Patents by Inventor Paul F. Worley
Paul F. Worley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220187321Abstract: Disclosed herein are methods for diagnosing a subject as having a neurological disorder, such as Alzheimer's disease, using proximity-based detection assays capable of detecting complexes containing two or more synaptic proteins, such as neuronal pentraxins, from a blood, cerebrospinal fluid, or other fluid sample of the subject. Also disclosed are methods of evaluating and monitoring subjects having or at risk of developing a neurological disorder using the aforementioned assays.Type: ApplicationFiled: December 16, 2021Publication date: June 16, 2022Inventors: Paul F. WORLEY, Meifang XIAO, Desheng XU
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Patent number: 10914749Abstract: The present invention relates to the field of cognitive function. More specifically, the present invention provides compositions and methods useful for assessing cognitive dysfunction/function in Alzheimer's disease and other diseases of cognition. In one embodiment, the method comprises the steps of (a) reducing heterocomplexes comprising NPTX1 and NPTX2 present in a biological sample obtained from the patient into NPTX1 and NPTX2 monomers; (b) covalently modifying the thiol groups of the NPTX1 and NPTX2 monomers to prevent re-formation of NPTX1/NPTX2 heterocomplexes; (c) detecting NPTX2 in the sample; and (d) assessing cognitive function in the patient by comparing NPTX2 detected in the sample to a control.Type: GrantFiled: February 1, 2019Date of Patent: February 9, 2021Assignee: The Johns Hopkins UniversityInventors: Paul F. Worley, DeSheng Xu, Meifang Xiao
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Publication number: 20190353668Abstract: The present invention relates to the field of cognitive function. More specifically, the present invention provides compositions and methods useful for assessing cognitive dysfunction/function in Alzheimer's disease and other diseases of cognition. In one embodiment, the method comprises the steps of (a) reducing heterocomplexes comprising NPTX1 and NPTX2 present in a biological sample obtained from the patient into NPTX1 and NPTX2 monomers; (b) covalently modifying the thiol groups of the NPTX1 and NPTX2 monomers to prevent re-formation of NPTX1/NPTX2 heterocomplexes; (c) detecting NPTX2 in the sample; and (d) assessing cognitive function in the patient by comparing NPTX2 detected in the sample to a control.Type: ApplicationFiled: February 1, 2019Publication date: November 21, 2019Inventors: Paul F. Worley, DeSheng Xu, Meifang Xiao
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Patent number: 10222386Abstract: The present invention relates to the field of cognitive function. More specifically, the present invention provides compositions and methods useful for assessing cognitive dysfunction/function in Alzheimer's disease and other diseases of cognition. In one embodiment, the method comprises the steps of (a) reducing heterocomplexes comprising NPTX1 and NPTX2 present in a biological sample obtained from the patient into NPTX1 and NPTX2 monomers; (b) covalently modifying the thiol groups of the NPTX1 and NPTX2 monomers to prevent re-formation of NPTX1/NPTX2 heterocomplexes; (c) detecting NPTX2 in the sample; and (d) assessing cognitive function in the patient by comparing NPTX2 detected in the sample to a control.Type: GrantFiled: September 18, 2015Date of Patent: March 5, 2019Assignee: The Johns Hopkins UniversityInventors: Paul F. Worley, DeSheng Xu, Meifang Xiao
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Publication number: 20170292963Abstract: The present invention relates to the field of cognitive function. More specifically, the present invention provides compositions and methods useful for assessing cognitive dysfunction/function in Alzheimer's disease and other diseases of cognition. In one embodiment, the method comprises the steps of (a) reducing heterocomplexes comprising NPTX1 and NPTX2 present in a biological sample obtained from the patient into NPTX1 and NPTX2 monomers; (b) covalently modifying the thiol groups of the NPTX1 and NPTX2 monomers to prevent re-formation of NPTX1/NPTX2 heterocomplexes; (c) detecting NPTX2 in the sample; and (d) assessing cognitive function in the patient by comparing NPTX2 detected in the sample to a control.Type: ApplicationFiled: September 18, 2015Publication date: October 12, 2017Inventors: Paul F. Worley, DeSheng Xu, Meifang Xiao
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Publication number: 20090123940Abstract: The present invention is based on the discovery that neuronal pentraxins play a role in the clustering and internalization of AMPA receptors, synaptogenesis, and metabotropic glutamate receptor-mediated long term depression (LTD) of a synapse. Accordingly, there are provided methods of identifying compounds that that modulate mGluR-mediated AMPA receptor internalization and LTD. Further provided are cleavage products of a member of the neuronal pentraxin family, neuronal pentraxin receptor (NPR). Also provided are isolated peptides comprising the Narp association regions 1 and 2 (NAR1 and NAR2, respectively) and the Narp binding motif (NBM) of AMPA receptors. Finally, there are provided antibodies that block binding of neuronal pentraxins to AMPA receptors, in particular, antibodies that bind NAR1, or NAR2, or NBM.Type: ApplicationFiled: October 10, 2008Publication date: May 14, 2009Applicant: THE JOHNS HOPKINS UNIVERSITYInventors: Paul F. Worley, Desheng Xu, Richard William Cho, Radhika Chinthamani Reddy
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Patent number: 7442513Abstract: The invention features a method of identifying, evaluating and screening for compounds or agents for the treatment of disorders involving the Homer signaling pathway in the modulation of immunosupression and neuroprotection. The method includes evaluating the ability of agents to modulate Homer protein activity, Homer protein/immunophilin-peptidylproline cis-trans isomerase interaction, and/or Homer protein/proline-type Homer ligand consensus sequence interaction to identify agents for such treatment. The invention also discloses treatment modalities involving agents identified by such methods.Type: GrantFiled: June 18, 2003Date of Patent: October 28, 2008Assignee: The Johns Hopkins UniversityInventor: Paul F. Worley
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Patent number: 7399830Abstract: Disclosed are nucleotide coding sequences and polypeptide sequences for synaptic activation binding proteins that are characterized by induction in the central nervous system following neuronal activity in rat hippocampus. Such proteins are identified by (i) substantial homology at the nucleotide or protein sequence level to specifically defined rat, human or mouse coding sequences or proteins, (ii) ability to bind to and affect the activity of effector proteins in the CNS, such as metabotropic glutamate receptors, (iii) binding specificity for a particular binding sequence, and (iv) presence in the sequence of a PDZ-like domain. Nucleotides and polypeptides of the invention are useful in screening and diagnostic assays.Type: GrantFiled: June 10, 2004Date of Patent: July 15, 2008Assignee: Johns Hopkins UniversityInventors: Paul F. Worley, Paul R. Brakeman
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Patent number: 7378498Abstract: A method is provided for identifying a compound that modulates a cellualr response associated with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor activated calcium mobilization associated with Homer. A method is provided for identifying a compound that inhibits Homer protein activity based on the crystal structure coordinates of Homer protein binding domain. A method is also provided for identifying a compound that affects the formation of cell surface receptors into clusters. Also provided are nucleic acids encoding Homer proteins as well as Homer proteins, and Homer interacting proteins.Type: GrantFiled: December 10, 2004Date of Patent: May 27, 2008Assignee: The Johns Hopkins University School of MedicineInventors: Paul F. Worley, Jian Cheng Tu, Bo Xiao, Daniel Leahy, Jutta Beneken, Anthony A. Lanahan, Paul R. Brakeman
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Patent number: 6864083Abstract: A method is provided for identifying a compound that modulates a cellualr response associate with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor activated calcium mobilization associated with Homer. A method is provided for identifying a compound that inhibits Homer protein activity based on the crystal structure coordinates of Homer protein binding domain. A method is also provided for identifying a compound that affects the formation of cell surface receptors into clusters. Also provided are nucleic acids encoding Homer proteins as well as Homer proteins, and Homer interacting proteins.Type: GrantFiled: July 9, 2002Date of Patent: March 8, 2005Inventors: Paul F. Worley, Jian Cheng Tu, Bo Xiao, Daniel Leahy, Jutta Beneken, Anthony A. Lanahan, Paul R. Brakeman
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Publication number: 20040260058Abstract: The present invention relates to novel, specifically expressed proteins and to nucleic acid sequences or transgenic nucleic acid constructs which encode the proteins.Type: ApplicationFiled: June 3, 2004Publication date: December 23, 2004Inventors: Sigrid Scheek, Holger Hiemisch, Anthony Lanahan, Jean B. Regard, Paul F. Worley, Eckart Krupp, Markus Schwaninger, Nauder Faraday
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Publication number: 20040229274Abstract: Disclosed are nucleotide coding sequences and polypeptide sequences for synaptic activation binding proteins that are characterized by induction in the central nervous system following neuronal activity in rat hippocampus. Such proteins are identified by (i) substantial homology at the nucleotide or protein sequence level to specifically defined rat, human or mouse coding sequences or proteins, (ii) ability to bind to and affect the activity of effector proteins in the CNS, such as metabotropic glutamate receptors, (iii) binding specificity for a particular binding sequence, and (iv) presence in the sequence of a PDZ-like domain. Nucleotides and polypeptides of the invention are useful in screening and diagnostic assays.Type: ApplicationFiled: June 10, 2004Publication date: November 18, 2004Applicant: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINEInventors: Paul F. Worley, Paul R. Brakeman
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Patent number: 6780600Abstract: Disclosed are nucleotide coding sequences and polypeptide sequences for synaptic activation binding proteins that are characterized by induction in the central nervous system following neuronal activity in rat hippocampus. Such proteins are identified by (i) substantial homology at the nucleotide or protein sequence level to specifically defined rat, human or mouse coding sequences or proteins, (ii) ability to bind to and affect the activity of effector proteins in the CNS, such as metabotropic glutamate receptors, (iii) binding specificity for a particular binding sequence, and (iv) presence in the sequence of a PDZ-like domain. Nucleotides and polypeptides of the invention are useful in screening and diagnostic assays.Type: GrantFiled: July 20, 2001Date of Patent: August 24, 2004Assignee: The Johns Hopkins University School of MedicineInventors: Paul F. Worley, Paul R. Brakeman
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Publication number: 20040152658Abstract: The present invention provides methods and materials related to immediate early genes. Specifically, the invention provides isolated immediate early gene nucleic acid, cells that contain isolated immediate early gene nucleic acid, substantially pure polypeptides encoded by immediate early gene nucleic acid, and antibodies having specific binding affinity for a polypeptide encoded by immediate early gene nucleic acid. In addition, the invention provides cDNA libraries enriched for immediate early genes cDNAs, isolated nucleic acid derived from such cDNA libraries, and methods for treating conditions related to a deficiency in a neuron's immediate early gene responsiveness to a stimulus.Type: ApplicationFiled: March 2, 2004Publication date: August 5, 2004Applicants: THE JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE, BASF-LYNX BIOSCIENCE AG, LYNX THERAPEUTICS, INC.Inventors: Paul F. Worley, Anthony Lanahan, Bernhard Goetz, Holger Hiemisch, Rohini Kuner, Sigrid Scheek, Karoly Nikolich, Eugene Zhukovsky
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Patent number: 6720175Abstract: A method is provided for identifying a compound that modulates a cellular response associated with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor activated calcium mobilization associated with Homer. A method is provided for identifying a compound that inhibits Homer protein activity based on the crystal structure coordinates of Homer protein binding domain. A method is also provided for identifying a compound that affects the formation of cell surface receptors into clusters. Also provided are nucleic acids encoding Homer proteins as well as Homer proteins, and Homer interacting proteins.Type: GrantFiled: August 18, 1999Date of Patent: April 13, 2004Assignee: The Johns Hopkins University School of MedicineInventors: Paul F. Worley, Jian Cheng Tu, Bo Xiao, Daniel Leahy, Jutta Beneken, Anthony A. Lanahan, Paul R. Brakeman
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Patent number: 6699660Abstract: The present invention provides methods and materials related to immediate early genes. Specifically, the invention provides isolated immediate early gene nucleic acid, cells that contain isolated immediate early gene nucleic acid, substantially pure polypeptides encoded by immediate early gene nucleic acid, and antibodies having specific binding affinity for a polypeptide encoded by immediate early gene nucleic acid. In addition, the invention provides cDNA libraries enriched for immediate early genes cDNAs, isolated nucleic acid derived from such cDNA libraries, and methods for treating conditions related to a deficiency in a neuron's immediate early gene responsiveness to a stimulus.Type: GrantFiled: February 5, 1999Date of Patent: March 2, 2004Assignee: The Johns Hopkins University School of MedicineInventors: Paul F. Worley, Anthony Lanahan, Bernhard Goetz, Holger Hiemisch, Rohini Kuner, Sigrid Scheek, Karoly Nikolich, Eugene Zhukovsky
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Publication number: 20030203840Abstract: The present invention provides methods and materials related to immediate early genes. Specifically, the invention provides isolated immediate early gene nucleic acid, cells that contain isolated immediate early gene nucleic acid, substantially pure polypeptides encoded by immediate early gene nucleic acid, and antibodies having specific binding affinity for a polypeptide encoded by immediate early gene nucleic acid. In addition, the invention provides cDNA libraries enriched for immediate early genes cDNAs, isolated nucleic acid derived from such cDNA libraries, and methods for treating conditions related to a deficiency in a neuron's immediate early gene responsiveness to a stimulus.Type: ApplicationFiled: February 5, 1999Publication date: October 30, 2003Inventors: PAUL F. WORLEY, ANTHONY LANAHAN, BERNHARD GOETZ, HOLGER HIEMISCH, ROHINI KUNER, SIGRID SCHEEK, KAROLY NIKOLICH, EUGENE ZHUKOVSKI
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Publication number: 20030170807Abstract: A method is provided for identifying a compound that modulates a cellualr response associate with Homer and mediated by a cell-surface or an intracellular receptor. A method is further provided for identifying a compound that modulates receptor activated calcium mobilization associated with Homer. A method is provided for identifying a compound that inhibits Homer protein activity based on the crystal structure coordinates of Homer protein binding domain. A method is also provided for identifying a compound that affects the formation of cell surface receptors into clusters. Also provided are nucleic acids encoding Homer proteins as well as Homer proteins, and Homer interacting proteins.Type: ApplicationFiled: July 9, 2002Publication date: September 11, 2003Applicant: The Johns Hopkins University School of MedicineInventors: Paul F. Worley, Jian Cheng Tu, Bo Xiao, Daniel Leahy, Jutta Beneken, Anthony A. Lanahan, Paul R. Brakeman
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Publication number: 20030027147Abstract: Disclosed are nucleotide coding sequences and polypeptide sequences for synaptic activation binding proteins that are characterized by induction in the central nervous system following neuronal activity in rat hippocampus. Such proteins are identified by (i) substantial homology at the nucleotide or protein sequence level to specifically defined rat, human or mouse coding sequences or proteins, (ii) ability to bind to and affect the activity of effector proteins in the CNS, such as metabotropic glutamate receptors, (iii) binding specificity for a particular binding sequence, and (iv) presence in the sequence of a PDZ-like domain. Nucleotides and polypeptides of the invention are useful in screening and diagnostic assays.Type: ApplicationFiled: July 20, 2001Publication date: February 6, 2003Inventors: Paul F. Worley, Paul R. Brakeman
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Patent number: 6294355Abstract: Disclosed are nucleotide coding sequences and polypeptide sequences for synaptic activation binding proteins that are characterized by induction in the central nervous system following neuronal activity in rat hippocampus. Such proteins are identified by (i) substantial homology at the nucleotide or protein sequence level to specifically defined rat, human or mouse coding sequences or proteins, (ii) ability to bind to and affect the activity of effector proteins in the CNS, such as metabotropic glutamate receptors, (iii) binding specificity for a particular binding sequence, and (iv) presence in the sequence of a PDZ-like domain. Nucleotides and polypeptides of the invention are useful in screening and diagnostic assays.Type: GrantFiled: March 13, 1998Date of Patent: September 25, 2001Assignee: The Johns Hopkins University School of MedicineInventors: Paul F. Worley, Paul R. Brakeman