Abstract: The present invention discloses a flow cell optical detection system comprising a light source, a flow cell and a light detector, wherein the light detector is arranged in a separate detector unit that is arranged to be releasably attached to a detector interface, the detector interface being in optical communication with the light source and comprises optical connectors for optically connecting the flow cell and the detector unit in the light path from the light source, and wherein the flow cell is an interchangeable unit arranged to be held in position by the detector unit when attached to the detector interface.

Abstract: A bioreactor system comprising a base station comprising a control system, a tray arranged to be provided on the base station and arranged to house a bioreactor bag, wherein said base station comprises at least one temperature sensor means and in that said tray comprises at least one opening for receiving said temperature sensor means such that it will contact a surface of a bioreactor provided in the tray.

Abstract: A rigid housing comprising a bottom part and at least one wall part, said bottom part and said at least one wall part together defining an internal volume when the bottom part is provided below the at least one wall part in a processing position, said rigid housing being arranged for holding a flexible bag within the internal volume, wherein the bottom part is rotatable about an axis of rotation, wherein said axis of rotation is substantially parallel to a longitudinal axis of said rigid housing such that the bottom part can be provided in a loading position in which the bottom part has been rotated out from the position below the at least one wall part.

Abstract: The invention relates to a bag locking mechanism comprising, a fixed locking means (106), provided with a first abutment surface (116), a movable locking means (108; 208), which is movable between a locking position and a releasing position, and a second abutment surface (118; 218) arranged on the movable locking means (108; 208). The fixed locking means (106) defines by its configuration, at least partly a restricted locking space (114), in which the movable locking means (108; 208) is movable between the locking and releasing position.

Abstract: A temperature sensor means comprising a thermally conducting layer arranged to face the surface to be measured, a thermally insulating layer attached to the thermally conducting layer on the opposite side to the surface to be measured, a temperature sensor provided between the thermally conducting layer and the thermally insulating layer and being completely surrounded on all its sides by either the thermally conducting or the thermally insulating layers.

Abstract: A temperature sensor means comprising a thermally conducting layer arranged to face the surface to be measured, a thermally insulating layer attached to the thermally conducting layer on the opposite side to the surface to be measured, a temperature sensor provided between the thermally conducting layer and the thermally insulating layer and being completely surrounded on all its sides by either the thermally conducting or the thermally insulating layers.

Abstract: The present invention discloses a flow cell optical detection system comprising a light source, a flow cell and a light detector, wherein the light detector is arranged in a separate detector unit that is arranged to be releasably attached to a detector interface, the detector interface being in optical communication with the light source and comprises optical connectors for optically connecting the flow cell and the detector unit in the light path from the light source, and wherein the flow cell is an interchangeable unit arranged to be held in position by the detector unit when attached to the detector interface.

Abstract: The present invention discloses a flow cell optical detection system comprising a light source, a flow cell and a light detector, wherein the light detector is arranged in a separate detector unit that is arranged to be releasably attached to a detector interface, the detector interface being in optical communication with the light source and comprises optical connectors for optically connecting the flow cell and the detector unit in the light path from the light source, and wherein the flow cell is an interchangeable unit arranged to be held in position by the detector unit when attached to the detector interface.

Abstract: The invention discloses a distribution plate for supplying crossflow filtration cassettes, which comprises a surface, two opposite end walls, two opposite side walls, a feed channel in fluid communication with a feed inlet port and with a plurality of feed apertures; a retentate channel in fluid communication with a retentate outlet port, and with a plurality of retentate apertures; and a permeate channel in fluid communication with two permeate outlet ports and with a plurality of permeate apertures; wherein the feed channel, the retentate channel and the permeate channel extend in a direction essentially parallel with one or both side walls; wherein the feed apertures are grouped at a first area on the surface, the retentate apertures are grouped at a second area on the surface; wherein the permeate apertures are located at the first and/or the second area; and wherein a plurality of permeate connector channels extend inside the plate from at least one region of the permeate channel, adjacent the permeate o

Abstract: A robust crossflow filtration cassette holder, allowing easy mounting and removal of filtration cassettes. The cassette holder comprises a distributor plate, an end-plate, a plurality of essentially parallel tie rods connecting the distributor plate with the end-plate, and a compression plate slidably mounted on the tie rods between the distributor plate and the end plate, wherein at least one of the tie rods is movable in its entirety between an open position or orientation, allowing mounting or removal of a filtration cassette, and a closed position or orientation, in which the movable tie rod is in engaged connection with the cassette and locks it in the holder by a locking means.

Abstract: The invention relates to a system and method for mixing two or more solutions. Provided is an integrated system for generating a homogeneous solution from two or more input solutions, comprising: a mixer chamber containing a magnetic stir bar; a means for rotating the magnetic stir bar; and an user interface for input a chosen flow rate. The mixer chamber comprises a mixer chamber body including a movable upper part which defines a mixer chamber volume; one or more solution inlets; an solution outlet; the magnetic stir bar; and a means for adjusting the mixer chamber volume. In response to the input flow rate, the mixing chamber volume is adjusted to an optimal volume, by the movement of the movable upper part, controlled by the means for adjusting the mixer chamber volume. Also provided are methods of using the system to achieve homogeneous mixing of two or more solutions.

Abstract: A temperature sensor means comprising a thermally conducting layer arranged to face the surface to be measured, a thermally insulating layer attached to the thermally conducting layer on the opposite side to the surface to be measured, a temperature sensor provided between the thermally conducting layer and the thermally insulating layer and being completely surrounded on all its sides by either the thermally conducting or the thermally insulating layers.

Abstract: A bioreactor system comprising a base station comprising a control system, a tray arranged to be provided on the base station and arranged to house a bioreactor bag, wherein said base station comprises at least one temperature sensor means and in that said tray comprises at least one opening for receiving said temperature sensor means such that it will contact a surface of a bioreactor provided in the tray.

Abstract: The invention relates to a bag locking mechanism comprising, a fixed locking means (106), provided with a first abutment surface (116), a movable locking means (108; 208), which is movable between a locking position and a releasing position, and a second abutment surface (118; 218) arranged on the movable locking means (108; 208). The fixed locking means (106) defines by its configuration, at least partly a restricted locking space (114), in which the movable locking means (108; 208) is movable between the locking and releasing position.

Abstract: The invention discloses a distribution plate for supplying crossflow filtration cassettes, which comprises a surface, two opposite end walls, two opposite side walls, a feed channel in fluid communication with a feed inlet port and with a plurality of feed apertures; a retentate channel in fluid communication with a retentate outlet port, and with a plurality of retentate apertures; and a permeate channel in fluid communication with two permeate outlet ports and with a plurality of permeate apertures; wherein the feed channel, the retentate channel and the permeate channel extend in a direction essentially parallel with one or both side walls; wherein the feed apertures are grouped at a first area on the surface, the retentate apertures are grouped at a second area on the surface; wherein the permeate apertures are located at the first and/or the second area; and wherein a plurality of permeate connector channels extend inside the plate from at least one region of the permeate channel, adjacent the permeate o

Abstract: An adjustable holder (1) for a concave holographic grating (2) for enabling the correct positioning of the grating vis-à-vis a light entrance port (15) and a light exit port (20), characterized in, that it comprises a grating hinge (10) fixed to said grating, said grating hinge (10) enabling rotational adjustment of the grating position with respect to said holder (1), the center point of the rotational adjustment being located at the vertex of said grating (2).

Abstract: A robust crossflow filtration cassette holder, allowing easy mounting and removal of filtration cassettes. The cassette holder comprises a distributor plate, an end-plate, a plurality of essentially parallel tie rods connecting the distributor plate with the end-plate, and a compression plate slidably mounted on the tie rods between the distributor plate and the end plate, wherein at least one of the tie rods is movable in its entirety between an open position or orientation, allowing mounting or removal of a filtration cassette, and a closed position or orientation, in which the movable tie rod is in engaged connection with the cassette and locks it in the holder by a locking means.

Abstract: Chromatography column comprising a column tube and at least one adjustable adapter assembly with a plunger that may be positioned at a plurality of longitudinal positions in the column tube, wherein the piston is arranged at the end of a threaded piston rod arranged with the threads engaged by a rotable end cap for enabling longitudinal movement of the piston by turning the end cap, and wherein the adaptor assembly comprises rotation prevention means arranged to prevent rotation of the plunger rod in response to turning of the end cap.

Abstract: A sanitary piston head with a body, said piston head having a fluid-contact end and a drive end and comprising a resilient sealing skirt arranged to provide sealing abutment against the inner wall of a cylinder when said piston head is inserted in said cylinder, wherein the resilient sealing skirt is biased in the sealing direction by a radially biasing element.

Abstract: The invention relates to a system and method for mixing two or more solutions. Provided is an integrated system for generating a homogeneous solution from two or more input solutions, comprising: a mixer chamber containing a magnetic stir bar; a means for rotating the magnetic stir bar; and an user interface for input a chosen flow rate. The mixer chamber comprises a mixer chamber body including a movable upper part which defines a mixer chamber volume; one or more solution inlets; an solution outlet; the magnetic stir bar; and a means for adjusting the mixer chamber volume. In response to the input flow rate, the mixing chamber volume is adjusted to an optimal volume, by the movement of the movable upper part, controlled by the means for adjusting the mixer chamber volume. Also provided are methods of using the system to achieve homogeneous mixing of two or more solutions.