Patents by Inventor Paul Isbester

Paul Isbester has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLYMORPHS OF HYDROCHLORIDE SALT OF 5-(3-(ETHYLSULFONYL)PHENYL)-3,8-DIMETHYL-N-(1-METHYLPIPERIDIN-4-YL)-9H-PYRIDO[2,3-B]INDOLE-7-CARBOXAMIDE AND METHODS OF USE THEREFOR
    Publication number: 20090270442
    Abstract: Polymorphic forms of the hydrochloride salt of 5-(3-(ethylsulfonyl)phenyl)-3,8-dimethyl-N-(1-methylpiperidin-4-yl)-9h-pyrido[2,3-b]indole-7-carboxamide (referred to herein as Compound 1) which has the formula: and compositions thereof, wherein the Compound 1 is present in one or more polymorphic forms. Also provided are novel methods for the preparation of the polymorphs of Compound 1, and kits and articles of manufacture of the compositions, and methods of using the compositions to treat various diseases.
    Type: Application
    Filed: April 13, 2009
    Publication date: October 29, 2009
    Applicant: TAKEDA PHARMACEUTICAL COMPANY LIMITED
    Inventors: Lauren Graham, Paul Isbester, Olga V. Lapina, Bingidimi I. Mobele, Grant J. Palmer, Karl Reineke, Jonathon S. Salsbury, Luckner Ulysse
  • DIPEPTIDYL PEPTIDASE INHIBITORS
    Publication number: 20080108808
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C?NR9; and each L, X, R1, R2, and R3 are as defined herein.
    Type: Application
    Filed: October 30, 2007
    Publication date: May 8, 2008
    Inventors: Jun Feng, Stephen Gwaltney, Jeffrey Stafford, Zhiyuan Zhang, Bruce Elder, Paul Isbester, Grant Palmer, Jonathon Salsbury, Luckner Ulysse
  • DIPEPTIDYL PEPTIDASE INHIBITORS
    Publication number: 20080108807
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C?NR9; and each L, X, R1, R2, and R3 are as defined herein.
    Type: Application
    Filed: October 30, 2007
    Publication date: May 8, 2008
    Inventors: Jun Feng, Stephen Gwaltney, Jeffrey Stafford, Zhiyuan Zhang, Bruce Elder, Paul Isbester, Grant Palmer, Jonathon Salsbury, Luckner Ulysse
  • POLYMORPHIC FORM OF FLUORO-7-(2,2,2-TRIFLUOROETHOXY) PHENOXATHIIN-10,10-DIOXIDE
    Publication number: 20080009542
    Abstract: Provided herein is a new form of 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathin 10,10-dioxide, which demonstrates higher stability relative to other forms of 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiin-10,10-dioxide. In particular, this new form affords less dosage critical administration of 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathin 10,10-dioxide relative to other forms. The new solid form of 3-fluoro-7-(2,2,2-trifluoroethoxy)phenoxathiin-10,10-dioxide has been determined and is provided herein.
    Type: Application
    Filed: July 5, 2007
    Publication date: January 10, 2008
    Applicant: CeNeRx BioPharma, Inc.
    Inventors: Elisabeth Brot, Daniel Keefe, Brian Haney, Nigel Metcalfe, Grant Palmer, Paul Isbester
  • DIPEPTIDYL PEPTIDASE INHIBITORS
    Publication number: 20080003283
    Abstract: Compounds are provided for use with DPP-IV of the formula: Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds; methods and intermediates useful for making the compounds; and methods of using said compounds.
    Type: Application
    Filed: August 7, 2007
    Publication date: January 3, 2008
    Applicant: TAKEDA PHARMACEUTICAL COMPANY, INC.
    Inventors: Jun Feng, Stephen Gwaltney, Jeffrey Stafford, Zhiyuan Zhang, Bruce Elder, Paul Isbester, Grant Palmer, Jonathan Salsbury, Luckner Ulysse
  • Catalytic hydrogenation of nitriles to produce capsaicinoid derivatives and amine compounds, and methods for purifying and obtaining the polymorphs thereof
    Publication number: 20060047171
    Abstract: Processes for preparing an amine compound by catalytically hydrogenating a precursor nitrile compound. In a particular aspect, the present hydrogenation process occurs in a dipolar organic solvent in the presence of a palladium/carbon catalyst and a strong anhydrous protic acid. In a further aspect, the preferred embodiment relates to a process for deprotecting a compound to produce an amine compound. In yet a further aspect, the preferred embodiment relates to amine products produced by the present processes. These amine products may be used for a variety of purposes.
    Type: Application
    Filed: August 27, 2004
    Publication date: March 2, 2006
    Inventors: Harold Meckler, Karl Popp, Bingidimi Mobele, Paul Isbester, Bruce Elder, Paul Vogt, Benjamin Littler, Stephen Eastham, David Reed, Luckner Ulysse, Michael Uttley
  • Dipeptidyl peptidase inhibitors
    Publication number: 20050261271
    Abstract: Compounds, pharmaceuticals, kits and methods are provided for use with DPP-IV and other S9 proteases that comprise a compound comprising: wherein M is N or CR4; Q1 and Q2 are each independently selected from the group consisting of CO, SO, SO2, and C?NR9; and each L, X, R1, R2, and R3 are as defined herein.
    Type: Application
    Filed: March 15, 2005
    Publication date: November 24, 2005
    Inventors: Jun Feng, Stephen Gwaltney, Jeffrey Stafford, Zhiyuan Zhang, Bruce Elder, Paul Isbester, Grant Palmer, Jonathon Salsbury, Luckner Ulysse