Abstract: The present disclosure provides aerosol generating substrates and aerosol source members comprising aerosol generating substrates, as well as methods of manufacturing thereof. In an example implementation, an aerosol generating substrate may comprise a fibrous filler material, an aerosol forming material, and a plurality of heat conducting constituents, wherein the substrate is formed as a sheet, and wherein the heat conducting constituents are part of the sheet. The heat conducting constituents may be incorporated within the sheet, or may be formed on a surface of the sheet. In another example implementation, an aerosol source member may comprise a substrate portion formed of a collection of intermingled pieces cut from an aerosol substrate sheet. In addition, or alternatively, a substrate portion may be formed of a series of overlapping layers of an aerosol substrate sheet.

Abstract: A method of reducing IL-4 and/or IL-13 levels in the lung of a mammal with elevated levels thereof, includes the step of administering to the mammal an effective amount of a ?c receptor blocker capable of blocking the binding of all three of IL-3, IL-5 and GM-CSF to the ?c common chain to thereby reduce the IL-4 and/or IL-13 levels.

Abstract: Automated real-time aerial change assessment of targets is provided. An aerial image of a target area is recorded during a flyover and a target detected in the aerial image. A sequence of images of the target area are recorded during a subsequent flyover. The system determines a target detection probability according to confidence scores of the sequence of images and determines a change status of the target. Responsive to a target change, a percentage of change is determined according to image feature matching between first aerial image and each of the images from the second flyover. Target detection probability and percentage of change are combined as statistically independent events to determine a probability of change. The probability of change and percentage of change for each image in the sequence is output in real-time, and final change assessment is output when the aircraft exits the target area.

Abstract: This invention features compositions, methods, and kits for treating conditions associated with pathological ocular neovascularization, reducing scarring in the eye, treating dry eye, treating macular degeneration, and treating keratitis by administering a serotonin receptor agonist.

Abstract: This invention is directed to compositions, methods and kits for ameliorating or reducing pathogenesis of a disease by administering to a subject a serotonin receptor agonist.

Abstract: One variation of a method for registering distance scan data includes: accessing a first distance scan recorded, at a first time, by a first depth sensor defining a first field of view; accessing a second distance scan recorded, at approximately the first time, by a second depth sensor defining a second field of view overlapping a portion of the first field of view; calculating a first set of lines represented by points in a first portion of the first distance scan overlapping a second portion of the second distance scan; calculating a second set of lines represented by points in the second portion of the second distance scan; calculating skew distances between each pair of corresponding lines in the first and second sets of lines; and calculating an alignment transformation that aligns the first distance scan and the second distance scan to minimize skew distances between corresponding pairs of lines.

Abstract: Provided herein, in certain aspects, are methods of treating a cancer in a subject, comprising administering a bispecific anti-CTLA4×anti-PD1 antibody to the subject.

Abstract: Systems and methods for perceiving a field around a mobile device include a sensor system has a distance sensor arranged on a mobile device. The sensor system captures distance measurements of a field of view. The distance measurements are captured at a unique set of angular scan positions per revolution of the distance sensor over a sequence of scan rotations. A perception system generates a three-dimensional point cloud representation of the field of view based on the distance measurements for each scan rotation in the sequence of scan rotations. The perception system generates a composite three-dimensional depth map of the field of view by compiling each of the three-dimensional point cloud representations for the sequence of scan rotations. Each of the three-dimensional point cloud representations has a resolution that is lower than a resolution of the composite three-dimensional depth map of the field of view.

Abstract: The present disclosure relates to immunoglobulins that bind Fc?RIIb+ B cells and coengage CD19 on the cell's surface and an Fc?RIIb on the cell's surface, methods for their generation, and methods for using the immunoglobulins for the treatment of an IgG4-related disease.

Abstract: The present disclosure relates to immunoglobulins that bind Fc?RIIb+ B cells and coengage CD19 on the cell's surface and an Fc?RIIb on the cell's surface, methods for their generation, and methods for using the immunoglobulins for the treatment of an IgG4-related disease.

Abstract: The present invention is directed to antibodies, including novel antigen binding domains and heterodimeric antibodies, that bind somatostatin receptor 2 (SSTR2)

Abstract: The present invention is directed to antibodies, including novel antigen binding domains and heterodimeric antibodies, that bind somatostatin receptor 2 (SSTR2).

Abstract: A method of reducing IL-4 and/or IL-13 levels in the lung of a mammal with elevated levels thereof, includes the step of administering to the mammal an effective amount of a ?c receptor blocker capable of blocking the binding of all three of IL-3, IL-5 and GM-CSF to the ?c common chain to thereby reduce the IL-4 and/or IL-13 levels.

Abstract: The methods described here are directed to treating human subjects with bispecific anti-CD 123×anti-CD3 antibodies.

Abstract: The methods described here are directed to treating human subjects with bispecific anti-CD 123×anti-CD3 antibodies.

Abstract: The present invention is directed to novel bispecific anti-CD123 x anti-CD3 antibodies.

Abstract: The present invention is directed to methods of administrating bispecific anti-CD20×anti-CD3 antibodies.

Abstract: The present invention is directed to methods for treating a solid cancerous cancer through administering a bispecific anti-PD1 x anti-CTLA4 antibody.

Abstract: This invention features compositions, methods, and kits for treating conditions associated with pathological ocular neovascularization, reducing scarring in the eye, treating dry eye, treating macular degeneration, and treating keratitis by administering a serotonin receptor agonist.

Abstract: The present invention is directed to novel bispecific anti-CD 123×anti-CD3 antibodies.