Patents by Inventor Paul H. Tewson

Paul H. Tewson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • GENETICALLY ENCODED FLUORESCENT SENSORS FOR DETECTING LIGAND BIAS AND INTRACELLULAR SIGNALING THROUGH cAMP PATHWAYS
    Publication number: 20220404357
    Abstract: Described herein are novel fluorescent sensors for cyclic adenosine monophosphate (cAMP) that are based on single fluorescent proteins. These sensors use less visible spectrum than FRET-based sensors, produce robust changes in fluorescence, and can be combined with one another, or with other sensors, in a multiplex assay on standard fluorescent plate readers or live cell imaging systems.
    Type: Application
    Filed: May 25, 2022
    Publication date: December 22, 2022
    Inventors: Thomas E. HUGHES, Paul H. TEWSON, Anne Marie QUINN
  • Genetically encoded fluorescent sensors for detecting ligand bias and intracellular signaling through cAMP pathways
    Patent number: 11366114
    Abstract: Described herein are novel fluorescent sensors for cyclic adenosine monophosphate (cAMP) that are based on single fluorescent proteins. These sensors use less visible spectrum than FRET-based sensors, produce robust changes in fluorescence, and can be combined with one another, or with other sensors, in a multiplex assay on standard fluorescent plate readers or live cell imaging systems.
    Type: Grant
    Filed: November 4, 2014
    Date of Patent: June 21, 2022
    Assignee: Montana Molecular LLC
    Inventors: Thomas E. Hughes, Paul H. Tewson, Anne Marie Quinn
  • Genetically encoded fluorescent sensors for detecting intracellular signalling through diacylglycerol pathways
    Patent number: 10131960
    Abstract: Described herein are novel fluorescent sensors for Diacyl Glycerol (DAG) and phosphatidylinositol 4,5-bisphosphate (PIP2) that are based on circularly permuted fluorescent proteins. These sensors use less visible spectrum than FRET-based sensors, produce robust changes in fluorescence, and can be combined with one another, or with other sensors, in a multiplex assay on standard fluorescent plate readers or live cell imaging systems.
    Type: Grant
    Filed: January 16, 2017
    Date of Patent: November 20, 2018
    Assignee: Montana Molecular LLC
    Inventors: Thomas E. Hughes, Paul H. Tewson, Anne Marie Quinn
  • Genetically Encoded Fluorescent Sensors for Detecting Intracellular Signalling Through Diacylglycerol Pathways
    Publication number: 20170198364
    Abstract: Described herein are novel fluorescent sensors for Diacyl Glycerol (DAG) and phosphatidylinositol 4,5-bisphosphate (PIP2) that are based on circularly permuted fluorescent proteins. These sensors use less visible spectrum than FRET-based sensors, produce robust changes in fluorescence, and can be combined with one another, or with other sensors, in a multiplex assay on standard fluorescent plate readers or live cell imaging systems.
    Type: Application
    Filed: January 16, 2017
    Publication date: July 13, 2017
    Inventors: Thomas E. HUGHES, Paul H. TEWSON, Anne Marie QUINN
  • Genetically encoded fluorescent sensors for detecting intracellular signalling through diacylglycerol pathways
    Patent number: 9547017
    Abstract: Described herein are novel fluorescent sensors for Diacyl Glycerol (DAG) and hosphatidylinositol 4,5-bisphosphate (PIP2) that are based on circularly permuted fluorescent proteins. These sensors use less visible spectrum than FRET-based sensors, produce robust changes in fluorescence, and can be combined with one another, or with other sensors, in a multiplex assay on standard fluorescent plate readers or live cell imaging systems.
    Type: Grant
    Filed: March 15, 2013
    Date of Patent: January 17, 2017
    Assignee: Montana Molecular LLC
    Inventors: Thomas E. Hughes, Paul H. Tewson, Anne Marie Quinn
  • GENETICALLY ENCODED FLUORESCENT SENSORS FOR DETECTING LIGAND BIAS AND INTRACELLULAR SIGNALING THROUGH cAMP PATHWAYS
    Publication number: 20160274109
    Abstract: Described herein are novel fluorescent sensors for cyclic adenosine monophosphate (cAMP) that are based on single fluorescent proteins. These sensors use less visible spectrum than FRET-based sensors, produce robust changes in fluorescence, and can be combined with one another, or with other sensors, in a multiplex assay on standard fluorescent plate readers or live cell imaging systems.
    Type: Application
    Filed: November 4, 2014
    Publication date: September 22, 2016
    Inventors: Thomas E. HUGHES, Paul H. TEWSON, Anne Marie QUINN
  • GENETICALLY ENCODED FLUORESCENT SENSORS FOR DETECTING INTRACELLULAR SIGNALLING THROUGH DIACYLGLYCEROL PATHWAYS
    Publication number: 20160003854
    Abstract: Described herein are novel fluorescent sensors for Diacyl Glycerol (DAG) and hosphatidylinositol 4,5-bisphosphate (PIP2) that are based on circularly permuted fluorescent proteins. These sensors use less visible spectrum than FRET-based sensors, produce robust changes in fluorescence, and can be combined with one another, or with other sensors, in amultiplex assay on standard fluorescent plate readers or live cell imaging systems.
    Type: Application
    Filed: March 15, 2013
    Publication date: January 7, 2016
    Inventors: Thomas E. Hughes, Paul H. Tewson, Anne Marie Quinn