of the peripheral edge of the windshield and includes one or more seals, such as multiple lip or whisker-type seals. The encapsulated molding aims to provide a water-tight installation of the windshield into the windshield opening of the vehicle and allows for butyl-free or adhesive-free restraint of the windshield.

Abstract: A fastening system and method to removably attach change part components to a capping or filling machine in order to adapt a general purpose machine for use with a specific size or shape container. The fastening system and method uses magnetic forces to pull component parts into alignment and to interlock portions of interchangeable components. In addition, a blocking component is interposed between two other interchangeable component parts or within mushroom slots, securing the components in place, aided by biasing magnets. This system and method relies on a combination of mechanical and magnetic forces by using mechanical forces to reinforce or supplement biasing magnetic forces, and vice versa, creating a durable connection that will withstand the rigors of the filling and capping process, yet which is simple to assemble and disassemble without tools. The less intricate component parts are less prone to damage during assembly, use, or disassembly.