Patents by Inventor Paul Dabrowski
Paul Dabrowski has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230051840Abstract: Disclosed herein are cartridges for transfecting cells and/or generating clonal populations of cells comprising: a) a first compartment configured for performing cell transfection, wherein the first compartment comprises a first inlet configured for introduction of a cell sample; b) a second compartment configured for performing cell selection, wherein an inlet of the second compartment is operably coupled to an outlet of the first compartment, and wherein the second compartment further comprises at least one optically-transparent wall and an outlet that is operably coupled to an intermediate cell removal port; and c) a third compartment configured for performing cell expansion, wherein an inlet of the third compartment is operably coupled to the outlet of the second compartment.Type: ApplicationFiled: January 20, 2021Publication date: February 16, 2023Inventors: Reed Kelso, Paul Dabrowski, Ivan Razinkov, Alexander Brown, Brandon Whitney, Maryam Khosroshahi
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Publication number: 20230031222Abstract: A system for processing cells is provided. The system can include a cell culture container, a fluid handling device, and one or more removable cell processing modules for performing one or more cell processing processes. The one or more removable cell processing modules can include a fluid handling pathway. The one or more removable cell processing modules can be fluidly connected to the cell culture container and the fluid handling device via a receptacle in which the cell processing modules may be inserted. The system can be a closed system.Type: ApplicationFiled: September 23, 2022Publication date: February 2, 2023Inventors: Myo Thu MAUNG, Matthew Everly FOWLER, Paul DABROWSKI, Sergey SHKAPOV, Ivan RAZINKOV, Jingling LI, Daniel SLOMSKI, Jeffrey SMITH, James Duncan BRAZA, Aliya KUSUMO, Brandon Phillip WHITNEY
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Publication number: 20220314188Abstract: The present invention provides an automated modular system and method for production of biopolymers including DNA and RNA. The system and method automates the complete production process for biopolymers. Modular equipment is provided for performing production steps with the individual modules arrange in a linear array. Each module includes a control system and can be rack mounted. One side of the array of modules provides connections for power, gas, vacuum and reagents and is accessible to technicians. On the other side of the array of modules a robotic transport system is provided for transporting materials between module interfaces. The elimination of the requirement for human intervention at multiple steps in the production process significantly decreases the costs of biopolymer production and reduces unnecessary complexity and sources of quality variation.Type: ApplicationFiled: June 24, 2022Publication date: October 6, 2022Inventors: Paul Dabrowski, Michael Dabrowski, Fabian Gerlinghaus, Alex Pesch
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Patent number: 11439971Abstract: The present invention provides an automated modular system and method for production of biopolymers including DNA and RNA. The system and method automates the complete production process for biopolymers. Modular equipment is provided for performing production steps with the individual modules arrange in a linear array. Each module includes a control system and can be rack mounted. One side of the array of modules provides connections for power, gas, vacuum and reagents and is accessible to technicians. On the other side of the array of modules a robotic transport system is provided for transporting materials between module interfaces. The elimination of the requirement for human intervention at multiple steps in the production process significantly decreases the costs of biopolymer production and reduces unnecessary complexity and sources of quality variation.Type: GrantFiled: September 15, 2020Date of Patent: September 13, 2022Assignee: Synthego CorporationInventors: Paul Dabrowski, Michael Dabrowski, Fabian Gerlinghaus, Alex Pesch
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Publication number: 20210047668Abstract: The present invention provides improved automated systems and methods for synthesis of biopolymers including DNA and RNA. The automated systems and methods represent a number of improvements over existing systems for multiplex synthesis of biopolymers in a combinatorial fashion.Type: ApplicationFiled: August 10, 2020Publication date: February 18, 2021Inventors: Paul Dabrowski, Fabian Gerlinghaus, Reed Kelso, John Andrew Walker, II
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Publication number: 20200406221Abstract: The present invention provides an automated modular system and method for production of biopolymers including DNA and RNA. The system and method automates the complete production process for biopolymers. Modular equipment is provided for performing production steps with the individual modules arrange in a linear array. Each module includes a control system and can be rack mounted. One side of the array of modules provides connections for power, gas, vacuum and reagents and is accessible to technicians. On the other side of the array of modules a robotic transport system is provided for transporting materials between module interfaces. The elimination of the requirement for human intervention at multiple steps in the production process significantly decreases the costs of biopolymer production and reduces unnecessary complexity and sources of quality variation.Type: ApplicationFiled: September 15, 2020Publication date: December 31, 2020Inventors: Paul Dabrowski, Michael Dabrowski, Fabian Gerlinghaus, Alex Pesch
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Patent number: 10814300Abstract: The present invention provides an automated modular system and method for production of biopolymers including DNA and RNA. The system and method automates the complete production process for biopolymers. Modular equipment is provided for performing production steps with the individual modules arrange in a linear array. Each module includes a control system and can be rack mounted. One side of the array of modules provides connections for power, gas, vacuum and reagents and is accessible to technicians. On the other side of the array of modules a robotic transport system is provided for transporting materials between module interfaces. The elimination of the requirement for human intervention at multiple steps in the production process significantly decreases the costs of biopolymer production and reduces unnecessary complexity and sources of quality variation.Type: GrantFiled: January 17, 2020Date of Patent: October 27, 2020Assignee: Synthego CorporationInventors: Paul Dabrowski, Michael Dabrowski, Fabian Gerlinghaus, Alex Pesch
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Publication number: 20200147578Abstract: The present invention provides an automated modular system and method for production of biopolymers including DNA and RNA. The system and method automates the complete production process for biopolymers. Modular equipment is provided for performing production steps with the individual modules arrange in a linear array. Each module includes a control system and can be rack mounted. One side of the array of modules provides connections for power, gas, vacuum and reagents and is accessible to technicians. On the other side of the array of modules a robotic transport system is provided for transporting materials between module interfaces. The elimination of the requirement for human intervention at multiple steps in the production process significantly decreases the costs of biopolymer production and reduces unnecessary complexity and sources of quality variation.Type: ApplicationFiled: January 17, 2020Publication date: May 14, 2020Inventors: Paul Dabrowski, Michael Dabrowski, Fabian Gerlinghaus, Alex Pesch
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Patent number: 10569249Abstract: The present invention provides an automated modular system and method for production of biopolymers including DNA and RNA. The system and method automates the complete production process for biopolymers. Modular equipment is provided for performing production steps with the individual modules arrange in a linear array. Each module includes a control system and can be rack mounted. One side of the array of modules provides connections for power, gas, vacuum and reagents and is accessible to technicians. On the other side of the array of modules a robotic transport system is provided for transporting materials between module interfaces. The elimination of the requirement for human intervention at multiple steps in the production process significantly decreases the costs of biopolymer production and reduces unnecessary complexity and sources of quality variation.Type: GrantFiled: July 5, 2018Date of Patent: February 25, 2020Assignee: Synthego CorporationInventors: Paul Dabrowski, Michael Dabrowski, Fabian Gerlinghaus, Alex Pesch
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Publication number: 20190076814Abstract: The present invention provides improved automated systems and methods for synthesis of biopolymers including DNA and RNA. The automated systems and methods represent a number of improvements over existing systems for multiplex synthesis of biopolymers in a combinatorial fashion.Type: ApplicationFiled: September 13, 2018Publication date: March 14, 2019Inventors: Paul Dabrowski, Fabian Gerlinghaus, Reed Kelso, John Andrew Walker, II
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Publication number: 20180311637Abstract: The present invention provides an automated modular system and method for production of biopolymers including DNA and RNA. The system and method automates the complete production process for biopolymers. Modular equipment is provided for performing production steps with the individual modules arrange in a linear array. Each module includes a control system and can be rack mounted. One side of the array of modules provides connections for power, gas, vacuum and reagents and is accessible to technicians. On the other side of the array of modules a robotic transport system is provided for transporting materials between module interfaces. The elimination of the requirement for human intervention at multiple steps in the production process significantly decreases the costs of biopolymer production and reduces unnecessary complexity and sources of quality variation.Type: ApplicationFiled: July 5, 2018Publication date: November 1, 2018Inventors: Paul Dabrowski, Michael Dabrowski, Fabian Gerlinghaus, Alex Pesch
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Patent number: 10040048Abstract: The present invention provides an automated modular system and method for production of biopolymers including DNA and RNA. The system and method automates the complete production process for biopolymers. Modular equipment is provided for performing production steps with the individual modules arrange in a linear array. Each module includes a control system and can be rack mounted. One side of the array of modules provides connections for power, gas, vacuum and reagents and is accessible to technicians. On the other side of the array of modules a robotic transport system is provided for transporting materials between module interfaces. The elimination of the requirement for human intervention at multiple steps in the production process significantly decreases the costs of biopolymer production and reduces unnecessary complexity and sources of quality variation.Type: GrantFiled: September 25, 2015Date of Patent: August 7, 2018Assignee: SYNTHEGO CORPORATIONInventors: Paul Dabrowski, Michael Dabrowski, Fabian Gerlinghaus, Alex Pesch