Abstract: Device and methods for detecting/quantifying a fluorescent taggant in a liquid sample. Generally, the liquid samples are fuels having low concentrations (measured in ppb) of a fluorescent taggant. The detection/quantification generates a predicted concentration of the fluorescent tagging compound using a process selected from the group of a multivariate process, a background subtraction process, or a combination of both. The invention addresses the detection of an adulteration of gasoline and diesel fuels.

Abstract: Apparatus and methods are provided for the imaging of structures in deep tissue within biological specimens, using spectral imaging to provide highly sensitive detection. By acquiring data that provides a plurality of images of the sample with different spectral weightings, and subsequent spectral analysis, light emission from a target compound is separated from autofluorescence in the sample. With the autofluorescence reduced or eliminated, an improved measurement of the target compound is obtained.

Abstract: A device detects multi-spectral imaging by using scan elements. The device may include an illumination module and a detection module to detect light scattered from an object illuminated by the illumination module. The device may also include an array of light sources to produce light at a plurality of different wavelengths, and create a line of illumination with each of the different wavelengths. The light detection may be applied to authenticate and validate documents, such as banknotes moving along a document conveyer.

Abstract: Device and methods for detecting/quantifying a fluorescent taggant in a liquid sample. Generally, the liquid samples are fuels having low concentrations (measured in ppb) of a fluorescent taggant. The detection/quantification generates a predicted concentration of the fluorescent tagging compound using a process selected from the group of a multivariate process, a background subtraction process, or a combination of both. The invention addresses the detection of an adulteration of gasoline and diesel fuels.

Abstract: The invention features a method including: (i) providing spectrally resolved information about light coming from different spatial locations in a sample comprising deep tissue in response to an illumination of the sample, wherein the light includes contributions from different components in the sample; (ii) decomposing the spectrally resolved information for each of at least some of the different spatial locations into contributions from spectral estimates associated with at least some of the components in the sample; and (iii) constructing a deep tissue image of the sample based on the decomposition to preferentially show a selected one of the components.

Abstract: The invention features a method including: (i) providing spectrally resolved information about light coming from different spatial locations in a sample comprising deep tissue in response to an illumination of the sample, wherein the light includes contributions from different components in the sample; (ii) decomposing the spectrally resolved information for each of at least some of the different spatial locations into contributions from spectral estimates associated with at least some of the components in the sample; and (iii) constructing a deep tissue image of the sample based on the decomposition to preferentially show a selected one of the components.

Abstract: A device detects multi-spectral imaging by using scan elements. The device may include an illumination module and a detection module to detect light scattered from an object illuminated by the illumination module. The device may also include an array of light sources to produce light at a plurality of different wavelengths, and create a line of illumination with each of the different wavelengths. The light detection may be applied to authenticate and validate documents, such as banknotes moving along a document conveyer.

Abstract: A device detects multi-spectral imaging by using scan elements. The device may include an illumination module and a detection module to detect light scattered from an object illuminated by the illumination module. The device may also include an array of light sources to produce light at a plurality of different wavelengths, and create a line of illumination with each of the different wavelengths. The light detection may be applied to authenticate and validate documents, such as banknotes moving along a document conveyer.

Abstract: The invention features a method including: (i) providing spectrally resolved information about light coming from different spatial locations in a sample comprising deep tissue in response to an illumination of the sample, wherein the light includes contributions from different components in the sample; (ii) decomposing the spectrally resolved information for each of at least some of the different spatial locations into contributions from spectral estimates associated with at least some of the components in the sample; and (iii) constructing a deep tissue image of the sample based on the decomposition to preferentially show a selected one of the components.

Abstract: The invention features a method including: (i) providing spectrally resolved information about light coming from different spatial locations in a sample comprising deep tissue in response to an illumination of the sample, wherein the light includes contributions from different components in the sample; (ii) decomposing the spectrally resolved information for each of at least some of the different spatial locations into contributions from spectral estimates associated with at least some of the components in the sample; and (iii) constructing a deep tissue image of the sample based on the decomposition to preferentially show a selected one of the components.

Abstract: A device detects multi-spectral imaging by using scan elements. The device may include an illumination module and a detection module to detect light scattered from an object illuminated by the illumination module. The device may also include an array of light sources to produce light at a plurality of different wavelengths, and create a line of illumination with each of the different wavelengths. The light detection may be applied to authenticate and validate documents, such as banknotes moving along a document conveyer.

Abstract: Apparatus and methods are provided for the imaging of structures in deep tissue within biological specimens, using spectral imaging to provide highly sensitive detection. By acquiring data that provides a plurality of images of the sample with different spectral weightings, and subsequent spectral analysis, light emission from a target compound is separated from autofluorescence in the sample. With the autofluorescence reduced or eliminated, an improved measurement of the target compound is obtained.

Abstract: A device detects multi-spectral imaging by using scan elements. The device may include an illumination module and a detection module to detect light scattered from an object illuminated by the illumination module. The device may also include an array of light sources to produce light at a plurality of different wavelengths, and create a line of illumination with each of the different wavelengths. The light detection may be applied to authenticate and validate documents, such as banknotes moving along a document conveyer.

Abstract: Apparatus and methods are provided for the imaging of structures in deep tissue within biological specimens, using spectral imaging to provide highly sensitive detection. By acquiring data that provides a plurality of images of the sample with different spectral weightings, and subsequent spectral analysis, light emission from a target compound is separated from autofluorescence in the sample. With the autofluorescence reduced or eliminated, an improved measurement of the target compound is obtained.

Abstract: The invention features a method including: (i) providing spectrally resolved information about light coming from different spatial locations in a sample comprising deep tissue in response to an illumination of the sample, wherein the light includes contributions from different components in the sample; (ii) decomposing the spectrally resolved information for each of at least some of the different spatial locations into contributions from spectral estimates associated with at least some of the components in the sample; and (iii) constructing a deep tissue image of the sample based on the decomposition to preferentially show a selected one of the components.

Abstract: A device detects multi-spectral imaging by using scan elements. The device may include an illumination module and a detection module to detect light scattered from an object illuminated by the illumination module. The device may also include an array of light sources to produce light at a plurality of different wavelengths, and create a line of illumination with each of the different wavelengths. The light detection may be applied to authenticate and validate documents, such as banknotes moving along a document conveyer.

Abstract: The invention features a method including: (i) providing spectrally resolved information about light coming from different spatial locations in a sample comprising deep tissue in response to an illumination of the sample, wherein the light includes contributions from different components in the sample; (ii) decomposing the spectrally resolved information for each of at least some of the different spatial locations into contributions from spectral estimates associated with at least some of the components in the sample; and (iii) constructing a deep tissue image of the sample based on the decomposition to preferentially show a selected one of the components.

Abstract: The invention features a method including: (i) providing spectrally resolved information about light coming from different spatial locations in a sample comprising deep tissue in response to an illumination of the sample, wherein the light includes contributions from different components in the sample; (ii) decomposing the spectrally resolved information for each of at least some of the different spatial locations into contributions from spectral estimates associated with at least some of the components in the sample; and (iii) constructing a deep tissue image of the sample based on the decomposition to preferentially show a selected one of the components.

Abstract: In some embodiments, the present disclosure is directed to a multi-modal, scanning, confocal, adaptive-optic macroscope system and related methods of use. Embodiments of the present disclosure improve upon existing photodynamic therapy methods and compete with more invasive oncology procedures (such as surgery, radiation, and/or chemotherapy) by providing deeper light penetration within the human body, giving medical personnel the ability to treat forms of cancer previously untreatable with existing photodynamic therapies, and with less damage to healthy tissue than current procedures. Embodiments of the present disclosure may be used for other medical purposes including internal artery and vein cauterizing (photo-coagulation), laser pulse induced sonication for dissolving kidney stones, removal of birth marks or tattoos, and/or for photo-biostimulation.

Abstract: Apparatus and methods are provided for the imaging of structures in deep tissue within biological specimens, using spectral imaging to provide highly sensitive detection. By acquiring data that provides a plurality of images of the sample with different spectral weightings, and subsequent spectral analysis, light emission from a target compound is separated from autofluorescence in the sample. With the autofluorescence reduced or eliminated, an improved measurement of the target compound is obtained.