Abstract: Methods and systems for determining a risk level of a neurodegenerative disease by analyzing expression levels of a plurality of RNA transcripts of a sample. The method uses an imager, a magnet, a light source, and a flow cell that includes a functionalized surface having a plurality of capture probes. Each of the plurality of capture probes is configured to bind molecules in the sample comprising one of the plurality of RNA transcripts. The method includes the following steps. Binding molecules in the sample to a magnetic particle. Directing the molecules to the functionalized surface using the magnet. Binding each specific molecule of the molecules to one of the plurality of capture probes configured to bind the RNA transcript of the specific molecule. Directing a light beam from the light source at bound molecules bound on each of the plurality of capture probes. Capturing light from the bound molecules.

Abstract: Various embodiments provide methods for the detection, the diagnosis, and/or the prediction of disease onset of Alzheimer's disease. Methods for determining a state of Alzheimer's disease are provided. Accordingly, these methods can comprise the steps of placing a sample comprising at least one blood component onto a substrate, labeling the sample to identify at least one epigenetic marker and at least one of an inflammation marker and a cellular stress marker; determining an amount of the markers; performing a multivariate statistical analysis to produce an output value; comparing the output value to a reference value; and determining a state of Alzheimer's disease.

Abstract: Adhesives, reaction systems, and processes for the production of lignocellulosic composites. The reaction system comprises a multi-component adhesive and a lignocellulosic substrate. The lignocelluosic substrate comprises a plurality of lignocellulosic adherends and is preferably a mass of wood particles. The multi-component adhesive comprises a multi-functional isocyanate, a hydrophilic polyahl, and an organotransition metal catalyst. The multi-component adhesive is characterized by being formulated into at least two mutually reactive chemical component streams. The process comprises the separate application of the mutually reactive chemical component streams of the multi-component adhesive to the lignocellulosic substrate, followed by forming and pressing the adhesive treated substrate under conditions appropriate for curing the adhesive and forming a lignocellulosic composite article.

Abstract: Adhesives, reaction systems, and processes for the production of lignocellulosic composites. The reaction system comprises a multi-component adhesive and a lignocellulosic substrate. The lignocellulosic substrate comprises a plurality of lignocellulosic adherends and is preferably a mass of wood particles. The multi-component adhesive comprises a multi-functional isocyanate, a hydrophilic polyahl, and an organotransition metal catalyst. The multi-component adhesive is characterized by being formulated into at least two mutually reactive chemical component streams. The process comprises the separate application of the mutually reactive chemical component streams of the multi-component adhesive to the lignocellulosic substrate, followed by forming and pressing the adhesive treated substrate under conditions appropriate for curing the adhesive and forming a lignocellulosic composite article.

Abstract: Various embodiments provide methods for the detection, the diagnosis, and/or the progression monitoring of Alzheimer's disease by observing the epigenetic markers in leukocytes. Methods for determining a state of Alzheimer's disease are provided. Accordingly, these methods can comprise the steps of placing a sample comprising at least one blood component onto a substrate labeling the sample to identify at least one epigenetic marker; determining an amount of the at least one epigenetic marker; comparing the amount to a reference value; and determining a state of Alzheimer's disease.

Abstract: Various embodiments provide methods for the detection, the diagnosis, and/or the prediction of disease onset of Alzheimer's disease. Methods for determining a state of Alzheimer's disease are provided. Accordingly, these methods can comprise the steps of placing a sample comprising at least one blood component onto a substrate, labeling the sample to identify at least one epigenetic marker and at least one of an inflammation marker and a cellular stress marker; determining an amount of the markers; performing a multivariate statistical analysis to produce an output value; comparing the output value to a reference value; and determining a state of Alzheimer's disease.

Abstract: Various embodiments provide methods for the detection, the diagnosis, and/or the progression monitoring of Alzheimer's disease by observing the epigenetic markers in leukocytes. Methods for determining a state of Alzheimer's disease are provided. Accordingly, these methods can comprise the steps of placing a sample comprising at least one blood component onto a substrate labeling the sample to identify at least one epigenetic marker; determining an amount of the at least one epigenetic marker; comparing the amount to a reference value; and determining a state of Alzheimer's disease.

Abstract: Various embodiments provide methods for the detection, the diagnosis, and/or the prediction of disease onset of Alzheimer's disease. Methods for determining a state of Alzheimer's disease are provided. Accordingly, these methods can comprise the steps of placing a sample comprising at least one blood component onto a substrate, labeling the sample to identify at least one epigenetic marker and at least one of an inflammation marker and a cellular stress marker; determining an amount of the markers; performing a multivariate statistical analysis to produce an output value; comparing the output value to a reference value; and determining a state of Alzheimer's disease.

Abstract: Various embodiments provide methods for the detection, the diagnosis, and/or the progression monitoring of Alzheimer's disease by observing the epigenetic markers in leukocytes. Methods for determining a state of Alzheimer's disease are provided. Accordingly, these methods can comprise the steps of placing a sample comprising at least one blood component onto a substrate labeling the sample to identify at least one epigenetic marker; determining an amount of the at least one epigenetic marker; comparing the amount to a reference value; and determining a state of Alzheimer's disease.

Abstract: Adhesives, reaction systems, and processes for the production of lignocellulosic composites. The reaction system comprises a multi-component adhesive and a lignocellulosic substrate. The lignocelluosic substrate comprises a plurality of lignocellulosic adherends and is preferably a mass of wood particles. The multi-component adhesive comprises a multi-functional isocyanate, a hydrophilic polyahl, and an organotransition metal catalyst. The multi-component adhesive is characterized by being formulated into at least two mutually reactive chemical component streams. The process comprises the separate application of the mutually reactive chemical component streams of the multi-component adhesive to the lignocellulosic substrate, followed by forming and pressing the adhesive treated substrate under conditions appropriate for curing the adhesive and forming a lignocellulosic composite article.

Abstract: The present invention provides methods for profiling mRNA production in single cells, in particular, during disease stages. The invention also provides a method for monitoring gene expression in a single cell which has been isolated from tissue. The methods of the present invention may be used to diagnose or monitor the progression of disease.

Abstract: A process is disclosed for strengthening and sizing paper which comprises the step of applying a composition comprising (a) an isocyanate and (b) an isocyanate-reactive component comprising at least one polyol having an ethylene oxide content of at least 1%, wherein said composition does not contain water to the paper by means of an electrostatic spraying device having a linear orifice.