Patents by Inventor Paul A. C. Cloos

Paul A. C. Cloos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Assay of isomerised and/or optically inverted proteins and protein fragments
    Patent number: 7632684
    Abstract: In an in vitro diagnostic test for osteoarthritis or rheumatoid arthritis, the amount or presence in a sample of anisomerised or optically inverted protein fragment is measured which derives from perlecan, bigylcan, decorin, fibrillin-1 or protocadherin or which is a specific sequence from aggrecan, type II collagen, COMP or CILP.
    Type: Grant
    Filed: May 22, 2002
    Date of Patent: December 15, 2009
    Assignee: Nordic Bioscience Diagnostics A/S
    Inventors: Stephan Christgau, Dennis B. Henriksen, Paul A. C. Cloos
  • Assay of isomerised and/or optically inverted proteins and protein fragments
    Patent number: 7354723
    Abstract: Disclosed are compositions and methods for performing an immuno-assay that includes measuring the amount of an isomerised or optically inverted non-collagen protein derived from cartilage.
    Type: Grant
    Filed: May 23, 2002
    Date of Patent: April 8, 2008
    Assignee: Nordic Bioscience Dagnostics A/S
    Inventors: Stephan Christgau, Dennis B. Henriksen, Paul A. C. Cloos
  • Assay of isomerised and/or optically inverted proteins and protein fragments
    Publication number: 20040259172
    Abstract: In an in vitro diagnostic test for osteoarthritis or rheumatoid arthritis, the amount or presence in a sample of anisomerised or optically inverted protein fragment is measured which derives from perlecan, bigylcan, decorin, fibrillin-1 or protocadherin or which is a specific sequence from aggrecan, type II collagen, COMP or CILP.
    Type: Application
    Filed: May 24, 2004
    Publication date: December 23, 2004
    Inventors: Stephan Christgau, Dennis Henriksen, Paul A.C. Cloos
  • Specific autoimmune reactions against isomerised/optically inverted epitopes: application for treatment of autoimmune diseases
    Publication number: 20030216319
    Abstract: Methods and compositions for therapeutic or prophylactic treatment of an autoimmune disease by the selective suppression of autoimmune activity against an auto-antigen, which activity involves immunological reactivity with an epitope containing an isomerised peptide linkage and/or an optically inverted amino acid comprise the use of a protein or peptide or analogue thereof containing an epitope recognised by an auto-reactive immune system component involved in said condition, which epitope contains an isomerised peptide linkage and/or an optically inverted amino acid or comprising a compound which immunologically mimics a said protein or peptide.
    Type: Application
    Filed: February 14, 2003
    Publication date: November 20, 2003
    Inventors: Paul A.C. Cloos, Stephan Christgau