Patents by Inventor Paul Hemmer
Paul Hemmer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11681133Abstract: A system having a macroscopic imager, a microscopic imager, and a stage for moving a substrate supporting ex-vivo tissue with respect to each of the imagers to enable the macroscopic imager to capture macroscopic images, and the microscopic imager to capture optically formed sectional microscopic images on or within the tissue, when presented to the tissue, via the optically transparent material of the substrate. A computer system controls movement of the stage, and receives the macroscopic and microscopic images. A display is provided for displaying the macroscopic and microscopic images when received by the computer system. The tissue is verified as being in an orientation at least substantially flush against the upper surface of the substrate by being in focus in displayed macroscopic images prior to imaging by the microscopic imager, and if needed, any portion of the tissue unfocused is manually positioned until desired tissue orientation is achieved.Type: GrantFiled: March 16, 2022Date of Patent: June 20, 2023Assignee: CALIBER IMAGING & DIAGNOSTICS, INC.Inventors: William J. Fox, Christopher C. Distasio, Allison L. Cramb, Paul Hemmer, Christopher E. Wagner, Keith A. Hadley, Elizabeth Kiefer
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Publication number: 20220206277Abstract: A system having a macroscopic imager, a microscopic imager, and a stage for moving a substrate supporting ex-vivo tissue with respect to each of the imagers to enable the macroscopic imager to capture macroscopic images, and the microscopic imager to capture optically formed sectional microscopic images on or within the tissue, when presented to the tissue, via the optically transparent material of the substrate. A computer system controls movement of the stage, and receives the macroscopic and microscopic images. A display is provided for displaying the macroscopic and microscopic images when received by the computer system. The tissue is verified as being in an orientation at least substantially flush against the upper surface of the substrate by being in focus in displayed macroscopic images prior to imaging by the microscopic imager, and if needed, any portion of the tissue unfocused is manually positioned until desired tissue orientation is achieved.Type: ApplicationFiled: March 16, 2022Publication date: June 30, 2022Inventors: WILLIAM J. FOX, CHRISTOPHER C. DISTASIO, ALLISON L. CRAMB, PAUL HEMMER, CHRISTOPHER E. WAGNER, KEITH A. HADLEY, ELIZABETH KIEFER
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Patent number: 11280990Abstract: A system having a macroscopic imager, a microscopic imager, and a stage for moving a substrate supporting ex-vivo tissue with respect to each of the imagers to enable the macroscopic imager to capture macroscopic images, and the microscopic imager to capture optically formed sectional microscopic images on or within the tissue, when presented to the tissue, via the optically transparent material of the substrate. A computer system controls movement of the stage, and receives the macroscopic and microscopic images. A display is provided for displaying the macroscopic and microscopic images when received by the computer system. The tissue is verified as being in an orientation at least substantially flush against the upper surface of the substrate by being in focus in displayed macroscopic images prior to imaging by the microscopic imager, and if needed, any portion of the tissue unfocused is manually positioned until desired tissue orientation is achieved.Type: GrantFiled: February 26, 2019Date of Patent: March 22, 2022Assignee: CALIBER IMAGING & DIAGNOSTICS, INC.Inventors: William J. Fox, Christopher C. Distasio, Allison L. Cramb, Paul Hemmer, Christopher E. Wagner, Keith A. Hadley, Elizabeth Kiefer
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Publication number: 20190265456Abstract: A system having a macroscopic imager, a microscopic imager, and a stage for moving a substrate supporting ex-vivo tissue with respect to each of the imagers to enable the macroscopic imager to capture macroscopic images, and the microscopic imager to capture optically formed sectional microscopic images on or within the tissue, when presented to the tissue, via the optically transparent material of the substrate. A computer system controls movement of the stage, and receives the macroscopic and microscopic images. A display is provided for displaying the macroscopic and microscopic images when received by the computer system. The tissue is verified as being in an orientation at least substantially flush against the upper surface of the substrate by being in focus in displayed macroscopic images prior to imaging by the microscopic imager, and if needed, any portion of the tissue unfocused is manually positioned until desired tissue orientation is achieved.Type: ApplicationFiled: February 26, 2019Publication date: August 29, 2019Inventors: WILLIAM J. FOX, CHRISTOPHER C. DISTASIO, ALLISON L. CRAMB, PAUL HEMMER, CHRISTOPHER E. WAGNER, KEITH A. HADLEY, ELIZABETH KIEFER
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Patent number: 9709791Abstract: Method and system for imaging tissue, including (i) causing a macroscopic image of a tissue surface to be displayed on a visual display; (ii) receiving a selection of at least one portion of the macroscopic image; (iii) causing a plurality of confocal images captured by a confocal imager at different depths in a portion of the tissue to be displayed; (iv) receiving a selection of at least one target depth image; and (v) for each selected target depth image, instructing the confocal imager to capture a plurality of additional images at different locations and at a common depth with the target depth image. A system for imaging tissue having a macroscopic display module; a first selection module; a confocal display module; a second selection module; and an instruction module for instructing a confocal imager to capture a plurality of images at different locations over a selected region of the tissue.Type: GrantFiled: August 9, 2013Date of Patent: July 18, 2017Assignee: LUCID, INC.Inventor: Paul Hemmer
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Publication number: 20140049632Abstract: Method and system for imaging tissue, including (i) causing a macroscopic image of a tissue surface to be displayed on a visual display; (ii) receiving a selection of at least one portion of the macroscopic image; (iii) causing a plurality of confocal images captured by a confocal imager at different depths in a portion of the tissue to be displayed; (iv) receiving a selection of at least one target depth image; and (v) for each selected target depth image, instructing the confocal imager to capture a plurality of additional images at different locations and at a common depth with the target depth image. A system for imaging tissue having a macroscopic display module; a first selection module; a confocal display module; a second selection module; and an instruction module for instructing a confocal imager to capture a plurality of images at different locations over a selected region of the tissue.Type: ApplicationFiled: August 9, 2013Publication date: February 20, 2014Applicant: Lucid, Inc.Inventor: Paul Hemmer
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Patent number: 7864996Abstract: A system for macroscopic and confocal imaging of tissue having a macroscopic imager for capturing a macroscopic image of the tissue's surface, a confocal imager for capturing one or more optically formed sectional microscopic images on or within tissue, a computer for receiving images from such imagers, and a tissue attachment device in which the macroscopic imager and confocal imager are each individually presented to the tissue utilizing the tissue attachment device in a predefined alignment, such that imaging locations of the confocal imager with respect to the tissue surface spatially correlate with macroscopic image. A user interface is operable on the computer to enable display of the macroscopic image on a display coupled to the computer, and to indicate a region within the macroscopic image associated with the field of view of the tissue imagable by the confocal imager.Type: GrantFiled: February 17, 2006Date of Patent: January 4, 2011Assignee: Lucid, Inc.Inventors: Paul Hemmer, Zachary M. Eastman, Jay M. Eastman, William J. Fox, James M. Zavislan
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Publication number: 20070206275Abstract: A system for macroscopic and confocal imaging of tissue having a macroscopic imager for capturing a macroscopic image of the tissue's surface, a confocal imager for capturing one or more optically formed sectional microscopic images on or within tissue, a computer for receiving images from such imagers, and a tissue attachment device in which the macroscopic imager and confocal imager are each individually presented to the tissue utilizing the tissue attachment device in a predefined alignment, such that imaging locations of the confocal imager with respect to the tissue surface spatially correlate with macroscopic image. A user interface is operable on the computer to enable display of the macroscopic image on a display coupled to the computer, and to indicate a region within the macroscopic image associated with the field of view of the tissue imagable by the confocal imager.Type: ApplicationFiled: February 17, 2006Publication date: September 6, 2007Inventors: Paul Hemmer, Zachary Eastman, Jay Eastman, William Fox, James Zavislan