Patents by Inventor Paul H. Ehrlich

Paul H. Ehrlich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Immunoassay for human chorionic gonadotropin
    Patent number: 4851356
    Abstract: An immunoassay for detecting and measuring hCG in a sample includes an antibody directed to the carboxy terminal portion of the .beta. subunit of hCG and a monoclonal antibody directed to a determinant on hCG at a locus sufficiently remote from the carboxy terminal portion of the .beta. subunit of hCG that both antibodies can simultaneously bind to hCG, wherein at least one of the antibodies is delectable when both are bound to hCG.In a presently preferred embodiment, an immunoassay for hCG or hCB.beta. in urine includes a purified, labeled or detectable serum-derived antibody directed to the carboxy-terminal portion of the .beta. subunit of hCG and a matrix-bound monoclonal antibody directed to a locus on the .beta. subunit sufficiently remote from the carboxy-terminal portion that both antibodies can simultaneously bind to hCG or hCG.beta..
    Type: Grant
    Filed: July 14, 1987
    Date of Patent: July 25, 1989
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Robert E. Canfield, Elmo G. Armstrong, Paul H. Ehrlich, Steven Birken
  • Methods for obtaining monoclonal antibodies useful in enhanced sensitivity immunoassays
    Patent number: 4792528
    Abstract: Mixtures of monoclonal antibodies which contain effective assaying amounts of each of at least two monoclonal antibodies that bind to different antigenic sites on the antigen and are capable under appropriate conditions of binding simultaneously to an antigen are useful in enhanced sensitivity assays for the antigen. By utilizing such mixtures in diagnostic assays for important antigens such as the polypeptide human chorionic gonadotropin enhanced sensitivity can be achieved as compared with assays employing individual monoclonal antibodies.
    Type: Grant
    Filed: February 19, 1987
    Date of Patent: December 20, 1988
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Robert E. Canfield, Paul H. Ehrlich, William R. Moyle
  • Monoclonal antibody mixtures and use thereof for enhanced sensitivity immunoassays
    Patent number: 4514505
    Abstract: Mixtures of monoclonal antibodies which contain effective assaying amounts of each of at least two monoclonal antibodies that bind to different antigenic sites on the antigen and are capable under appropriate conditions of binding simultaneously to an antigen are useful in enhanced sensitivity assays for the antigen. By utilizing such mixtures in diagnostic assays for important antigens such as the polypeptide human chorionic gonadotropin enhanced sensitivity can be achieved as compared with assays employing individual monoclonal antibodies.
    Type: Grant
    Filed: May 21, 1982
    Date of Patent: April 30, 1985
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Robert E. Canfield, Paul H. Ehrlich, William R. Moyle
  • Antibody fragment compositions and process
    Patent number: 4355023
    Abstract: Immunologically active rabbit IgG antibody fragment compositions are produced by isolating the anti-light variable chain of rabbit IgG and/or the anti-heavy variable chain of rabbit IgG and combining them with each other or with the complementary heavy or light chain of rabbit IgG.
    Type: Grant
    Filed: September 30, 1980
    Date of Patent: October 19, 1982
    Assignee: The Massachusetts General Hospital
    Inventors: Paul H. Ehrlich, Gary R. Matsueda, Michael N. Margolies, Edgar Haber