Patents by Inventor Paul Hagerman

Paul Hagerman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Targeted rolling circle amplification
    Patent number: 9290800
    Abstract: Methods for amplifying a desired target region of a nucleic acid through rolling circle amplification with a strand-displacing polymerase are provided. Concatameric hairpin products are resolved with endonuclease digestion, and the resulting amplified product hairpins or fragments can be circularized and employed as templates in a subsequent round of amplification. The methods are effective for targeted amplification of even highly repetitive sequences. Compositions, kits, and systems related to or useful in the methods are also described.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: March 22, 2016
    Assignees: Pacific Biosciences of California, Inc., The Regents of the University of California
    Inventors: Stephen W. Turner, Thang Pham, Paul Hagerman
  • Targeted Rolling Circle Amplification
    Publication number: 20140295498
    Abstract: Methods for amplifying a desired target region of a nucleic acid through rolling circle amplification with a strand-displacing polymerase are provided. Concatameric hairpin products are resolved with endonuclease digestion, and the resulting amplified product hairpins or fragments can be circularized and employed as templates in a subsequent round of amplification. The methods are effective for targeted amplification of even highly repetitive sequences. Compositions, kits, and systems related to or useful in the methods are also described.
    Type: Application
    Filed: March 13, 2014
    Publication date: October 2, 2014
    Applicants: The Regents of the University of California, Pacific Biosciences of California, Inc.
    Inventors: Stephen W. Turner, Thang Pham, Paul Hagerman