Abstract: The present invention is directed to the anti-LAG-3 antibodies, LAG-3 mAb 1, LAG-3 mAb 2, LAG-3 mAb 4, LAG-3 mAb 5, and LAG-3 mAb 6, and to humanized and chimeric versions of such antibodies. The invention additionally pertains to LAG-3-binding molecules that comprise LAG-3 binding fragments of such anti-LAG-3 antibodies, immunocongugates, and to bispecific molecules, including diabodies, BiTEs, bispecific antibodies, etc., that comprise (i) such LAG-3-binding fragments, and (ii) a domain capable of binding an epitope of a molecule involved in regulating an immune check point present on the surface of an immune cells. The present invention also pertains to methods of detecting LAG-3, as well as methods of using molecules that bind LAG-3 for stimulating immune responses.

Abstract: A method comprises receiving, at a build service of a build server, an external dataset and an adaptor application module, the external dataset being in a specific format, the adaptor application module providing information relevant to a build pipeline maintained by the build service for building an output dataset based on the external dataset, the information including changes to the external dataset since a previous build of the output dataset is performed and a data schema used in the previous build, the build pipeline involving data only in one or more formats other than the specific format; incorporating the external dataset into the build pipeline without the external dataset being reformatted in accordance with requirements of the build service; receiving a request from the adaptor application module for specific information relating to a most recent data build run by the build service; providing a response to the adaptor application module.

Abstract: The present invention is directed to bispecific molecules (e.g., diabodies, bispecific antibodies, trivalent binding molecules, etc.) that possess at least one epitope-binding site that is immunospecific for an epitope of PD-1 and at least one epitope-binding site that is immunospecific for an epitope of CTLA-4 (i.e., a “PD-1×CTLA-4 bispecific molecule”). The PD-1×CTLA-4 bispecific molecules of the present invention are capable of simultaneously binding to PD-1 and to CTLA-4, particularly as such molecules are arrayed on the surfaces of human cells. The invention is directed to pharmaceutical compositions that contain such PD-1×CTLA-4 bispecific molecules, and to methods involving the use of such bispecific molecules in the treatment of cancer and other diseases and conditions. The present invention also pertains to methods of using such PD-1×CTLA-4 bispecific molecules to stimulate an immune response.

Abstract: A boom deployment mechanism is disclosed. The boom deployment mechanism may include a boom, a root plug, and a locking mechanism. In some embodiments, the boom may have a proximal end and a distal end. The boom may have a deployed configuration where the boom has a tubular shape with a slit that extends along the longitudinal length of the boom from the proximal end of the boom to the distal end of the boom. The boom may have a stowed configuration where the boom is flattened and rolled. In some embodiments, the locking mechanism may be configured to secure the proximal end of the boom to the root plug when the boom is in a deployed configuration.

Abstract: A device and method that removes moisture from human, animal, vegetable, and plant materials, yielding clear discharge water that can be returned to a sewage treatment plant. Some wastes can also yield fertilizer and an energy positive fuel source.

Abstract: A boom deployment mechanism is disclosed. The boom deployment mechanism may include a boom, a root plug, and a locking mechanism. In some embodiments, the boom may have a proximal end and a distal end. The boom may have a deployed configuration where the boom has a tubular shape with a slit that extends along the longitudinal length of the boom from the proximal end of the boom to the distal end of the boom. The boom may have a stowed configuration where the boom is flattened and rolled. In some embodiments, the locking mechanism may be configured to secure the proximal end of the boom to the root plug when the boom is in a deployed configuration.

Abstract: A device and method that removes moisture from human, animal, vegetable, and plant materials, yielding clear discharge water that can be returned to a sewage treatment plant. Some wastes can also yield fertilizer and an energy positive fuel source.

Abstract: A system and method by which an independent party serves as a representative of the shareholders or equity holders of a privately-held company for purposes of interacting with the purchaser of the privately-held company, the shareholders, governmental agencies and certain other third parties, following the closing of such merger and acquisition transaction.

Abstract: An optical switch is described having mirrors that are located over an area having an approximate oval shape. Each mirror is pivotable about a first axis and about a second axis transverse to the first axis. Because of the construction and assembly of each mirror, pivoting about the first axis is more limited than pivoting about the second axis. The area over which the mirrors are located is designed to accommodate pivoting about the first axis and about the second axis such that the area has a length and a width wherein the length is much more than the width. In addition, pivoting about the first axis limits pivoting about the second axis and pivoting about the second axis limits pivoting about the first axis. Because pivoting about one axis limits pivoting about another axis, the area over which the mirrors are located has an oval shape as opposed to a rectangular shape.

Abstract: A medication infusion system having an integrated dose rate calculation feature for selectively assigning values to a plurality of infusion parameters and automatically calculating an infusion rate from the selected parameters. One embodiment includes a stored list of drug names having associated dose rate and concentration units that are automatically set when a drug name is selected from the list. Another embodiment includes "Fast" softkeys that can be programmed to display parameter values or drug names in a predetermined sequence. The dose rate calculation feature may also be used during infusion to titrate the dosage being delivered to the patient for improved therapeutic results. The stored list of drug names and associated infusion parameters may be altered by qualified personnel using an external programming source running specialized software.

Abstract: An infusion system with an air-in-line sensor is provided with improved apparatus and method for quickly and easily clearing small quantities of undissolved gas such as air from the sensor detection field. The infusion system includes an infusion pump having control components responsive to the air-in-line sensor to activate an alarm and/or to cease pump operation when undissolved gas is detected. A "clear air" key or switch is provided on the pump for actuation by medical personnel to operate the pump in a manner delivering a small pulse of the infusion liquid to move a small detected quantity of gas past the air-in-line sensor. The system can be adapted for actuation of the "clear air" key up to a selected number of times, while monitoring and accumulating the total fluid quantity delivered to a patient.

Abstract: An infusion system with an air-in-line sensor is provided with improved apparatus and method for quickly and easily clearing small quantities of undissolved gas such as air from the sensor detection field. The infusion system includes an infusion pump having control components responsive to the air-in-line sensor to activate an alarm and/or to cease pump operation when undissolved gas is detected. A "clear air" key or switch is provided on the pump for actuation by medical personnel to operate the pump in a manner delivering a small pulse of the infusion liquid to move a small detected quantity of gas past the air-in-line sensor. The system can be adapted for actuation of the "clear air" key up to a selected number of times, while monitoring and accumulating the total fluid quantity delivered to a patient.

Abstract: An ultrasonic air-in-line detection system for use in detecting entrained air bubbles in the fluid line of a disposable cassette mounted on a main pump unit is disclosed which can accurately detect entrained air bubbles in any type of fluid, whether clear or opaque. The system uses multiple windowing and air volume number weighting to determine when a threshold count of entrained air in a predetermined number of windows of material pumped occurs, with the alarm being sounded only when this threshold count of air bubbles is present in the multiple window volume. The system of the present invention thus will detect entrained air while avoiding so-called nuisance alarms.

Abstract: An ultrasonic air-in-line detection system for use in detecting air bubbles in the fluid line of a disposable cassette mounted on a main pump unit is disclosed which can accurately detect air bubbles in any type of fluid, whether clear or opaque. The system uses a windowing technique to determine when a threshold amount of air bubbles in a predetermined volume of material pumped occurs, with the alarm being sounded only when this threshold amount of air bubbles is present in the window volume. The system of the present invention thus avoids so-called nuisance alarms due to the presence of small isolated air bubbles in the fluid due to the fluid pumped not having been degassed.

Abstract: A medication infusion system may be selectively configured to perform an emulation of any one of a plurality of Device Types corresponding to the environment of use. The particular parameters which relate to a given Device Type are set into the system either at the factory or by biomedical engineers at the hospital or other medical institution by resort to an intercoupled computer driven by appropriate software. With the system set up in this fashion, a clinical user can select a given Device Type and can view but cannot change the critical operating parameters thereof. Substantial economies and improvement of device operation are realized by the provision of one switchable system in place of the plurality of different types of devices now required in a given institution.