Patents by Inventor Paul H. Patterson

Paul H. Patterson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS COMPRISING BACTERIA FOR IMPROVING BEHAVIOR IN NEURODEVELOPMENTAL DISORDERS
    Publication number: 20160120920
    Abstract: Some embodiments include bacterial species for use in treatment of one or more autism spectrum disorder (ASD), and/or schizophrenia symptoms in a subject in need thereof. The bacterial species can include Bacteroides (e.g., B. fragilis, B. thetaiomtaomicron, and/or B. vulgatus), and/or Enterococcus (e.g., E. faecalis, E. faecium, E. hirae, E. avium, E. durans, E. gallinarum, or E. casseliflavus). Upon treatment, one or more ASD-related behaviors can be improved in the subject.
    Type: Application
    Filed: October 28, 2015
    Publication date: May 5, 2016
    Inventors: Elaine Hsiao, Sara McBride, Sarkis K. Mazmanian, Paul H. Patterson
  • COMPOSITIONS AND METHODS COMPRISING BACTERIA FOR IMPROVING BEHAVIOR IN NEURODEVELOPMENTAL DISORDERS
    Publication number: 20160120916
    Abstract: Some embodiments include probiotics for use in treatment of one or more autism spectrum disorder (ASD) or epilepsy in a subject in need thereof. The probiotics can comprise Bacteroides bacteria (e.g., B. fragilis). In some embodiments, the subject is identified in need of treatment ASD or epilepsy based a combination of behavioral symptoms and optional genetic markers. Upon treatment, one or more ASD-related behaviors are improved in the subject.
    Type: Application
    Filed: October 28, 2015
    Publication date: May 5, 2016
    Inventors: Elaine Hsiao, Wei-Li Wu, Sarkis K. Mazmanian, Paul H. Patterson
  • SELECTIVE RECOVERY
    Publication number: 20150079038
    Abstract: Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.
    Type: Application
    Filed: September 12, 2014
    Publication date: March 19, 2015
    Inventors: Benjamin E. Deverman, Paul H. Patterson
  • DIAGNOSIS AND TREATMENT OF AUTISM SPECTRUM DISORDER
    Publication number: 20140065132
    Abstract: Disclosed herein are compositions, systems, and methods for diagnosing and treatment of subjects suffering from anxiety, autism spectrum disorder (ASD), or a pathological condition with one or more of the symptoms of ASD.
    Type: Application
    Filed: August 28, 2013
    Publication date: March 6, 2014
    Inventors: Elaine Hsiao, Sarkis K. Mazmanian, Paul H. Patterson, Sara McBride
  • DNA-damage-induced proteolysis
    Patent number: 8318446
    Abstract: The present application provides methods for identifying compounds for inhibiting DNA damage-induced Htt proteolysis, and methods and compositions for protecting cells from DNA damage-induced cleavage of Htt.
    Type: Grant
    Filed: December 4, 2009
    Date of Patent: November 27, 2012
    Assignee: California Institute of Technology
    Inventors: Ali Khoshnan, Paul H Patterson
  • Probiotic Therapies for Autism
    Publication number: 20120087895
    Abstract: Provided is a method and a composition for improving behavioral performance in an individual comprising identifying an individual in need of treatment, and providing such an individual a composition comprising bacteria within the genus Bacteroides.
    Type: Application
    Filed: October 6, 2011
    Publication date: April 12, 2012
    Inventors: Sarkis K. Mazmanian, Paul H. Patterson, Janet Chow, Elaine Hsiao, Sara McBride
  • I kappa B kinase complex as a target for the treatment of Huntington's disease
    Patent number: 7803758
    Abstract: The present invention provides methods and compositions for protecting cells from the toxicity of mutant huntingtin (Htt) protein and for treatment of Huntington's disease (HD). The methods generally involve administering to cells or a patient an effective amount of an IKK inhibitor. In addition, methods are provided for identifying therapeutics for the treatment of HD.
    Type: Grant
    Filed: October 9, 2007
    Date of Patent: September 28, 2010
    Assignee: California Institute of Technology
    Inventors: Ali Khoshnan, Paul H. Patterson
  • ANTIBODIES THAT BIND TO AN EPITOPE ON THE HUNTINGTON'S DISEASE PROTEIN
    Publication number: 20100233180
    Abstract: The present invention relates generally to the generation and characterization of anti-huntingtin antibodies binding an epitope on the Huntington's disease protein. The invention further relates to the use of such anti-huntingtin antibodies in the diagnosis and treatment of Huntington's disease.
    Type: Application
    Filed: March 19, 2010
    Publication date: September 16, 2010
    Applicant: California Institute of Technology
    Inventors: Ali Khoshnan, Jan Ko, Paul H. Patterson
  • DNA-DAMAGE-INDUCED PROTEOLYSIS
    Publication number: 20100143945
    Abstract: The present application provides methods for identifying compounds for inhibiting DNA damage-induced Htt proteolysis, and methods and compositions for protecting cells from DNA damage-induced cleavage of Htt.
    Type: Application
    Filed: December 4, 2009
    Publication date: June 10, 2010
    Applicant: California Institute of Technology
    Inventors: Ali Khoshnan, Paul H. Patterson
  • Antibodies that bind to an epitope on the Huntington's disease protein
    Patent number: 7375194
    Abstract: The present invention relates generally to the generation and characterization of anti-huntingtin antibodies binding an epitope on the Huntington's disease protein. The invention further relates to the use of such anti-huntingtin antibodies in the diagnosis and treatment of Huntington's disease.
    Type: Grant
    Filed: January 28, 2003
    Date of Patent: May 20, 2008
    Assignee: California Institute of Technology
    Inventors: Ali Khoshnan, Jan Ko, Paul H. Patterson
  • I KAPPA B KINASE COMPLEX AS A TARGET FOR THE TREATMENT OF HUNTINGTON'S DISEASE
    Publication number: 20080112947
    Abstract: The present invention provides methods and compositions for protecting cells from the toxicity of mutant huntingtin (Htt) protein and for treatment of Huntington's disease (HD). The methods generally involve administering to cells or a patient an effective amount of an IKK inhibitor. In addition, methods are provided for identifying therapeutics for the treatment of HD.
    Type: Application
    Filed: October 9, 2007
    Publication date: May 15, 2008
    Applicant: California Institute of Technology
    Inventors: Ali Khoshnan, Paul H. Patterson
  • I kappa B kinase complex as a target for the treatment of Huntington's disease
    Patent number: 7279288
    Abstract: The present invention provides methods and compositions for protecting cells from the toxicity of mutant huntingtin (Htt) protein and for treatment of Huntington's disease (HD). The methods generally involve administering to cells or a patient an effective amount of an IKK inhibitor. In addition, methods are provided for identifying therapeutics for the treatment of HD.
    Type: Grant
    Filed: September 1, 2005
    Date of Patent: October 9, 2007
    Assignee: California Institute of Technology
    Inventors: Ali Khoshnan, Paul H. Patterson
  • LIF for use in modulating inflammation and pain
    Patent number: 6753320
    Abstract: A method for inhibiting and/or reducing inflammation and/or pain in an individual is provided, as well as edema and macrophage infiltration associated with inflammation. The method comprises administration of leukemia inhibitory factor (LIF) to a cell or an individual in an amount effective to inhibit and/or reduce inflammation and/or pain.
    Type: Grant
    Filed: November 13, 2000
    Date of Patent: June 22, 2004
    Assignee: California Institute of Technology
    Inventors: Paul H. Patterson, Clifford J. Woolf
  • Antibodies that bind to an epitope on the Huntington's disease protein
    Publication number: 20030232052
    Abstract: The present invention relates generally to the generation and characterization of anti-huntingtin antibodies binding an epitope on the Huntington's disease protein. The invention further relates to the use of such anti-huntingtin antibodies in the diagnosis and treatment of Huntington's disease.
    Type: Application
    Filed: January 28, 2003
    Publication date: December 18, 2003
    Inventors: Ali Khoshnan, Jan Ko, Paul H. Patterson
  • Compositions and methods of treating cancer using compositions comprising an inhibitor or endothelin receptor activity
    Patent number: 6545048
    Abstract: Described herein are results which show that an endothelin receptor antagonist, BQ788, increases pigmentation and significantly reduces the viability of 7 human melanoma cell lines in culture. Moreover, it is described herein that administration of BQ788 significantly slows melanoma tumor growth in nude mice, including a complete growth arrest in half of the mice treated systemically. Thus, inhibitors of endothelin receptor activity are described herein as beneficial for the treatment of cancer.
    Type: Grant
    Filed: September 23, 1999
    Date of Patent: April 8, 2003
    Assignee: California Institute of Technology
    Inventors: Paul H. Patterson, Ronit Lahav
  • Leukemia inhibitory factor for use in modulating inflammation and pain
    Patent number: 6156729
    Abstract: A method for inhibiting and/or reducing inflammation and/or pain in an individual is provided. The method comprises administration of leukemia inhibitory factor (LIF) to a cell or an individual in an amount effective to inhibit and/or reduce inflammation and/or pain.
    Type: Grant
    Filed: October 15, 1998
    Date of Patent: December 5, 2000
    Assignee: California Institute of Technology
    Inventors: Paul H. Patterson, Clifford J. Woolf
  • Stimulation of nerve growth and/or vitality
    Patent number: 5968905
    Abstract: The protein, cholinergic neuronal differentiation factor (CDF), also known as leukemia inhibitory factor (LIF), is described, together with the use of the polypeptide to stimulate neuron growth and survival in animals either by direct administration or by autotransplantation of adrenal medullary cells converted to the cholinergic phenotype.
    Type: Grant
    Filed: August 1, 1997
    Date of Patent: October 19, 1999
    Assignee: California Institute of Technology
    Inventor: Paul H. Patterson
  • Stimulation of nerve growth and/or vitality
    Patent number: 5843892
    Abstract: The protein, cholinergic neuronal differentiation factor (CDF), also known as leukemia inhibitory factor (LIF), is described, together with the use of the polypeptide to stimulate neuron growth and survival in animals either by direct administration or by autotransplantation of adrenal medullary cells converted to the cholinergic phenotype.
    Type: Grant
    Filed: November 18, 1993
    Date of Patent: December 1, 1998
    Assignee: California Institute of Technology
    Inventor: Paul H. Patterson