Abstract: The invention relates to compounds of the structure of formula I and II: where X is selected from the group consisting of O, S and NH; Y, A and B are independently selected from the group consisting of N and CH; D, E and F are independently selected from the group consisting of CH, N, O and S; the symbol ---- represents a single or a double bond; and R1, R2 and R3 are independently selected from the group consisting of H, electron withdrawing groups and electron releasing groups. In other embodiments, the compounds are used as oxygen scavengers and in barrier compositions and articles.

Abstract: Disclosed herein are therapeutic methods of administering compounds that modulate the C—C chemokine receptor type 4 (CCR4) for the treatment of Epstein Bar virus (EBV) positive cancers and malignancies.

Abstract: An integrated circuit package and method of fabrication are described. The integrated circuit package includes a lead frame having a first surface and a second opposing surface and a semiconductor die having a first, active surface in which circuitry is disposed and a second opposing surface attached to the first surface of the lead frame. A magnet attached to the second surface of the lead frame has a non-contiguous central region and at least one channel extending laterally from the central region. An overmold material forms an enclosure surrounding the magnet, semiconductor die, and a portion of the lead frame.

Abstract: Examples relate to digital context aware (DCA) data collection. In some examples, a DCA start location component is positioned at a first location along a travel route, and a DCA end location component is positioned at a second location along the travel route. In response to using a wireless interface to detect the DCA start location component, data collection of measurements by a sensor are initiated. In response to using the wireless interface to detect the DCA end location component, the data collection by the sensor is halted.

Abstract: Apparatus for delivering therapeutic agents to the central nervous system of a subject is described. The apparatus includes at least one intracranial catheter and a percutaneous access device. The percutaneous access device includes a body having at least one extracorporeal surface and at least one subcutaneous surface, the body defining at least one port for connection to an implanted intracranial catheter. The port is accessible from the extracorporeal surface of the device, but is provided with a seal such as a rubber bung between the lumen of the port and the extracorporeal surface. The percutaneous access device may have more than two ports and/or a flange. A method of implanting the percutaneous access device is also described.

Abstract: In an embodiment, a method includes: adjusting a first flight control device of a rotorcraft to control flight around a first axis of the rotorcraft, the first flight control device exercising flight control authority around the first axis of the rotorcraft; detecting a failure of the first flight control device; transitioning at least a portion of the flight control authority around the first axis of the rotorcraft from the first flight control device to a second flight control device of the rotorcraft, the transitioning being performed automatically in response to detecting the failure of the first flight control device; and adjusting the second flight control device to control flight around the first axis of the rotorcraft, the second flight control device being adjusted by a first control process when the rotorcraft is in a first flight mode, the second flight control device being adjusted by a second control process when the rotorcraft is in a second flight mode.

Abstract: A computing system retrieves ball-by-ball data for a plurality of sporting events. The computing system generates a trained neural network based on ball-by-ball data supplemented with ball-by-ball data with ball-by-ball match context features and personalized embeddings based on a batsman and a bowler for each delivery. The computing system receives a target batsman and a target bowler for a pitch to be delivered in a target event. The computing system identifies target ball-by-ball data for a window of pitches preceding the to be delivered pitch. The computing system retrieves historical ball-by-ball data for each of the target batsman and the target bowler. The computing system generates personalized embeddings for both the target batsman and the target bowler based on the historical ball-by-ball data. The computing system predicts a shot type for the pitch to be delivered based on the target ball-by-ball data and the personalized embeddings.

Abstract: A method and associated system for matching and delivering digital work metadata to one or more digital service providers including modifying one or more digital work metadata files, which includes removing non-critical data or segment-erroneous data or performing a language translation; reformatting the one or more digital work metadata files for compatibility with a transformer model-based AI matching operation; performing a block grouping operation on the one or more digital work metadata files, where data associated with the one or more digital work metadata files is grouped in blocks and analyzed for one or more pairs of data records; performing the transformer model-based AI matching operation to determine whether each pair of the one or more pairs of data records comprise a matching pair of data records; and transmitting output data from the transformer model-based artificial intelligence matching operation to the one or more digital service providers.

Abstract: A method for demodulating an RF signal to polar in-phase and quadrature (IQ) components that includes converting an RF signal with an analog-to-digital converter and calculating the polar in-phase and quadrature (IQ) components of the RF signal as an IQ phasor phase angle and an IQ amplitude using a digital processor. The analog-to-digital converter uses a sampling rate, where, when the sampling rate used has sampling rates other than 3 times an RF carrier frequency of the RF signal, a digital logic circuit splines data to the sampling rate of 3 times the RF carrier frequency of the RF signal. The digital processor calculates the polar in-phase and quadrature (IQ) components of the RF signal as an IQ phasor phase angle and an IQ amplitude using addition, subtraction, multiplication, division, and absolute value.

Abstract: A system allows the identification and protection of sensitive data in a multiple ways, which can be combined for different workflows, data situations or use cases. The system scans datasets to identify sensitive data or identifying datasets, and to enable the anonymisation of sensitive or identifying datasets by processing that data to produce a safe copy. Furthermore, the system prevents access to a raw dataset. The system enables privacy preserving aggregate queries and computations. The system uses differentially private algorithms to reduce or prevent the risk of identification or disclosure of sensitive information. The system scales to big data and is implemented in a way that supports parallel execution on a distributed compute cluster.

Abstract: Provided are antibodies that target the cellular efflux pump ABCG2. Also provided are pharmaceutical compositions, nucleic acids, recombinant expression vectors, cells, and kits that include or encode such antibodies. Methods of using the antibodies for detecting presence or absence of ABCG2 expression in cells, e.g., tumor cells, level of ABCG2 expression, and/or inhibiting ABCG2 function are also disclosed. In addition, multi-specific antibodies that bind to ABCG2 and a polypeptide expressed on surface of a cancer cell are provided. The polypeptide may be the efflux pump MDR1 or a cancer-associated antigen. Also provided are methods for treating a subject for a cancer that include administering to the subject an anti-ABCG2 antibody as disclosed herein or a multi-specific antibody that targets both ABCG2 and a cancer-associated antigen or MDR1.

Abstract: The present invention provides a method and apparatus for reducing condensation in a respiratory circuit during a delivery of humidifying agent into the respiratory circuit. A first amount of humidification agent to a first volume of gas is delivered to a patient respiratory circuit during a patient inhalation cycle or immediately after a patient exhalation cycle, and the humidification agent or the first volume of gas is heated. Condensation is removed from the respiratory circuit at least in part by providing, during a patient exhalation cycle or immediately after a patient inhalation cycle, a second amount of the humidification agent to a second volume of gas being delivered from the gas source to the patient respiratory circuit, the second amount of the humidification agent being significantly less than the first amount of the humidification agent.

Abstract: A gas-liquid contacting apparatus and method are described, in which at least one rotor assembly including packing is arranged in a contacting chamber containing at least one stator assembly including at least one heat exchanger arranged to thermally modulate the gas-liquid contacting so that each stator assembly is operatively arranged with each stator assembly to provide gas-liquid contacting at temperatures effective for mass exchange between the gas and liquid. The rotor and stator assemblies may be of annular shape, or may be of disk shape in a stacked array of rotor assemblies alternating with stator assemblies. Such apparatus and method are usefully employed for CO2 capture from CO2-containing flue gases such as combustion effluents from power generation plants.

Abstract: Provided are antibodies that target the cellular efflux pump MDR1. Also provided are pharmaceutical compositions, nucleic acids, recombinant expression vectors, cells, and kits that include or encode such antibodies. Methods of using the antibodies for detecting presence or absence of MDR1 expression in cells, e.g., tumor cells, level of MDR1 expression, and/or inhibiting MDR1 function are also disclosed. In addition, multi-specific antibodies that bind to MDR1 and a tumor associated antigen are provided. Also provided are methods for treating a subject for a cancer that include administering to the subject an anti-MDR1 antibody as disclosed herein or a multi-specific antibody that targets both MDR1 and a tumorassociated antigen.

Abstract: A cleaning device including a spray bottle, roller, and scrubber apparatus. The roller is positioned about the reservoir of the spray bottle. The removable scrubber is positioned in the base of the spray bottle. The roller uses a washable absorbent pad to clean surfaces with cleaning solution deposited by the spray bottle. The spray mechanism is held in two grips, a spray grip and a reverse grip in order to make use of the spray mechanism and the roller, respectively.

Abstract: Methods and apparatus that can include a rotatable target to generate a sinusoidal signal in a magnetic field sensor, wherein the target includes a plurality of sinusoidal teeth to reduce angular error. A magnetic field sensor can be configured to determine a position of the target. In embodiments, a rotatable target to generate a sinusoidal signal in a magnetic field sensor can include a plurality of sinusoidal teeth and a number of harmonics to reduce angular error.

Abstract: Provided are multi-specific antibodies that target both the cellular efflux pump ABCG2 and a cancer-associated antigen as well as pharmaceutical compositions, nucleic acids, recombinant expression vectors, cells, and kits that include or encode such multi-specific antibodies. Methods of treating a subject for a cancer that include administering to the subject a multi-specific antibody that targets both a cellular efflux pump and a cancer-associated antigen are also provided. Provided as well are methods of generating the described multi-specific antibodies and reagents related thereto, including genetically modified cell lines useful in the subject methods and methods of making such genetically modified cell lines.

Abstract: A method of generating a player prediction is disclosed herein. A computing system retrieves data from a data store. The computing system generates a predictive model using an artificial neural network. The artificial neural network generates one or more personalized embeddings that include player-specific information based on historical performance. The computing system selects, from the data, one or more features related to each shot attempt captured in the data. The artificial neural network learns an outcome of each shot attempt based at least on the one or more personalized embeddings and the one or more features related to each shot attempt.

Abstract: A fluid device generally comprises a staging reservoir which may receive a volume of fluid flowing from a primary reservoir via a coupler upon operation of an actuator, wherein the staging reservoir is usable to measure fluid within the device in order to dispense a desired amount of fluid.

Abstract: An apparatus is provided for nanoantenna-enhanced detection of infrared radiation. The apparatus includes one or more detector pixels. A plurality of detector pixels can constitute a focal plane array (FPA). Each detector pixel carries at least a first and a second subpattern of nanoantenna elements, with elements of the second subpattern interpolated between elements of the first subpattern. Each detector pixel also includes separate collection electrodes for collecting photogenerated current from the respective subpatterns.