Abstract: The present disclosure provides compounds of Formula I or II. Compounds of Formula I or II may be used in pharmaceutical formulations, and may be used for modulating glucocorticoid receptors.

Abstract: A flight management system for providing guidance to a pilot during parabolic maneuvers including (1) an aircraft computer; (2) on-board storage; (3) a processor including instructions for receiving a target guidance parameter from the on-board storage, comparing the target guidance parameter to a value of a plurality of outputs of the aircraft computer to provide a guidance parameter having a value to a display; and (4) the display adapted to provide a visual indication to the pilot only during a maneuver execution phase wherein the visual indication is indicative of a target stick deflection based upon the value of the guidance parameter.

Abstract: Embodiments disclosed herein include semiconductor devices and methods of forming such devices. In an embodiment a semiconductor device comprises a first interlayer dielectric (ILD), a plurality of source/drain (S/D) contacts in the first ILD, a plurality of gate contacts in the first ILD, wherein the gate contacts and the S/D contacts are arranged in an alternating pattern, and wherein top surfaces of the gate contacts are below top surfaces of the S/D contacts so that a channel defined by sidewall surfaces of the first ILD is positioned over each of the gate contacts, mask layer partially filling a first channel over a first gate contact, and a fill metal filling a second channel over a second gate contact that is adjacent to the first gate contact.

Abstract: The present disclosure is generally directed to the use of compositions that include antibodies, e.g., monoclonal, chimeric, affinity-matured or humanized antibodies, antibody fragments, etc., that specifically bind one or more epitopes within a Sortilin protein, e.g., human Sortilin or mammalian Sortilin, and have improved and/or enhanced functional characteristics, in treating and/or delaying progression of a disease or injury in an individual in need thereof.

Abstract: Disclosed is a platform that manages worker users in a temporary staffing environment via an artificial machine learning model. The temporary staffing platform matches available workers to available shifts/gigs. Additional features include generating provisional or near-miss matches and informing workers how to turn those near-misses into full matches, plotting a gig-career path to develop additional skills, gamify development, and automatically generate resumes. The platform generates a set of skill tags associated with each shift/gig performed by the user. Designing of resume text files by the artificial machine learning model includes procedurally generated descriptions of experience the user has based on the recording of each shift/gig performed by the user and the skill tags associated with each recorded shift/gig, wherein a format of the resume text file is formulated by the artificial machine learning model evaluating a mix of skill tags and employers amassed by the user.

Abstract: An electrical bus system has an integrated trunk bus that includes at least one positive bus line, an equal number of negative bus line, and a messenger cable that that are twisted together to form a single, integrated trunk bus line. The messenger cable provides mechanical support and is coupled to vertical support using brackets, ground clamps, or other suitable coupling techniques, thereby eliminating the need for cable hangers or trenching. The messenger cable provides a grounding function, thereby eliminating the need for an additional grounding line. Multi-tap shear bolt connectors are used to connect the integrated trunk bus line to photovoltaic wires carrying the output from one or more solar panel arrays, thereby obviating the need for combiner boxes used in conventional systems.

Abstract: A hearing assistance system is disclosed that comprises a hearing assistance device configured to reproduce sounds and to assist a person to hear the sounds, the hearing assistance device including a left hearing assistance device and a right hearing assistance device, and a computing device in communication with the hearing assistance device. The computing device interacts with the hearing assistance device to implement a fitting mode wherein the hearing assistance device is caused to generate fitting sounds usable to evaluate whether the left and right hearing devices are properly fitted into respective left and right ears of the person. The computing device produces a communication indicative of whether the left and right hearing assistance devices are properly fitted into respective left and right ears of the person.

Abstract: The present technology provides solutions for determining transaction insights regarding a subject entity and on behalf of an inquiring entity. An exemplary method includes receiving an Application Programming Interface (API) communication calling an API, determining that the inquiring entity is permitted to access the transaction insights for the use case associated with the API, collecting data for the parameters in the defined in the API communication to yield collected data, analyzing the collected data to derive the transaction insights including at least one risk insight score and at least one reason code associated with the risk insight score, and providing a data pack of the transaction insights in a responsive communication to the inquiring entity.

Abstract: Customized updates are generated for instances of storage management software running on storage management servers in different storage systems. The filenames of class files used by each instance of the storage management software are stored in respective databases associated with those storage management software instances. Thread dumps are created and searched for class files of the storage management software to create a baseline. The baseline is updated by comparing class files used in response to UI actions and REST API calls and storing names of class files that are not already in the database. To update an instance of the storage management software, the class files of a general update are compared with the filenames in the database associated with the instance and non-matching files are omitted from the customized update foe that instance.

Abstract: Provided is a compound of formula I, or pharmaceutically acceptable salt or solvate thereof, as defined herein for use in the treatment or prevention of a Dirofilaria infection in a mammal, The compounds are also for use in the treatment or prevention of diseases or conditions caused by a Dirofilaria infection in a mammal. Also described are corresponding methods of treating or preventing a Dirofilaria infection in a mammal.

Abstract: The present disclosure is generally directed to the use of antibodies that specifically bind one or more epitopes within a sortilin protein, e.g., human sortilin or mammalian sortilin, for treating and/or delaying progression of a disease, disorder, or injury in an individual in need thereof.

Abstract: The present disclosure provides compounds of Formula I or II. Compounds of Formula I or II may be used in pharmaceutical formulations, and may be used for modulating glucocorticoid receptors.

Abstract: A tuning fork sensor system places a controlled bias on the proof-mass drive-axis electrodes to cancel the quadrature charge. Also, its charge amplifiers employ a field-effect transistor biased slightly into the triode region so that it behaves as a very large value resistor. In addition, it uses a phase-locked loop having a special loop filter in order to optimize performance by rejecting off-frequency drive feedthrough to the motor pick-off while resulting in very low phase wander for the demodulation references.

Abstract: The present disclosure provides compounds of Formula I or II. Compounds of Formula I or II may be used in pharmaceutical formulations, and may be used for modulating glucocorticoid receptors.

Abstract: A tuning fork sensor system places a controlled bias on the proof-mass drive-axis electrodes to cancel the quadrature charge. Also, its charge amplifiers employ a field-effect transistor biased slightly into the triode region so that it behaves as a very large value resistor. In addition, it uses a phase-locked loop having a special loop filter in order to optimize performance by rejecting off-frequency drive feedthrough to the motor pick-off while resulting in very low phase wander for the demodulation references.

Abstract: A method is described which provides patient vital sign measurements to a medical professional during a telemedicine visit. The method includes establishing, by a patient communication device, a video call with a medical professional communication device, processing at least one of a patient video feed from a camera of the patient communication device or an embedded sensor of the patient communication device, determining one or more patient vital sign measurements based on at least one of the processed patient video feed or signal; and transmitting, the one or more patient vital sign measurements and the patient video feed to the medical professional communication device, receipt of the one or more vital sign measurements causing the medical professional communication device to display the one or more vital sign measurements concurrently with the patient video feed.

Abstract: An improved computer system and method for the publication of business content using a metadata framework that provides for rapid development, encapsulated and extensible functionality, and simplified communication with a wide variety of systems, each of which may support multiple data formats. The system includes an interface and formatting engine configured for identifying data related to a service in data fields in a service request and a control engine for selecting and executing at least one executable code module based on the service request and generating a user interface for display at a client system. The user interface includes a financial transaction field, an amount-of-transaction field, a payee field, a payor field, and a date field.

Abstract: Aspects are generally directed to a compact and low-noise electric field detector, methods of operation, and methods of production thereof. In one example, an electric field detector includes a proof mass, a source of concentrated charge coupled to the proof mass, and a substrate having a substrate offset space defined therein, the proof mass being suspended above the substrate offset space. The electric field detector further includes a sense electrode disposed on the substrate within the substrate offset space and proximate the proof mass, the sense electrode being configured to measure a change in capacitance relative to the proof mass from movement of the proof mass in response to a received electric field at the source of concentrated charge. The electric field detector includes a control circuit coupled to the sense electrode and configured to determine a characteristic of the electric field based on the measured change in capacitance.

Abstract: Aspects are generally directed to a compact and low-noise electric field detector, methods of operation, and methods of production thereof. In one example, an electric field detector includes a proof mass, a source of concentrated charge coupled to the proof mass, and a substrate having a substrate offset space defined therein, the proof mass being suspended above the substrate offset space. The electric field detector further includes a sense electrode disposed on the substrate within the substrate offset space and proximate the proof mass, the sense electrode being configured to measure a change in capacitance relative to the proof mass from movement of the proof mass in response to a received electric field at the source of concentrated charge. The electric field detector includes a control circuit coupled to the sense electrode and configured to determine a characteristic of the electric field based on the measured change in capacitance.

Abstract: Aspects are generally directed to a compact and low-noise electric field detector, methods of operation, and methods of production thereof. In one example, an electric field detector includes a proof mass, a source of concentrated charge coupled to the proof mass, and a substrate having a substrate offset space defined therein, the proof mass being suspended above the substrate offset space. The electric field detector further includes a sense electrode disposed on the substrate within the substrate offset space and proximate the proof mass, the sense electrode being configured to measure a change in capacitance relative to the proof mass from movement of the proof mass in response to a received electric field at the source of concentrated charge. The electric field detector includes a control circuit coupled to the sense electrode and configured to determine a characteristic of the electric field based on the measured change in capacitance.