Abstract: The present disclosure provides T cell receptor (TCR) fusion proteins comprising a TCR that binds to a GVYDGREHTV (SEQ ID NO:34) HLA-A*02 complex that is covalently linked to a T cell engaging domain that binds a protein expressed on a cell surface of a T cell and an antibody Fc domain, as well as polynucleotides, vectors, kits, host cells, pharmaceutical compositions, methods, and uses related thereto.

Abstract: The present disclosure provides T cell receptor (TCR) fusion proteins comprising a TCR that binds to a GVYDGREHTV (SEQ ID NO:34) HLA-A*02 complex that is covalently linked to a T cell engaging domain that binds a protein expressed on a cell surface of a T cell and an antibody Fc domain, as well as polynucleotides, vectors, kits, host cells, pharmaceutical compositions, methods, and uses related thereto.

Abstract: The present invention provides an antigen binding protein comprising an antigen binding domain that binds to plasmin, wherein the antigen binding protein reduces the activity of plasmin. The invention also provides compositions comprising the antigen binding protein, and uses and method of treatment comprising the same.

Abstract: A carbonation system for a beverage appliance or machine that can include a liquid chamber and a carbonation chamber separated from the liquid chamber by a wall of the carbonation chamber is disclosed herein. In some implementations, the liquid chamber is defined by a liquid tank (e.g., a water tank), and the carbonation chamber is defined by a carbonation tank. The carbonation system can move liquid (e.g., water) from the liquid chamber to the carbonation chamber and introduce carbonating gas (e.g., carbon dioxide) into the carbonation chamber to create a carbonated liquid (e.g., a carbon dioxide water dissolution, such as carbonated water, sparkling water, or seltzer).

Abstract: The present invention relates to antigen binding proteins comprising an antigen binding domain that binds to plasminogen, wherein the antigen binding protein reduces the activation of plasminogen to plasmin, pharmaceutical compositions comprising the same, and methods and uses thereof.

Abstract: A method and apparatus for frothing a beverage, e.g., using a beverage preparing device and an ejector is described. Within a housing of the beverage preparing device, an air supply and steam supply may be arranged to deliver air and steam to an ejector outside of the housing. Beverage liquid may be frothed by providing steam and air, then steam alone to achieve frothing and heating. An ejector may supply a mixture of steam and air and a controller may be used to regulate the flow of steam and air through the ejector. The ejector may have a venturi that uses steam flow to create a low pressure region, which draws air into the ejector.

Abstract: The present invention relates to methods of producing recombinant plasminogen in a mammalian expression system. A method for producing plasminogen, the method comprising (i) providing a host cell comprising a first recombinant polynucleotide encoding plasminogen and a second recombinant polynucleotide encoding a plasminogen activation inhibitor; (ii) culturing said host cell in a suitable culture medium under conditions to effect expression of plasminogen from the first polynucleotide and plasminogen activation inhibitor from the second polynucleotide.

Abstract: The present invention relates to soluble multi-domain binding molecules comprising T cell receptors (TCR) having specificity for an antigen, an immunoglobulin Fc domain or an albumin-binding moiety; and an immune effector domain. Such multi-domain binding molecules are advantageous because they display improved half-life while retaining function.

Abstract: A carbonation system for a beverage appliance or machine that can include a liquid chamber and a carbonation chamber separated from the liquid chamber by a wall of the carbonation chamber is disclosed herein. In some implementations, the liquid chamber is defined by a liquid tank (e.g., a water tank), and the carbonation chamber is defined by a carbonation tank. The carbonation system can move liquid (e.g., water) from the liquid chamber to the carbonation chamber and introduce carbonating gas (e.g., carbon dioxide) into the carbonation chamber to create a carbonated liquid (e.g., a carbon dioxide water dissolution, such as carbonated water, sparkling water, or seltzer).

Abstract: A jacketed structure includes at least one penetrator slug; a jacket surrounding the at least one penetrator slug; and a deformable sleeve surrounding a portion of the at least one penetrator slug and encased by the jacket. The deformable sleeve includes porous material, which absorbs plastic deflection of the jacket during an engraving process with a barrel of a weapon during firing. The at least one penetrator slug includes material having a hardness value greater than a hardness value of the jacket and the deformable sleeve. The deformable sleeve surrounds a rear portion of the at least one penetrator slug. The deformable sleeve surrounds approximately half of the at least one penetrator slug. The deformable sleeve is configured to deform symmetrically during firing of a weapon containing the jacketed structure.

Abstract: An electronic handheld library is disclosed that fully replaces hard copy textbooks and references, audio-visual materials, and successor instructional materials, and receives, stores, and displays other digital data in electronic form. In a single fully integrated design the handheld library meets all six of the specific requirements for a successful launch, development, and operation, specifically focusing on the real requirement; providing excellent presentation quality; possessing inherent high resistance to accidental damage; possessing inherent high theft resistance; providing protection of the source, data, user, and handheld library itself from malicious or accidental events; and providing affordability equal to or better than the objects replaced. Compared to what it replaces, it provides significant advantages for institutional financial management and for students' health.

Abstract: A stout wall assembly which self-transports under remote control or onboard machine logic is disclosed. It combines three very well understood and proven technologies into a novel, new military system for creating protected positions behind very strong cover while a formation is in motion or stationary. The wall assembly is unmanned and is designed to sacrificially block any destructive effects directed at the protected object in its lee. It provides a non-pyrotechnical, passive, always-on, solid, physical barrier defense with no reaction or recycle time whatsoever, an unlimited duty cycle, and minimal possibility of fratricide or collateral damage. It can defeat or degrade kinetic energy, blast, fragmentation, fire, particulate, shaped charge, and high explosive squash head weapons and is uniquely capable against street-level improvised explosive devices.

Abstract: A barrier which is mobile and self-propelled and is controlled by remote control or by self-generated commands created in accordance with pre-loaded or downloaded instructions is disclosed. It can be interposed between a stationary or moving protected object and a suspected threat and maintained in that alignment until updated guidance instructions are received or generated.

Abstract: An area earthquake defense system is disclosed which uses military planning principles; automated command and control systems; the technology of wave manipulation demonstrated in optical engineering, sonar, and anti-tank weapons and their countermeasures; and proven electromagnetic technology. Deeply buried, specially configured, passive devices attenuate, temporally segment, and redirect earthquake shock waves. Such a system, fully integrated into the local geological structure, can reduce the shock reaching the protected area, and, within that area, channel it away from those structures most difficult to protect with single point measures. This is especially true when the plurality of passive devices is complemented by an automated decision and command loop and dynamically reconfigurable active devices embedded at a variety of depths.

Abstract: Panel assemblies that include a core sandwiched between face sheets made from composite material. A pigmented topcoat layer is applied directly to the composite material without the need for a separate adhesive. The pigmented topcoat layer includes a thermoplastic binder resin/pigment mixture that can be cured with the composite material in a single step. The topcoat may include permanent and/or temporary substrates for carrying the binder resin/pigment mixture and for providing a surface finish to the panel assembly.

Abstract: Panel assemblies that include a core sandwiched between face sheets made from composite material. A pigmented topcoat layer is applied directly to the composite material without the need for a separate adhesive. The pigmented topcoat layer includes a thermoplastic binder resin/pigment mixture that can be cured with the composite material in a single step. The topcoat may include permanent and/or temporary substrates for carrying the binder resin/pigment mixture and for providing a surface finish to the panel assembly.