Patents by Inventor Paul Donders
Paul Donders has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230326728Abstract: The effective quantum efficiency of a metal-channel photomultiplier tube can be increased with an optical system. The optical system can direct incident light from areas of low efficiency on the cathode of the metal-channel photomultiplier tube instead to areas of high efficiency on the cathode. These high-efficiency areas of the cathode can correspond to a position between the dynode structure.Type: ApplicationFiled: July 25, 2022Publication date: October 12, 2023Inventors: Paul Donders, Derek Mackay
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Patent number: 9941103Abstract: A bias-variant photomultiplier tube (PMT) includes a photocathode that when operating absorbs photons and emits photoelectrons responsive to the absorbed photons. The bias-variant PMTO also includes a plurality of dynodes that receive the photoelectrons emitted by the photocathode. The plurality of dynodes include a first pair of dynodes having a first bias difference and at least a second pair of dynodes having a second bias difference. The second bias difference is greater than the first bias difference. The bias-variant PMTO also includes an anode to receive photoelectrons directed from the plurality of dynodes.Type: GrantFiled: October 17, 2014Date of Patent: April 10, 2018Assignee: KLA-Tencor CorporationInventors: Derek Mackay, Paul Donders, Kai Cao, Jeongsik Lim
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Patent number: 9057701Abstract: A system for performing automated cell screening in drug discovery, includes an automated microscope, a fast autofocus device, and a digital imaging system. Processes are implemented in software through which relevant cellular material is segmented and quantified with minimal user interaction. Improvements in the following areas: known methods for image processing are implemented in such a way that automated segmentation is achieved; sets of known measurements (pixel counting, etc.) are implemented as methods which demonstrate aspects of biology in a reliable fashion; components for automated positioning, focusing, imaging and processing of a multiplicity of samples are integrated as systems within which the segmentation and measurement methods may be mounted; and components and methods are adapted into systems which yield more highly automated and more rapid cell screening.Type: GrantFiled: June 17, 2010Date of Patent: June 16, 2015Assignee: GE HEALTHCARE NIAGARA INC.Inventors: Peter Ramm, Yuriy Alexandrov, Paul Donders, Carlos Zarate, Bohdan J. Soltys
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Publication number: 20150136948Abstract: A bias-variant photomultiplier tube (PMT) includes a photocathode that when operating absorbs photons and emit photoelectrons responsive to the absorbed photons. The bias-variant PMTO also includes a plurality of dynodes that receive the photoelectrons emitted by the photocathode. The plurality of dynodes include a first pair of dynodes having a first bias difference and at least a second pair of dynodes having a second bias. The second bias difference is greater than the first bias difference. The bias-variant PMTO also includes an anode to receive photoelectrons directed from the plurality of dynodes.Type: ApplicationFiled: October 17, 2014Publication date: May 21, 2015Inventors: Derek Mackay, Paul Donders, Kai Cao, Jeongsik Lim
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Publication number: 20100254590Abstract: A system for performing automated cell screening in drug discovery, includes an automated microscope, a fast autofocus device, and a digital imaging system. Processes are implemented in software through which relevant cellular material is segmented and quantified with minimal user interaction. Improvements in the following areas: known to methods for image processing are implemented in such a way that automated segmentation is achieved; sets of known measurements (pixel counting, etc.) are implemented as methods which demonstrate aspects of biology in a reliable fashion; components for automated positioning, focusing, imaging and processing of a multiplicity of samples are integrated as systems within which the segmentation and measurement methods may be mounted; and components and methods are adapted into systems which yield more highly automated and more rapid cell screening.Type: ApplicationFiled: June 17, 2010Publication date: October 7, 2010Applicant: GE HEALTHCARE NIAGARA INC.Inventors: PETER RAMM, YURIY ALEXANDROV, JURICH CYBUCH, PAUL DONDERS, CARLOS ZARATE, BOHDAN J. SOLTYS
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Patent number: 7764822Abstract: A system for performing automated cell screening in drug discovery, includes an automated microscope, a fast autofocus device, and a digital imaging system. Processes are implemented in software through which relevant cellular material is segmented and quantified with minimal user interaction. Improvements in the following areas: known methods for image processing are implemented in such a way that automated segmentation is achieved; sets of known measurements (pixel counting, etc.) are implemented as methods which demonstrate aspects of biology in a reliable fashion; components for automated positioning, focusing, imaging and processing of a multiplicity of samples are integrated as systems within which the segmentation and measurement methods may be mounted; and components and methods are adapted into systems which yield more highly automated and more rapid cell screening.Type: GrantFiled: October 17, 2008Date of Patent: July 27, 2010Assignee: GE Healthcare Niagara Inc.Inventors: Peter Ramm, Yuriy Alexandrov, Jurich Cybuch, Paul Donders, Carlos Zarate, Bohdan Soltys
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Publication number: 20090074283Abstract: A system for performing automated cell screening in drug discovery, includes an automated microscope, a fast autofocus device, and a digital imaging system. Processes are implemented in software through which relevant cellular material is segmented and quantified with minimal user interaction. Improvements in the following areas: known methods for image processing are implemented in such a way that automated segmentation is achieved; sets of known measurements (pixel counting, etc.) are implemented as methods which demonstrate aspects of biology in a reliable fashion; components for automated positioning, focusing, imaging and processing of a multiplicity of samples are integrated as systems within which the segmentation and measurement methods may be mounted; and components and methods are adapted into systems which yield more highly automated and more rapid cell screening.Type: ApplicationFiled: October 17, 2008Publication date: March 19, 2009Applicant: GE HEALTHCARE NIAGARA INC.Inventors: PETER RAMM, Yuriy Alexandrov, Jurich Cybuch, Paul Donders, Carlos Zarate, Bohdan J. Soltys
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Patent number: 7469056Abstract: A system for performing automated cell screening in drug discovery, including an automated microscope, a fast autofocus device and a digital imaging system. Processes are implemented in software through which relevant cellular material is segmented and quantified with minimal user interaction. Improvements in the following areas: known methods for image processing are implemented in such a way that automated segmentation is achieved; sets of known measurements (pixel counting, etc.) are implemented as methods which demonstrate aspects of biology in a reliable fashion; components for automated positioning, focusing, imaging and processing of a multiplicity of samples are integrated as systems within which the segmentation and measurement methods may be mounted; and components and methods are adapted into systems which yield more highly automated and more rapid cell screening.Type: GrantFiled: May 9, 2003Date of Patent: December 23, 2008Assignee: GE Healthcare Niagara Inc.Inventors: Peter Ramm, Yuriy Alexandrov, Jurich Cybuch, Paul Donders, Carlos Zarate, Bohdan J. Soltys
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Patent number: 7335898Abstract: A new and improved confocal fluorescence microscope is presented. The new microscope has significant advantages relative to existing implementations of microscope confocal imagers. In common with previous confocal imagers the instant invention has the advantages relative to conventional wide-field and confocal fluorescence imagers, however it addresses the drawbacks of confocal technology in terms of cost and complexity, and provides significant savings in both due to the simplicity of the components and the elimination of the need of, in particular, spatial filters such as pinholes or slits.Type: GrantFiled: July 19, 2005Date of Patent: February 26, 2008Assignee: GE Healthcare Niagara Inc.Inventors: Paul Donders, Carlos Zarate, Pavel A. Fomitchov
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Publication number: 20060257013Abstract: A system for performing automated cell screening in drug discovery, including an automated microscope, a fast autofocus device and a digital imaging system. Processes are implemented in software through which relevant cellular material is segmented and quantified with minimal user interaction. Improvements in the following areas: known methods for image processing are implemented in such a way that automated segmentation is achieved; sets of known measurements (pixel counting, etc.) are implemented as methods which demonstrate aspects of biology in a reliable fashion; components for automated positioning, focusing, imaging and processing of a multiplicity of samples are integrated as systems within which the segmentation and measurement methods may be mounted; and components and methods are adapted into systems which yield more highly automated and more rapid cell screening.Type: ApplicationFiled: May 9, 2003Publication date: November 16, 2006Inventors: Peter Ramm, Yuriy Alexandrov, Jurich Cybuch, Paul Donders, Carlos Zarate, Bohdan Soltys
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Publication number: 20060017001Abstract: A new and improved confocal fluorescence microscope is presented. The new microscope has significant advantages relative to existing implementations of microscope confocal imagers. In common with previous confocal imagers the instant invention has the advantages relative to conventional wide-field and confocal fluorescence imagers, however it addresses the drawbacks of confocal technology in terms of cost and complexity, and provides significant savings in both due to the simplicity of the components and the elimination of the need of, in particular, spatial filters such as pinholes or slits.Type: ApplicationFiled: July 19, 2005Publication date: January 26, 2006Inventors: Paul Donders, Carlos Zarate, Pavel Fomitchov
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Patent number: 6806455Abstract: The present invention relates to an apparatus and method for imaging time resolved fluorescence in biochemical and medical samples. In a primary aspect, the device includes a lens of large aperture, a flash lamp in the illumination path, a fast-acting solid state shutter or a gated detector in the emission path, a device for delivering homogenous monochromatic illumination to a plurality of wells distributed within a microwell plate, a digital camera of high quantum efficiency, and a computer under computer control, the lamp is pulsed at short intervals. The fast-acting emission shutter or gated detector operates to limit exposure of the camera to a period some microseconds after the extinction of each lamp pulse, during which only delayed fluorescence is transmitted to the camera. The invention achieves simultaneous time resolved imaging of a plurality of samples, with high sensitivity and high throughput.Type: GrantFiled: September 30, 2002Date of Patent: October 19, 2004Assignee: Imaging Research Inc.Inventors: Carlos Zarate, Paul Donders, Ahmad Yekta, Zahra Masoumi, Peter Ramm
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Publication number: 20030160151Abstract: The present invention relates to an apparatus and method for imaging time resolved fluorescence in biochemical and medical samples. In a primary aspect, the device includes a lens of large aperture, a flash lamp in the illumination path, a fast-acting solid state shutter or a gated detector in the emission path, a device for delivering homogenous monochromatic illumination to a plurality of wells distributed within a microwell plate, a digital camera of high quantum efficiency, and a computer under computer control, the lamp is pulsed at short intervals. The fast-acting emission shutter or gated detector operates to limit exposure of the camera to a period some microseconds after the extinction of each lamp pulse, during which only delayed fluorescence is transmitted to the camera. The invention achieves simultaneous time resolved imaging of a plurality of samples, with high sensitivity and high throughput.Type: ApplicationFiled: September 30, 2002Publication date: August 28, 2003Inventors: Carlos Zarate, Paul Donders, Ahmad Yekta, Zahra Masoumi, Peter Ramm