Patents by Inventor Patrick Stern

Patrick Stern has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cre-lox based gene knockdown constructs and methods of use thereof
    Patent number: 9043994
    Abstract: The present invention relates to vectors, compositions and methods for conditional, Cre-lox regulated, RNA interference. The vectors allow for spatial and temporal control of miRNA expression in vivo.
    Type: Grant
    Filed: March 12, 2008
    Date of Patent: June 2, 2015
    Assignee: Massachusetts Institute of Technology
    Inventors: Patrick Stern, Richard Hynes
  • LENTIVIRAL VECTORS THAT PROVIDE IMPROVED EXPRESSION AND REDUCED VARIEGATION AFTER TRANSGENESIS
    Publication number: 20130024958
    Abstract: The present invention provides new lentiviral vectors that include an anti-repressor element (ARE) and, optionally, a scaffold attachment region (SAR). The lentiviral vectors provide expression of a heterologous nucleic acid in at least 50% of the cells of multiple cell types when used for lentiviral transgenesis. In certain embodiments of the invention the heterologous nucleic acid encodes an RNAi agent such as an shRNA. The invention further provides transgenic nonhuman animals generated using a lentiviral vector that includes an ARE and optional SAR. In addition, the invention provides a variety of methods for using the vectors including for achieving gene silencing in eukaryotic cells and transgenic animals, and methods of treating disease. The invention also provides animal models of human disease in which one or more genes is functionally silenced using a lentiviral vector of the invention.
    Type: Application
    Filed: May 3, 2012
    Publication date: January 24, 2013
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Patrick Stern, Stephen Kissler
  • CRE-LOX BASED GENE KNOCKDOWN CONSTRUCTS AND METHODS OF USE THEREOF
    Publication number: 20120214242
    Abstract: The present invention relates to vectors, compositions and methods for conditional, Cre-lox regulated, RNA interference. The vectors allow for spatial and temporal control of miRNA expression in vivo.
    Type: Application
    Filed: January 12, 2012
    Publication date: August 23, 2012
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Patrick Stern, Richard Hynes
  • Cre-lox based gene knockdown constructs and methods of use thereof
    Publication number: 20090217397
    Abstract: The present invention relates to vectors, compositions and methods for conditional, Cre-lox regulated, RNA interference. The vectors allow for spatial and temporal control of miRNA expression in vivo.
    Type: Application
    Filed: June 11, 2007
    Publication date: August 27, 2009
    Inventors: Patrick Stern, Richard Hynes
  • Lentiviral Vectors That Provide Improved Expression And Reduced Variegation After Transgenesis
    Publication number: 20090217399
    Abstract: The present invention provides new lentiviral vectors that include an anti-repressor element (ARE) and, optionally, a scaffold attachment region (SAR). The lentiviral vectors provide expression of a heterologous nucleic acid in at least 50% of the cells of multiple cell types when used for lentiviral transgenesis. In certain embodiments of the invention the heterologous nucleic acid encodes an RNAi agent such as an shRNA. The invention further provides transgenic nonhuman animals generated using a lentiviral vector that includes an ARE and optional SAR. In addition, the invention provides a variety of methods for using the vectors including for achieving gene silencing in eukaryotic cells and transgenic animals, and methods of treating disease. The invention also provides animal models of human disease in which one or more genes is functionally silenced using a lentiviral vector of the invention.
    Type: Application
    Filed: March 16, 2007
    Publication date: August 27, 2009
    Applicant: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
    Inventors: Patrick Stern, Stephen Kissler
  • Cre-lox based gene knockdown constructs and methods of use thereof
    Publication number: 20090187997
    Abstract: The present invention relates to vectors, compositions and methods for conditional, Cre-lox regulated, RNA interference. The vectors allow for spatial and temporal control of miRNA expression in vivo.
    Type: Application
    Filed: March 12, 2008
    Publication date: July 23, 2009
    Inventors: Patrick Stern, Richard Hynes