Abstract: The present disclosure relates to porous orthopedic implants made from polymer preforms and a method of manufacturing the same. A polymer material may be formed into a preform, such as by an injection molding process or an additive manufacturing process. In an exemplary embodiment, the overall shape and the porous framework of the preform is predetermined to be substantially the same as the overall shape and the porous framework of the final orthopedic implant. Then, the preform may be pyrolyzed and coated with metal to form the final orthopedic implant.

Abstract: The present disclosure relates to porous orthopedic implants made from polymer preforms and a method of manufacturing the same. A polymer material may be formed into a preform, such as by an injection molding process or an additive manufacturing process. In an exemplary embodiment, the overall shape and the porous framework of the preform is predetermined to be substantially the same as the overall shape and the porous framework of the final orthopedic implant. Then, the preform may be pyrolyzed and coated with metal to form the final orthopedic implant.

Abstract: An implant device 10, 10a including a hollow or planar body 14 or 14a defining a mesh covering. A bioactive agent(s) is incorporated into or onto the body 14. The body 14 can include a woven, knitted, and/or nonwoven fabric 30, 36, 37 and/or a polymeric film 38, each having a plurality of desirably sized openings 18. The implant device 10, 10a is used in combination with a bone implant 16 to define an implant system 12. In one embodiment, the bone implant 16 includes an outer surface 44 that is generally covered by the implant device 10, 10a so that the hollow or planar body 14, 14a covers and conforms to at least a portion of the outer surface 44 of the bone implant 16. After implantation of the implant system 12, a desirable area of the outer surface 44 of the bone implant 16 is in direct contact with bone tissue. This secures primary stability and subsequent bone on- and in-growth for secondary stability.

Abstract: A method for localized treatment using a microneedle array to controllably administer a dose of a bone anabolic drug localized at a dental implant site. The bone anabolic drug enhances alveolar bone growth at the dental implant site. Examples of drugs that may be used include, but are not limited to, bone anabolic drugs (e.g., bone morphogenetic proteins, fibroblast growth factor 2, statins parathyroid hormone), and/or drugs that target cell signalling pathways involved in the regulation of the osteoblastic lineage and function. In one embodiment, the method includes monitoring the dental implant site for periodontal tissue generation sufficient to support a dental implant. When sufficient tissue is generated, the dental implant is surgically inserted in the dental implant site. Additional doses of the bone anabolic drug may be delivered prior to detecting tissue generation.

Abstract: Systems and methods are disclosed for implanting and forming both a polysaccharide fiber and an implant formed of the fiber. In one system, a liquid including polysaccharide and a liquid including a cross linking agent are mixed in a cannula to form a cross linked polysaccharide fiber in the cannula. In another system, a carrier fluid delivers a previously manufactured fiber through a cannula. A cutter is optionally provided on the cannula to sever the fiber after a sufficient length of fiber is implanted.

Abstract: A device for applying a filamentous implant by means of a pressure-generating and fluid-containing unit which is connected to a housing containing the thread to be implanted. The housing opens out into a channel used for delivering the thread externally. The pressure generation unit generates a static pressure on a fluid contained inside the device, said fluid pushing the thread to be implanted through the distal narrowed tip of the channel, towards the exterior or into a tissue or a body cavity. The fluid remains inside the device in the course of this process. The distal end of the device can be plugged in order to prevent the fluid from exiting after application of the implant. The application can be stopped once an adequate quantity of the implant material has been implanted by severing the thread in the vicinity of the distal end of the channel or at the proximal end.

Abstract: A ball-shaped implant made out of a pliable fiber. The fiber is introduced into the body and when it encounters body tissue it folds upon itself to form a ball-shaped implant. A fluid may be placed around the implant either to hold it in place or to add a biologically active agent to the implant. The fiber of the implant may be biodegradable, or hollow and porous to allow for drugs placed inside the fiber to be administered to the body. One end of the fiber may be long enough to extend out of the body for later removal.

Abstract: In the method proposed, the implant material in the form of a fibre is unwound from a bobbin (10) with the aid of a stream of air (24) and injected through a tube (19) into the body (22). In front of the distal opening (20) of the fibre injection tube, the implant material forms a coherent, open-pore structure in the form of a ball of fibre (25). The fibre-injection tube (19) can be a syringe needle, a catheter or an endoscope tube. This enables the implant (25) to be inserted using minimum-invasive surgery. The size and shape of the implant thus produced can be very variable and can be determined intra-operatively. Various implant materials and fibre shapes can be used. Possible applications of the implant are in the filling of body cavities, systems for the controlled release of systemically acting drugs or chemotherapeutic agents, the induction of tissue, cell transplantation and therapeutic embolization.

Abstract: Systems and methods are disclosed for implanting and forming both a polysaccharide fiber and an implant formed of the fiber. In one system, a liquid including polysaccharide and a liquid including a cross linking agent are mixed in a cannula to form a cross linked polysaccharide fiber in the cannula. In another system, a carrier fluid delivers a previously manufactured fiber through a cannula. A cutter is optionally provided on the cannula to sever the fiber after a sufficient length of fiber is implanted. The disclosed methods include a method of forming a polysaccharide fiber in the cannula while the cannula is inserted in a body, and a method of making a cross linked polysaccharide fiber for loading in a delivery system.

Abstract: Systems and methods are disclosed for implanting and forming both a polysaccharide fiber and an implant formed of the fiber. In one system, a liquid including polysaccharide and a liquid including a cross linking agent are mixed in a cannula to form a cross linked polysaccharide fiber in the cannula. In another system, a carrier fluid delivers a previously manufactured fiber through a cannula. A cutter is optionally provided on the cannula to sever the fiber after a sufficient length of fiber is implanted. The disclosed methods include a method of forming a polysaccharide fiber in the cannula while the cannula is inserted in a body, and a method of making a cross linked polysaccharide fiber for loading in a delivery system.