Abstract: A terminally sterilizable container includes a polypropylene bottle having a body with a manually squeezable sidewall and a thickness preventing water loss. The bottle body includes shoulders for providing autoclave produced pressure distribution and deformation resistance along with an elongated tips outfitted to a neck of the body and having a lumen therethrough with a drop dispensing orifice. A cap enclosed the elongated tip and includes enclosed with a nub for sealing the orifice to prevent autoclave produced pressure leaks.

Abstract: A container system includes a squeeze bottle of a specific volume having a neck with an open end and a medicament disposed within the bottle. A tip is provided which is insertable into the open end of the squeezable bottle and includes an internal tapered nozzle with the nozzle having increased diameter toward a tip opening. A cap is provided for removable attachment to the bottleneck for sealing the tip opening and a shoulder formed in the bottle proximate the neck and disposed at an angle is provided in order to enhance bubbless flow of the medicament to the nozzle and facilitate tamper proof sealing of the cap.

Abstract: A dispensing tip includes a body suitable for attachment to a dispensing bottle along with a nozzle having a lumen therethrough for flow of liquid formulation and an egress orifice which is in fluid communication with the lumen for the formation of droplets. A concave arcuate surface of revolution about the egress orifice is provided and depending therefrom for enhancing droplet separation from the egress orifice which in turn insures uniform droplet formation and dispensement.

Abstract: A closure for a dropper bottle includes a nozzle having a neck and a shoulder. The neck includes an aperture at an end thereof for dropwise dispensing of a liquid, and the shoulder includes an outstanding circumferential ring and threads disposed between the ring and the neck. A cap is provided with a top and an axially downwardly extending skirt. The top has a seat for sealably engaging the aperture, and the skirt has internal grooves for engaging the nozzle threads and an internal circumferential lip for sealably engaging the ring. The lip is spaced apart from the aperture for enabling simultaneous sealing of the aperture and the ring upon rotation of said cap onto said nozzle.