Patents by Inventor Pattie S. Green

Pattie S. Green has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cytoprotective effect of polycyclic phenolic compounds
    Patent number: 6319914
    Abstract: The invention comprises methods for conferring a cytoprotective effect on a population of cells, such as providing a polycyclic phenolic compound in a physiologically acceptable formulation, and administering the formulation in an effective dose to the population of cells.
    Type: Grant
    Filed: July 12, 1999
    Date of Patent: November 20, 2001
    Assignees: Apollo BioPharmaceuticals, Inc., University of Florida Research Foundation, Inc.
    Inventors: James W. Simpkins, Katherine D. Gordon, Pattie S. Green
  • Preservation of tissue during removal storage and implantation
    Patent number: 6207658
    Abstract: A method is provided for preserving tissues during removal, storage and implantation into a subject by enhancing cell viability in a population of graft cells during the transplantation procedure. The method includes selecting an effective dose of a polycylic phenolic compound in a physiologically acceptable formulation and exposing at least the population of graft cells to the formulation containing the compound within a time that is effectively proximate to the transplantation procedure so as to confer cytoprotection on the population of graft cells.
    Type: Grant
    Filed: August 4, 1998
    Date of Patent: March 27, 2001
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: James W. Simpkins, Pattie S. Green, Kelly E. Gridley
  • Neuroprotective effects of polycyclic phenolic compounds
    Patent number: 6197833
    Abstract: A method is provided for conferring neuroprotection on a population of cells in a subject, the method including providing a polycyclic compound having a terminal phenolic group in a structure containing at least a second ring, the compound having a molecular weight of less than 1000 Daltons, the compound not including estrogen compounds including estrogen agonists. The compound may be administered in an effective dose to the population of cells so as to confer neuroprotection. Methods are further provided for treating a neurodegenerative disease in a subject that include providing an effective dose of a formulation containing the compound and administering the dose to the subject.
    Type: Grant
    Filed: August 4, 1998
    Date of Patent: March 6, 2001
    Assignees: Apollo Biopharmaceutics, Inc., University of Florida Research Foundation, Inc.
    Inventors: James W Simpkins, Katherine Gordon, Pattie S. Green
  • Methods and compositions to enhance the cytoprotective effects of polycyclic phenolic compounds through the synergistic interaction with anti-oxidants
    Patent number: 5972923
    Abstract: The present invention concerns methods and compositions for enhancing the cytoprotective effects of polycyclic phenolic compounds through the synergistic interaction with anti-oxidants.
    Type: Grant
    Filed: January 16, 1998
    Date of Patent: October 26, 1999
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: James W. Simpkins, Kelly E. Gridley, Pattie S. Green
  • Neuroprotective effects of polycyclic phenolic compounds
    Patent number: 5859001
    Abstract: This application relates to the use of non-estrogen compounds having a terminal phenol group in a four-ring cyclopentanophenanthrene compound structure for conferring neuroprotection to cells and for the treatment of neurodegenerative diseases.
    Type: Grant
    Filed: July 24, 1996
    Date of Patent: January 12, 1999
    Assignees: University of Florida Research Foundation, Inc., Apollo Genetics
    Inventors: James W Simpkins, Katherine Gordon, Pattie S. Green
  • Preservation of tissue during removal, storage and implantation
    Patent number: 5824672
    Abstract: A method is provided for preserving tissues during removal storage and implantation by enhancing cell viability in a population of graft cells during the transplantation procedure The method includes selecting an effective dose of a cyclopentanophenanthrene compound having a terminal phenol A ring in a physiologically acceptable formulation and exposing at least one of: a donor at an effective dose prior to removal of the cells; the population of cells in an ex vivo storage medium;, and a recipient tissue at an effective time prior to association with the donor graft cells; so as to confer cytoprotection on the population of graft cells.
    Type: Grant
    Filed: January 10, 1997
    Date of Patent: October 20, 1998
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: James W. Simpkins, Pattie S. Green, Kelly E. Gridley