Abstract: The invention includes compositions comprising substantially purified pyrroloquinoline quinone, that are useful in methods for the treatment and prevention of cardiac injury caused by hypoxia or ischemia. The invention also includes methods for the treatment and prevention of cardiac injury comprising contacting a composition of the invention with a human patient.

Abstract: Disclosed are methods of treating subjects having conditions related to angiogenesis including administering an effective amount of a polymeric form of thyroid hormone, or an antagonist thereof, to promote or inhibit angiogenesis in the subject. Compositions of the polymeric forms of thyroid hormone, or thyroid hormone analogs, are also disclosed.

Abstract: The invention includes composition comprising substantially purified pyrroloquinoline quinone, that are useful in methods for the treatment and prevention of cardiac injury caused by hypoxia or ischemia. The invention also includes methods for the treatment and prevention of cardiac injury comprising contacting a compression of the invention with a human patient.

Abstract: The invention includes composition comprising substantially purified pyrroloquinoline quinone, that are useful in methods for the treatment and prevention of cardiac injury caused by hypoxia or ischemia. The invention also includes methods for the treatment and prevention of cardiac injury comprising contacting a compression of the invention with a human patient.

Abstract: A method and test kit for providing contraceptive advice during the human ovulation cycle, involving simply the measurement of urinary lutenising hormone (LH) concentration on a daily basis during the early phase of the cycle until the LH surge indicative of ovulation is detected, together with calender means to advise the user to abstain from unprotected intercourse during a time interval commencing not later than a predetermined first day of LH testing and ending at least 2 days following the day of LH surge detection.

Abstract: A call related information detector/receiver system which is capable of downloading call related information received at that device to another call related information detector/receiver system remote from the system which initially received the call related information, back over the telephone line. Thus, a remote user while away from the home or office can receive and synchronize call related information at a system other than the one which initially received the call related information. Thus, a remote user can update a local call related information system and review past callers to their home or business telephone at their leisure. Upon establishment of a telephone call between customer premises equipment respectively associated with the two relevant call related information detector/receiver systems, a remote call related information system will request download of call related information logged from another call related information system using the established telephone call.

Abstract: A method of monitoring the status of a current ovulation cycle of an individual human female subject, involving testing of the body fluid concentration of an analyte of significance in relation to the status of the ovulation cycle, such as urinary E3G, during at least part of the pre-ovulation phase of the current ovulation cycle of the individual subject, and identification from the results of such testing an analyte concentration change indicative of imminent ovulation, relative to an analyte concentration reference value that has been adapted to the individual human subject on the basis of analyte concentration test data obtained from the individual human subject during one or more previous ovulation cycles.

Abstract: A multivalent antigen-binding protein comprises a first polypeptide comprising, in series, three or more variable domains of an antibody heavy chain and a second polypeptide comprising, in series, three of more variable domains of an antibody light chain, said first and second polypeptides being linked by association of the respective heavy chain and light chain variable domains, each associated variable domain pair forming an antigen binding site. Methods for their production and uses thereof, in particular for therapeutic and diagnostic applications, are disclosed.

Abstract: A method of monitoring the status of a current ovulation cycle of an individual human female subject, involving testing of the body fluid concentration of an analyte of significance in relation to the status of the ovulation cycle, such as urinary E3G, during at least part of the pre-ovulation phase of the current ovulation cycle of the individual subject, and identification from the results of such testing an analyte concentration change indicative of imminent ovulation, relative to an analyte concentration reference value that has been adapted to the individual human subject on the basis of analyte concentration test data obtained from the individual human subject during one or more previous ovulation cycles.

Abstract: Apparatus and methods for adaptively, reliably, and accurately measuring the frequency of an alerting or other signaling tone. A tone detector measures the frequency of a tone (continuous or pulsed) with a high degree of accuracy (e.g., to within 1 part in 10,000). Two lower order or smaller DFTs measure the energy level in two separate but intersecting frequency ranges. A simple ratio is determined from the relative energy measured from discrete Fourier transforms relating to each of the two separate frequency ranges, and an actual measured frequency is determined.

Abstract: Improved affinity purification media are provided by the use of small specific binding agents, especially Fv antibody fragments or single domain antibody fragments, immobilised on porous carriers having pore sizes in the range 30-1000 angstroms, preferably 30-300 angstroms. Silica is a preferred carrier. The small fragments are able to penetrate the pores and maximise the effective surface area of the carrier, and the microporous silica is sufficiently robust to be used at high pressure, so enabling the speed and/or throughput of a purification procedure to be increased.

Abstract: A process for carrying out a specific binding assay by reacting (a) a sample under assay for the possible presence of a substance being tested for, (b) a specific binding partner for the substance being tested for, immobilised on a solid support, and (c) a specific binding partner for the substance being tested for which is conjugated to a detectable marker, to thereby form a complex by reacting between whatever quantities are present of the substance being tested for in (a) with reagents (b) and (c). The marker is immobilised to the support via the substance being tested for, and is detected or assayed as an index of the quantity present in the sample (a) of any of the substance. The reaction ingredients (a), (b) and (c) are all mixed in a single step for reaction in a single reaction liquid.

Abstract: An antibody fragment able to bind to a target site is prolonged by an additional peptide. The Therapeutic agent is bound to this peptide or means are provided to bring about such binding. The antibody fragment and possibly also the therapeutic agent are included in a product so that binding to the target site delivers the therapeutic agent to the vicinity. The product may for example be for dental care, such as a toothpaste or mouthwash and the antibody fragment may then bind to a component of dental plaque.

Abstract: A method of monitoring the status of a current ovulation cycle of an individual human female subject, involving testing of the body fluid concentration of an analyte of significance in relation to the status of the ovulation cycle, such as urinary E3G, during at least part of the pre-ovulation phase of the current ovulation cycle of the individual subject, and identification from the results of such testing an analyte concentration change indicative of imminent ovulation, relative to an analyte concentration reference value that has been adapted to the individual human subject on the basis of analyte concentration test data obtained from the individual human subject during one or more previous ovulation cycles.

Abstract: An apparatus for electrical discharge machining (EDM) is disclosed having a housing and a workpiece support assembly secured to the housing for holding a workpiece in a predetermined location. An EDM electrode is attached to the housing for performing the EDM machining. A tank assembly is also attached to the housing and movable between a machining position and a retracted position. In the machining position, the tank assembly encompasses a workpiece secured to the workpiece support area and filled with a dielectric fluid necessary for the EDM machining process. In its retracted position, the tank assembly is spaced away from the workpiece to facilitate access to the workpiece for removal of the finished workpiece and reattachment of a new workpiece in preparation for the next EDM machining operation.

Abstract: A completed green tire is automatically released from a tire assembly drum and transported by automated holders to a discharge station, where an unloading track is positioned beneath the green tire. The holders include grips at the ends of reciprocable arms, arranged so the grips engage the periphery of the green tire at diametrically opposite points, which are on a line rotated somewhat from vertical with the bottom of such line away from the unloading track. Thus as the grips release the green tire, it rolls by gravity on its circular periphery onto the track mechanism, and passes to a discharge conveying system which can take the complete green tires to a vulcanizing and molding operation.

Abstract: A composition useful in oral immunisation of animals such as poultry comprises dry free-flowing particles each consisting of a solid beadlet of lipid-continuous emulsion containing from about 25% to about 50% by weight water in a lipid, such as hardened palm kernel oil, having a slip point in the range 35.degree. to 45.degree. C., each beadlet having an average diameter of about 2 to 3 millimeters and containing at least 1 viable encysted protozoan, such as a sporulated oocyst of a species of coccidium infective to poultry, each beadlet having a protective coating of animal feed, cement and/or gypsum, the protective coating having an average thickness of about 0.2 to 2 mm.

Abstract: An immunoassay for an analyte is disclosed in which (a) sample, (b) an immobilized specific binding partner for the analyte and (c) the specific binding partner for the analyte conjugated to a detectable marker are reacted together in a single step. Competitive interference of the reagents is avoided by using reagent (c) in a slow-release form as a glaze coated on a surface in contact with the reaction liquid.

Abstract: Aqueous concentrates intended for addition to nutrient material in the manufacture of feedstuffs for poultry are provided consisting essentially of water and from about 1000 to about 1,000,000 viable sporulated oocysts of at least one species of coccidia to which poultry are susceptible and at least one edible thickening agent which facilitates the mixing of the oocysts into feedstuff without destructive frictional heat.

Abstract: Essentially solid free-flowing pre-mixes and aqueous concentrates intended for addition to nutrient material in the manufacture of feedstuffs for poultry are provided consisting essentially of from about 1000 to about 1,000,000 viable sporulated oocysts of at least one species of coccidia to which poultry are susceptible and at least one edible thickening agent.