Patents by Inventor Patrick Schweizer
Patrick Schweizer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10254273Abstract: The present invention relates to an in vitro method for evaluating the anti- or pro-arrhythmic potential, cardiotoxicity and/or modulation capacity of cardiomyocyte function of compound(s). The present invention also relates to compound(s) identified or evaluated in the method of the invention for use in the treatment of a heart disease. The present invention further relates to the use of the density change of cardiac Nav 1.5 sodium channels in intercalated discs of cardiomyocytes as marker and/or diagnostic for the anti- or pro-arrhythmic potential of a compound, the cardiotoxicity of a compound or modulation capacity of cardiomyocyte function by said compound, and/or in preclinical assessment for cardiac liability of compounds and cardio-safety assessment. The present invention further relates to a kit for evaluating the anti- or pro-arrhythmic potential, cardiotoxicity and/or modulation capacity of cardiomyocyte function of compound(s).Type: GrantFiled: August 11, 2015Date of Patent: April 9, 2019Assignee: RUPRECHT-KARLS-UNIVERSITÄT HEIDELBERGInventors: Michael Koenen, Pessah Yampolsky, Patrick A. Schweizer, Dierk Thomas, Hugo A. Katus
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Publication number: 20170269064Abstract: The present invention relates to an in vitro method for evaluating the anti- or pro-arrhythmic potential, cardiotoxicity and/or modulation capacity of cardiomyocyte function of compound(s). The present invention also relates to compound(s) identified or evaluated in the method of the invention for use in the treatment of a heart disease. The present invention further relates to the use of the density change of cardiac Nav 1.5 sodium channels in intercalated discs of cardiomyocytes as marker and/or diagnostic for the anti- or pro-arrhythmic potential of a compound, the cardiotoxicity of a compound or modulation capacity of cardiomyocyte function by said compound, and/or in preclinical assessment for cardiac liability of compounds and cardio-safety assessment. The present invention further relates to a kit for evaluating the anti- or pro-arrhythmic potential, cardiotoxicity and/or modulation capacity of cardiomyocyte function of compound(s).Type: ApplicationFiled: August 11, 2015Publication date: September 21, 2017Inventors: Michael KOENEN, Pessah YAMPOLSKY, Patrick A. SCHWEIZER, Dierk THOMAS, Hugo A. KATUS
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Publication number: 20170124205Abstract: A computer-implemented method to retrieve results for a travel search task executed on a computer system hosting a travel meta-search engine comprises obtaining a travel search task specifying one or more values of each search task parameter of a set travel search task parameters, obtaining search task normalization information for the search task, normalizing the search task, wherein normalizing the search task includes adapting at least one search parameter of the search task based on the search task normalization information, determining a cache key corresponding to the normalized travel search task, determining if a cache of the computer system hosting a travel meta-search engine includes a search result for the normalized search task, the cache including search results of previous travel search tasks indexed by a cache key and if the cache includes a search result for the normalized search task, retrieving the search result from the cache.Type: ApplicationFiled: May 28, 2014Publication date: May 4, 2017Inventors: Naren SHAAM, Patrick SCHWEIZER, Benjamin EMDE
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Patent number: 9222104Abstract: The present invention relates to the creation of broad-spectrum resistance in transgenic plants by inserting inhibitory nucleic acid sequences inhibiting the expression of fungal genes. The nucleic acid sequences of genes which are crucial to development, growth and profilation of fungi, i.e. sequences of genes with an essential function in fungi, are often conserved and/or have a high sequence identity. Regions having a particularly high sequence identity between various fungi are used in order to produce inhibitory gene constructs, e.g. on basis of antisense, siRNA, shRNA, ribozyme technology and other technologies imparting the inhibition of the expression and activation of genes. Since said methods base on the sequence-specific hybridization of the inhibitory RNA molecules with respective target sequences in certain fungal genes, the expression of all corresponding genes from various fungi is thus inhibited as well.Type: GrantFiled: March 12, 2009Date of Patent: December 29, 2015Assignee: The Leibniz Institute of Plant Genetics and Crop Plant ResearchInventors: Patrick Schweizer, Goetz Hensel, Alexandra Gay, Jochen Kumlehn
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Publication number: 20140351037Abstract: Among other things, information is received from a user interacting with a user interface about a trip that is being planned from an origin to a destination, the information including a user indication of travel modes to be considered in planning the trip and the possible travel modes including at least three of bus, train, car, water, and air. Two or more alternative travel options are determined each including two or more of the modes based on the received information; and the options are presented to the user through the user interface.Type: ApplicationFiled: May 22, 2014Publication date: November 27, 2014Applicant: GOEURO CORP.Inventors: Naren Shaam, Patrick Schweizer, Benjamin Emde
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Publication number: 20140149157Abstract: Among other things, information is received from a user interacting with a user interface about a trip that is being planned from an origin to a destination, the information including a user indication of travel modes to be considered in planning the trip and the possible travel modes including at least three of bus, train, car, water, and air. Two or more alternative travel options are determined each including two or more of the modes based on the received information; and the options are presented to the user through the user interface.Type: ApplicationFiled: November 26, 2013Publication date: May 29, 2014Inventors: Naren Shaam, Patrick Schweizer, Tim Claydon
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Patent number: 8735654Abstract: The invention relates to a method of generating or increasing a pathogen resistance in plants by reducing the expression of at least one Armadillo repeat polypeptide or a functional equivalent thereof. The invention relates to novel nucleic acid sequences coding for a Hordeum vulgare Armadillo repeat (HvARM) polynucleotide and describes homologous sequences (ARM1) thereof, and to their use in methods for obtaining a pathogen resistance in plants e, and to nucleic acid constructs, expression cassettes and vectors which comprise these sequences and which are suitable for mediating a fungal resistance in plants. The invention furthermore relates to transgenic organisms, in particular plants, which are transformed with these expression cassettes or vectors, and to cultures, parts or transgenic propagation material derived therefrom.Type: GrantFiled: November 29, 2012Date of Patent: May 27, 2014Assignee: BASF Plant Science GmbHInventors: Dimitar Douchkov, Patrick Schweizer, Uwe Zierold
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Publication number: 20140137284Abstract: The present invention relates to a method of producing a transgenic plant cell, a transgenic plant or a transgenic part thereof having an increased resistance to pathogens, wherein the content and/or activity of a receptor-like protein kinase is increased.Type: ApplicationFiled: November 7, 2013Publication date: May 15, 2014Applicant: BASF Plant Science Company GmbHInventors: Holger SCHULTHEISS, Tobias MENTZEL, Patrick SCHWEIZER, Dimitar DOUCHKOV, Axel HIMMELBACH
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Patent number: 8592652Abstract: The invention relates to a method of generating or increasing a pathogen resistance in plants by reducing the expression of at least one subtilisin polypeptide or a functional equivalent thereof. The invention relates to novel nucleic acid sequences coding for a Hordeum vulgare subtilisin (HvRNR9) and Triticum aestivum subtilisin (TaRNR9) polynucleotide and describes homologous sequences (RNR9) thereof, and to their use in methods for obtaining a pathogen resistance in plants, and to nucleic acid constructs, expression cassettes and vectors which comprise these sequences and which are suitable for mediating a fungal resistance in plants. The invention furthermore relates to transgenic organisms, in particular plants, which are transformed with these expression cassettes or vectors, and to cultures, parts or transgenic propagation material derived therefrom.Type: GrantFiled: January 15, 2008Date of Patent: November 26, 2013Assignee: BASF Plant Science GmbHInventors: Markus Frank, Patrick Schweizer, Dimitar Douchkov
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Patent number: 8362323Abstract: The invention relates to a method of generating or increasing a pathogen resistance in plants by reducing the expression of at least one Armadillo repeat polypeptide or a functional equivalent thereof. The invention relates to novel nucleic acid sequences coding for a Hordeum vulgare Armadillo repeat (HvARM) polynucleotide and describes homologous sequences (ARM1) thereof, and to their use in methods for obtaining a pathogen resistance in plants e, and to nucleic acid constructs, expression cassettes and vectors which comprise these sequences and which are suitable for mediating a fungal resistance in plants. The invention furthermore relates to transgenic organisms, in particular plants, which are transformed with these expression cassettes or vectors, and to cultures, parts or transgenic propagation material derived therefrom.Type: GrantFiled: October 27, 2006Date of Patent: January 29, 2013Assignee: BASF Plant Science GmbHInventors: Dimitar Douchkov, Patrick Schweizer, Uwe Zierold
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Patent number: 8329988Abstract: The invention relates to a method of increasing the resistance to one or more penetrating pathogen(s) in a monocotyledonous or dicotyledonous plant or a part of a plant, for example in an organ, tissue, a cell or a part of a plant cell, for example in an organell, wherein a DNA sequence which codes for an armadillo repeat ARM1 protein and which mediates an increased pathogen resistance, preferably an increased resistance to fungal pathogens, is increased into, and expressed in, the plant or plant cell; or wherein an endogenous DNA sequence which codes for an armadillo repeat ARM1 protein and which mediates an increased pathogen resistance, preferably an increased resistance to fungal pathogens, is increased in the plant or plant cell in comparison with the original, or wild-type, plant, or wherein the endogenous gene sequence or preferably the 5?-untranslated region (5?UTR) is modified in comparison with the original sequence.Type: GrantFiled: October 12, 2007Date of Patent: December 11, 2012Assignee: BASF Plant Science GmbHInventors: Markus Frank, Patrick Schweizer, Dimitar Douchkov
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Patent number: 8222486Abstract: The present invention relates to a method of increasing the pathogen resistance in transgenic plants and/or plant cells, where a DNA sequence which codes for a protein with a leucine-rich-repeat (LRR) domain and/or a kinase activity is introduced into the plant or plant cell and expressed therein. The present invention also relates to the use of nucleic acids which code for such a protein, for the generation of transgenic plants or plant cells with an increased pathogen resistance. The present invention furthermore relates to nucleic acid sequences which code for a protein which confers an increased pathogen resistance in plants.Type: GrantFiled: August 22, 2007Date of Patent: July 17, 2012Assignee: BASF Plant Science GmbHInventors: Dimitar Douchkov, Patrick Schweizer
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Patent number: 8178751Abstract: The invention relates to a method of generating or increasing a pathogen resistance in plants by reducing the expression of at least one stomatin polypeptide or a functional equivalent thereof. The invention relates to novel nucleic acid sequences coding for a Hordeum vulgare stomatin (HvSTM1) polynucleotide and describes homologous sequences (STM1) thereof, and to their use in methods for obtaining a pathogen resistance in plants, and to nucleic acid constructs, expression cassettes and vectors which comprise these sequences and which are suitable for mediating a fungal resistance in plants. The invention furthermore relates to transgenic organisms, in particular plants, which are transformed with these expression cassettes or vectors, and to cultures, parts or transgenic propagation material derived therefrom.Type: GrantFiled: January 4, 2007Date of Patent: May 15, 2012Assignee: BASF Plant Science GmbHInventors: Markus Frank, Patrick Schweizer, Dimitar Douchkov
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Publication number: 20110067144Abstract: The present invention relates to the creation of broad-spectrum resistance in transgenic plants by inserting inhibitory nucleic acid sequences inhibiting the expression of fungal genes. The nucleic acid sequences of genes which are crucial to development, growth and profilation of fungi, i.e. sequences of genes with an essential function in fungi, are often conserved and/or have a high sequence identity. Regions having a particularly high sequence identity between various fungi are used in order to produce inhibitory gene constructs, e.g. on basis of antisense, siRNA, shRNA, ribozyme technology and other technologies imparting the inhibition of the expression and activation of genes. Since said methods base on the sequence-specific hybridization of the inhibitory RNA molecules with respective target sequences in certain fungal genes, the expression of all corresponding genes from various fungi is thus inhibited as well.Type: ApplicationFiled: March 12, 2009Publication date: March 17, 2011Inventors: Patrick Schweizer, Goetz Hensel, Alexandra Gay, Jochen Kumlehn
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Patent number: 7834243Abstract: The invention relates to promoter regions, under the control of which transgenes can be expressed in plants in an epidermis-specific and pathogen-inducible manner. The invention also relates to recombinant nucleic acid molecules, including the promoters, to transgenic plants and plant cells, transformed with said the nucleic acid molecules and to methods for producing the same. The invention also relates to nucleic acid molecules, including a promoter according to the invention, nucleic acid sequences or transgenes, which can convey resistance to pathogens, plants and cell plants, transformed with the nucleic acid molecules and methods for producing the same. The invention also relates to the use of the promoter region according to the invention for analyzing pathogen-induced signal transduction pathways in plant cells.Type: GrantFiled: May 30, 2006Date of Patent: November 16, 2010Assignee: Leibniz-Institut für Pflanzengenetik Und Kulturpflanzenforschung (IPK)Inventors: Patrick Schweizer, Axel Himmelbach, Lothar Altschmied, Helmut Maucher
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Publication number: 20100170005Abstract: The invention relates to a method of generating or increasing a pathogen resistance in plants by reducing the expression of at least one subtilisin polypeptide or a functional equivalent thereof. The invention relates to novel nucleic acid sequences coding for a Hordeum vulgare subtilisin (HvRNR9) and Triticum aestivum subtilisin (TaRNR9) polynucleotide and describes homologous sequences (RNR9) thereof, and to their use in methods for obtaining a pathogen resistance in plants, and to nucleic acid constructs, expression cassettes and vectors which comprise these sequences and which are suitable for mediating a fungal resistance in plants. The invention furthermore relates to transgenic organisms, in particular plants, which are transformed with these expression cassettes or vectors, and to cultures, parts or transgenic propagation material derived therefrom.Type: ApplicationFiled: January 15, 2008Publication date: July 1, 2010Inventors: Markus Frank, Patrick Schweizer, Dimitar Douchkov
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Publication number: 20100071089Abstract: The invention relates to a method of increasing the resistance to one or more penetrating pathogen(s) in a monocotyledonous or dicotyledonous plant or a part of a plant, for example in an organ, tissue, a cell or a part of a plant cell, for example in an organell, wherein a DNA sequence which codes for an armadillo repeat ARM1 protein and which mediates an increased pathogen resistance, preferably an increased resistance to fungal pathogens, is increased into, and expressed in, the plant or plant cell; or wherein an endogenous DNA sequence which codes for an armadillo repeat ARM1 protein and which mediates an increased pathogen resistance, preferably an increased resistance to fungal pathogens, is increased in the plant or plant cell in comparison with the original, or wild-type, plant, or wherein the endogenous gene sequence or preferably the 5?-untranslated region (5?UTR) is modified in comparison with the original sequence.Type: ApplicationFiled: October 12, 2007Publication date: March 18, 2010Applicant: BASF PLANT SCIENCE GMBHInventors: Markus Frank, Patrick Schweizer, Dimitar Douchkov
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Publication number: 20100011467Abstract: The present invention relates to a method of increasing the pathogen resistance in transgenic plants and/or plant cells, where a DNA sequence which codes for a protein with a leucine-rich-repeat (LRR) domain and/or a kinase activity is introduced into the plant or plant cell and expressed therein. The present invention also relates to the use of nucleic acids which code for such a protein, for the generation of transgenic plants or plant cells with an increased pathogen resistance. The present invention furthermore relates to nucleic acid sequences which code for a protein which confers an increased pathogen resistance in plants.Type: ApplicationFiled: August 22, 2007Publication date: January 14, 2010Applicant: BASF Plant Science GmbHInventors: Dimitar Douchkov, Patrick Schweizer
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Patent number: 7608756Abstract: The invention relates to methods of producing transgenic plants including pathogen resistant plants with recombinant nucleic acid molecules comprising promoter regions which provides expression of a desired transgene in epidermis-specific manner, and transgenic plants produced by said methods.Type: GrantFiled: October 7, 2004Date of Patent: October 27, 2009Assignees: IPK Institut für Pflanzengenetik und Kulturpflanzenforschung, Max-Planck-Gesellschaft zur Förderung der Wissenschaften E.V., Universität ZürichInventors: Patrick Schweizer, Robert Dudler, Paul Schulze-Lefert, Ralph Panstruga
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Publication number: 20090241215Abstract: The invention relates to a method of generating or increasing a pathogen resistance in plants by reducing the expression of at least one Armadillo repeat polypeptide or a functional equivalent thereof. The invention relates to novel nucleic acid sequences coding for a Hordeum vulgare Armadillo repeat (HvARM) polynucleotide and describes homologous sequences (ARM1) thereof, and to their use in methods for obtaining a pathogen resistance in plants e, and to nucleic acid constructs, expression cassettes and vectors which comprise these sequences and which are suitable for mediating a fungal resistance in plants. The invention furthermore relates to transgenic organisms, in particular plants, which are transformed with these expression cassettes or vectors, and to cultures, parts or transgenic propagation material derived therefrom.Type: ApplicationFiled: October 27, 2006Publication date: September 24, 2009Applicant: BASF Plant Science GmbHInventors: Dimitar Douchkov, Patrick Schweizer, Uwe Zierold