Patents by Inventor Paul David Toman

Paul David Toman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Production of collagen in the milk of transgenic mammals
    Publication number: 20100305039
    Abstract: The invention provides transgenic nonhuman mammals capable secreting exogenous procollagen or collagen into their milk. The mammals are healthy and capable of producing procollagen or collagen at high levels, usually in trimeric form. Suitable transgenes for incorporation into the mammals are also provided.
    Type: Application
    Filed: November 10, 2008
    Publication date: December 2, 2010
    Applicants: Pharming Intellectual Property B.V., Cohesion Technologies, Inc.
    Inventors: Costas N. Karatzas, Frank Pieper, Ineke De Wit, Richard Berg, Gerard Platenburg, Paul David Toman
  • Production of collagen in the milk of transgenic mammals
    Patent number: 6713662
    Abstract: The invention provides transgenic nonhuman mammals capable secreting exogenous procollagen or collagen into their milk. The mammals are healthy and capable of producing procollagen or collagen at high levels, usually in trimeric form. Suitable transgenes for incorporation into the mammals are also provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: March 30, 2004
    Assignees: Pharming Intellectual Property B.V., Cohesion Technologies
    Inventors: Costas N. Karatzas, Frank Pieper, Ineke De Wit, Richard Berg, Gerard Platenburg, Paul David Toman
  • Mutated recombinant collagens
    Patent number: 6653450
    Abstract: The invention provides recombinant procollagen chains having a natural collagen chain separated from one or two propeptides by one or two non-natural site-specific proteolytic agent (e.g., protease) recognition sites. A wide variety of propeptides and site-specific proteolytic agent recognition sites may be used: the selection of particular site-specific proteolytic agent/recognition site pairs is based on the conformation of the resulting procollagen, the availability of the site-specific proteolytic agent, the compatibility of the proteolysis with production of mature collagen, among other factors. Recombinant collagens chains are produced by contacting the subject recombinant procollagen chains with the appropriate site-specific proteolytic agents. Nucleic acids encoding the subject procollagen chains operably linked to transcription regulatory elements are used in vectors and cells for the production of recombinant collagen.
    Type: Grant
    Filed: July 22, 1994
    Date of Patent: November 25, 2003
    Assignee: Cohesion Technologies, Inc.
    Inventors: Richard A. Berg, Paul David Toman, Donald G. Wallace