Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Biological effects may include upregulating and downregulating inflammatory immune response molecules within a target tissue. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths.

Abstract: The present invention is directed to anti-PVRIG antibodies and stable liquid pharmaceutical formulations thereof. The present invention is directed to monotherapy and combination treatments with anti-PVRIG antibodies and anti-PD-1 antibodies, in particular nivolumab, using stable liquid pharmaceutical formulations thereof. The present invention also provides biomarkers for use in determining populations for treatment with anti-PVRIG antibodies and such biomarkers include, for example PVRIG and/or PVRL2 expression.

Abstract: A clamp apparatus is used for securing one end of a flexible sheet spanning under tension across a building opening relative to a perimeter beam along the edge of the building opening. The clamp apparatus has a C-shaped channel body having (i) a first flange with a threaded bore therein to receive a bolt defining a first clamping jaw and (ii) a second flange defining an opposing second clamping jaw, whereby the clamp apparatus clamps a perimeter mounted flange of the flexible sheet onto a beam flange of the perimeter beam. C-shaped stiffener plates are mounted externally on the channel body, spaced apart from one another along the length of the channel body in perpendicular relation to the length to reinforce the clamp such that the clamp is able to withstand high wind forces acting on the tensioned sheet.

Abstract: Illumination devices for impinging light on tissue, for example within a body cavity of a patient, to induce various biological effects are disclosed. Biological effects may include at least one of inactivating and/or inhibiting growth of one or more pathogens, upregulating a local immune response, increasing endogenous stores of nitric oxide, releasing nitric oxide from endogenous stores, and inducing an anti-inflammatory effect. Biological effects may include upregulating and downregulating inflammatory immune response molecules within a target tissue. Wavelengths of light are selected based on intended biological effects for one or more of targeted tissue types and targeted pathogens. Light treatments may provide multiple pathogenic biological effects, either with light of a single wavelength or with light having multiple wavelengths.

Abstract: In an embodiment, a method is performed by a middleware computing platform and includes maintaining an active user pool comprising a plurality of servicing users. The method also includes exposing a service request interface to a plurality of user-to-user service platforms. The plurality of user-to-user platforms provide independent computing environments that separately execute user-to-user service workflows for requesting users. The method further includes receiving, via the service request interface, a plurality of service requests each from one of the plurality of user-to-user service platforms. In addition, the method includes automatically assigning one or more of the plurality of service requests to a target servicing user of the plurality of servicing users based at least in part on information associated with the service request and availability of the target servicing user. The method also includes exposing a service provider interface to the target servicing user.

Abstract: Two sorghum maternal haploid inducer lines SMHI01 and SMHI02 are provided including seed, plants and plant parts thereof. Methods for producing sorghum haploid embryos using SMHI01 and SMHI02 are also provided. The sorghum haploid embryos produced as a result of the use of either maternal haploid inducer line SMHI01 or SMHI02 may be doubled to produce doubled haploid embryos, seeds, and plants as part of a sorghum breeding program.

Abstract: An apparatus including an inspection apparatus for inspecting an artefact, and a transfer mechanism for moving a pallet on which an artefact is located relative to the inspection apparatus so as to move the pallet to and from an inspection location, and further including at least one pallet lifter which can be actuated between a retracted and an extended configuration, configured such that when a pallet is at the inspection location the at least one pallet lifter can be actuated to its extended configuration so as to engage with and lift the pallet and thereby decouple the pallet from the transfer mechanism.

Abstract: A pallet loader for a positioning apparatus, including at least two pallet bays and at least one intermediate member, arranged such that at least two pallet bays are located on different sides of the intermediate member, such that at least one pallet can be driven i) from one pallet bay to another, and ii) from one pallet bay to a positioning apparatus, in which the apparatus includes cooperating guide features on the underside of the at least one pallet and on one or more of the intermediate member and pallet bays for guiding the pallet along a predetermined path and/or for controlling the rotational orientation of the pallet about a vertical axis, as the pallet moves across the intermediate member/pallet bay.

Abstract: Multiple designs, systems, methods and processes for control using electrical signals recorded from clinically paralyzed muscles and nerves are presented. The discomplete neural prosthesis system and method for clinically paralyzed humans utilizes a controller. The controller is adapted to receive a volitional electrical signal generated by the human that is manifest below the lesion that causes the clinical paralysis. The controller uses at least the volitional electrical signal to generate a control signal that is output back to a plant to change the state of the plant, which in one aspect is one or more of the user's paralyzed muscles to achieve a functional result or to devices in the environment around the user that are adapted to receive commands from the controller.

Abstract: Two sorghum maternal haploid inducer lines SMHI01 and SMHI02 are provided including seed, plants and plant parts thereof. Methods for producing sorghum haploid embryos using SMHI01 and SMHI02 are also provided. The sorghum haploid embryos produced as a result of the use of either maternal haploid inducer line SMHI01 or SMHI02 may be doubled to produce doubled haploid embryos, seeds, and plants as part of a sorghum breeding program.

Abstract: A coordinate positioning apparatus having a load bearing structure. The load bearing structure has at least one elongate corner piece providing at least two bearing surfaces, one on each side of the corner, for a carriage moveable along the load bearing structure, and at least one piece of sheet material which extends along the at least one elongate corner piece and provides at least one load bearing facet.

Abstract: Two Sorghum maternal haploid inducer lines SMHI01 and SMHI02 are provided including seed, plants and plant parts thereof. Methods for producing Sorghum haploid embryos using SMHI01 and SMHI02 are also provided. The Sorghum haploid embryos produced as a result of the use of either maternal haploid inducer line SMHI01 or SMHI02 may be doubled to produce doubled haploid embryos, seeds, and plants as part of a Sorghum breeding program.

Abstract: A positioning apparatus including a moveable member moveable along a bearing guideway in a first dimension, the moveable member including at a first end thereof at least first and second bearing members which are preloaded against corresponding first and second sides of a concave corner of the bearing guideway.

Abstract: A positioning apparatus, having first and second members relatively moveable in a substantially vertical degree of freedom. At least one energy conduit is mounted to at least one of the first and second members, which imparts a load on at least one of the members it is mounted to that varies dependent on the relative position of the first and second members. A compensatory member is configured to apply a load that varies, dependent on the relative position of the first and second members, inversely to the variation in load applied by the at least one energy conduit, so as to at least partially counteract the variation in load applied by the at least one energy conduit on said at least one of the members.

Abstract: A positioning apparatus comprising first and second relatively moveable members, and a linear motor comprising at least one elongate stator assembly and at least one armature assembly respectively mounted to the first and second moveable members for effecting relative movement of the first and second moveable members, configured so at to permit longitudinal expansion and/or contraction of the at least one elongate stator assembly and/or of the at least one armature assembly relative to its respective member.

Abstract: A coordinate positioning apparatus having a load bearing structure. The load bearing structure has at least one elongate corner piece providing at least two bearing surfaces, one on each side of the corner, for a carriage moveable along the load bearing structure, and at least one piece of sheet material which extends along the at least one elongate corner piece and provides at least one load bearing facet.

Abstract: Multiple designs, systems, methods and processes for control using electrical signals recorded from clinically paralyzed muscles and nerves are presented. The discomplete neural prosthesis system and method for clinically paralyzed humans utilizes a controller. The controller is adapted to receive a volitional electrical signal generated by the human that is manifest below the lesion that causes the clinical paralysis. The controller uses at least the volitional electrical signal to generate a control signal that is output back to a plant to change the state of the plant, which in one aspect is one or more of the user's paralyzed muscles to achieve a functional result or to devices in the environment around the user that are adapted to receive commands from the controller.

Abstract: A coordinate positioning apparatus comprising first and second relatively moveable bodies, at least the first body comprising at least one sheet or plate of material arranged to provide a load-bearing structure comprising a plurality of planar load-bearing members and on which at least one member is mounted to the first body via a mount which is coupled to at least three, non-parallel planar load-bearing members of the first body, such that the planes of said at least three non-parallel planar load-bearing members intersect each other at a common point.

Abstract: A positioning apparatus, having first and second members relatively moveable in a substantially vertical degree of freedom. At least one energy conduit is mounted to at least one of the first and second members, which imparts a load on at least one of the members it is mounted to that varies dependent on the relative position of the first and second members. A compensatory member is configured to apply a load that varies, dependent on the relative position of the first and second members, inversely to the variation in load applied by the at least one energy conduit, so as to at least partially counteract the variation in load applied by the at least one energy conduit on said at least one of the members.

Abstract: A coordinate positioning apparatus for inspecting an artefact. The coordinate positioning apparatus includes at least one moveable member moveable in at least one degree of freedom, and at least one motor and at least one bearing arrangement for facilitating said movement. At least a part of the at least one motor and/or at least one bearing arrangement are located inside a protective housing therefor. A ferromagnetic contamination trap comprising at least one magnet is provided and configured to attract and retain ferromagnetic contamination entering the protective housing.