Patents by Inventor Patrick Seale

Patrick Seale has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Molecular control of brown fat differentiation and energy expenditure
    Patent number: 9074012
    Abstract: The invention provides methods and compositions for inducing brown fat cell differentiation through modulation of Prdm 16 activity or expression. Also provided are methods for preventing or treating obesity or an obesity related disorder in a subject through stimulation of Prdm 16 expression or activity. Further provided are methods for identifying compounds that are capable of modulating Prdm 16 expression or activity.
    Type: Grant
    Filed: October 17, 2007
    Date of Patent: July 7, 2015
    Assignee: Dana-Farber Cancer Institute, Inc.
    Inventors: Patrick Seale, Bruce M. Spiegelman
  • Molecular Control of Brown Fat Differentiation and Engergy Expenditure
    Publication number: 20110059051
    Abstract: The invention provides methods and compositions for inducing brown fat cell differentiation through modulation of Prdm 16 activity or expression. Also provided are methods for preventing or treating obesity or an obesity related disorder in a subject through stimulation of Prdm 16 expression or activity. Further provided are methods for identifying compounds that are capable of modulating Prdm 16 expression or activity.
    Type: Application
    Filed: October 17, 2007
    Publication date: March 10, 2011
    Applicant: Dana-Farber Cancer Institute, Inc.
    Inventors: Bruce M. Spiegelman, Patrick Seale
  • Growth and differentiation of adult muscle stem cells with activators or inhibitors of Wnt signaling
    Patent number: 7541183
    Abstract: Compositions and methods for modulating proliferation and/or lineage commitment of stem cells by modulating the Wnt signalling pathways. Modulators of the Wnt signalling pathways and screening methods to identify modulators are also provided. The methods of the invention may be conducted in vitro or in vivo to induce or inhibit stem cell proliferation and/or lineage commitment, and are particularly useful for in vivo stimulation of proliferation and/or lineage commitment of resident stem cells in a tissue.
    Type: Grant
    Filed: December 22, 2005
    Date of Patent: June 2, 2009
    Assignee: Ottawa Health Research Institute
    Inventors: Michael Rudnicki, Patrick Seale, Anna Polesskaya, Anouk Fortin
  • Pax-encoding vector and use thereof
    Patent number: 7384784
    Abstract: The present invention provides cells transformed with a nucleotide sequence encoding Pax7, Pax3 or both. The present invention also pertains to Pax-encoding vector that comprises a sequence encoding Pax7, Pax3 or an active variant or fragment thereof, which can be used to induce myogenic differentiation of stem cells. The present invention further pertains to methods of preparing the Pax-encoding vector. Also provided is a method of inducing myogenic differentiation in stem cells and treating a subject with the cells.
    Type: Grant
    Filed: April 30, 2004
    Date of Patent: June 10, 2008
    Assignee: Ottawa Health Research Institute
    Inventors: Michael A. Rudnicki, Patrick Seale
  • Methods and compositions for modulating stem cell growth and differentiation
    Publication number: 20060171931
    Abstract: Compositions and methods for modulating proliferation and/or lineage commitment of stem cells by modulating the Wnt signalling pathways. Modulators of the Wnt signalling pathways and screening methods to identify modulators are also provided. The methods of the invention may be conducted in vitro or in vivo to induce or inhibit stem cell proliferation and/or lineage commitment, and are particularly useful for in vivo stimulation of proliferation and/or lineage commitment of resident stem cells in a tissue.
    Type: Application
    Filed: December 22, 2005
    Publication date: August 3, 2006
    Inventors: Michael Rudnicki, Patrick Seale, Anna Polesskaya, Anouk Fortin
  • Pax-encoding vector and use thereof
    Publication number: 20050042637
    Abstract: The present invention provides cells transformed with a nucleotide sequence encoding Pax7, Pax3 or both. The present invention also pertains to Pax-encoding vector that comprises a sequence encoding Pax7, Pax3 or an active variant or fragment thereof, which can be used to induce myogenic differentiation of stem cells. The present invention further pertains to methods of preparing the Pax-encoding vector. Also provided is a method of inducing myogenic differentiation in stem cells and treating a subject with the cells.
    Type: Application
    Filed: April 30, 2004
    Publication date: February 24, 2005
    Inventors: Michael Rudnicki, Patrick Seale
  • Pax-encoding vector and use thereof
    Publication number: 20040120933
    Abstract: The present invention provides a Pax-encoding vector that comprises a sequence encoding a Pax7, Pax3 or an active variant or fragment thereof, which can be used to induce myogenic differentiation of adult pluripotent stem cells. The present invention further pertains to methods of preparing the Pax-encoding vector. Also provided is a method of inducing myogenic differentiation of adult pluripotent stem cells.
    Type: Application
    Filed: September 17, 2002
    Publication date: June 24, 2004
    Inventors: Michael A. Rudnicki, Patrick Seale
  • Pax-encoding vector and use thereof
    Publication number: 20030124102
    Abstract: The present invention provides a Pax-encoding vector that comprises a sequence encoding a Pax7, Pax3 or an active variant or fragment thereof, which can be used to induce myogenic differentiation of adult pluripotent stem cells. The present invention further pertains to methods of preparing the Pax-encoding vector. Also provided is a method of inducing myogenic differentiation of adult pluripotent stem cells.
    Type: Application
    Filed: September 17, 2002
    Publication date: July 3, 2003
    Inventors: Michael A. Rudnicki, Patrick Seale