Patents by Inventor Paul J. Gilbert
Paul J. Gilbert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240082241Abstract: Compositions and methods for the induction of cell death, for example, cancer cell death. Combinations of compounds and related methods of use are disclosed, including the use of compounds in therapy for the treatment of cancer and selective induction of apoptosis in cells. The disclosed drug combinations can have lower neurotoxicity effects than other cancer therapies that achieve the same or similar therapeutic effect.Type: ApplicationFiled: November 21, 2023Publication date: March 14, 2024Applicants: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS, VANQUISH ONCOLOGY, INC., THE JOHNS HOPKINS UNIVERSITYInventors: Paul J. HERGENROTHER, Rachel C. BOTHAM, Timothy M. FAN, Mark J. GILBERT, Michael K. HANDLEY, Avadhut JOSHI, Gregory J. RIGGINS, Theodore M. TARASOW
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Publication number: 20230044222Abstract: An apparatus comprises a diffuser, a connection tube section forming a tubular fluid passage, a first indicating element section that indicates a measurement related to a body fluid disposed between a distal end and the connection tube section, a second indicating element section that indicates that the first indicating element section is suitable for use, and a housing having a generally tubular body. The diffuser is at least partially disposed in the generally tubular body. A fluid chamber adapted to receive fluid is cooperatively defined by the housing and the diffuser. The first indicating element section is visibly disposed in a first section of the housing. The second indicating element section is disposed within the fluid chamber. A micro-needle collector having pipettes to draw the fluid from a source to the distal end is attachable to the distal end.Type: ApplicationFiled: October 24, 2022Publication date: February 9, 2023Inventor: Paul J. Gilbert
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Publication number: 20230045755Abstract: An apparatus comprises a diffuser, a connection tube section forming a tubular fluid passage, a first indicating element section that indicates a measurement related to a body fluid disposed between a distal end and the connection tube section, a second indicating element section that indicates that the first indicating element section is suitable for use, and a housing having a generally tubular body. The diffuser is at least partially disposed in the generally tubular body. A fluid chamber adapted to receive fluid is cooperatively defined by the housing and the diffuser. The first indicating element section is visibly disposed in a first section of the housing. The second indicating element section is disposed within the fluid chamber. A micro-needle collector to draw the fluid from a source to the distal end is attachable to the distal end.Type: ApplicationFiled: October 24, 2022Publication date: February 9, 2023Inventor: Paul J Gilbert
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Patent number: 9658125Abstract: A fluid characteristic indicator for measuring and indicating a characteristic of body fluid from a medical or veterinary patient has a tubular housing with suction and fluid inlet ports at opposite ends and a fluid characteristic indicating element disposed within. A diffuser supports the indicating element and has at least one fluid channel to direct fluid toward the indicating element. The fluid channel may be formed as a spiral or helix, or as a plurality of longitudinal fluid channels. The housing and the diffuser may have additional structures forming channels that cooperatively direct fluid toward the indicating element. The diffuser may occupy nearly all the interior volume of the housing. Control of the fluid flow may make exposure and saturation of the indicator more accurate, avoid spurious indications due to the color of the fluid itself, and reduce the amount of fluid sample needed to obtain an indication or measurement.Type: GrantFiled: December 12, 2014Date of Patent: May 23, 2017Assignee: Right BiometricsInventors: Paul J. Gilbert, Rafal Chudzik
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Patent number: 9173602Abstract: An apparatus comprises a detection indicator, a housing, and an exoskeleton in which the housing nests. The detection indicator is configured to furnish a visual indication upon contact with a fluid responsive to a characteristic of the fluid. The housing comprises an interior chamber configured to receive the fluid and to provide contact between the fluid and the detection indicator. The housing is configured to removably engage a conduit coupled to a source of a fluid sample, which may be a lumen inserted into a patient to receive fluid therefrom. In methods for use with the apparatus, a sample is collected, a characteristic is measured by the apparatus, and the apparatus is disconnected so as to avoid leakage of the sample and exposure of personnel.Type: GrantFiled: August 20, 2012Date of Patent: November 3, 2015Inventor: Paul J. Gilbert
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Publication number: 20150168244Abstract: A fluid characteristic indicator for measuring and indicating a characteristic of a body fluid from a medical or veterinary patient has a generally tubular housing with a suction port at a proximal end and a fluid inlet port at the distal end. An fluid characteristic indicating element is disposed in the housing. A diffuser is provided in the housing to support the indicating element and direct fluid from the inlet port toward the indicating element. The diffuser has at least one fluid channel to direct fluid toward the indicating element. The fluid channel may take the form of a spiral or helix. Alternatively, the diffuser may have a plurality of longitudinal fluid channels. the housing and the diffuser may have additional structures forming channels that cooperatively direct fluid toward the indicating element. The diffuser and may occupy nearly all the interior volume of the housing.Type: ApplicationFiled: December 12, 2014Publication date: June 18, 2015Inventors: Paul J. Gilbert, Rafal Chudzik
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Publication number: 20120316415Abstract: An apparatus comprises a detection indicator, a housing, and an exoskeleton in which the housing nests. The detection indicator is configured to furnish a visual indication upon contact with a fluid responsive to a characteristic of the fluid. The housing comprises an interior chamber configured to receive the fluid and to provide contact between the fluid and the detection indicator. The housing is configured to removably engage a conduit coupled to a source of a fluid sample, which may be a lumen inserted into a patient to receive fluid therefrom. In methods for use with the apparatus, a sample is collected, a characteristic is measured by the apparatus, and the apparatus is disconnected so as to avoid leakage of the sample and exposure of personnel.Type: ApplicationFiled: August 20, 2012Publication date: December 13, 2012Inventor: Paul J Gilbert
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Publication number: 20110077495Abstract: An apparatus comprises a detection indicator and a housing. The detection indicator is configured to change from a first visual indication to a second visual indication upon contact with a fluid based on a characteristic of the fluid. The housing comprises an interior chamber configured to receive the fluid and to provide contact between the fluid and the detection indicator. The housing is configured to removably engage a lumen inserted into a patient to receive the fluid from the patient through the lumen.Type: ApplicationFiled: October 29, 2010Publication date: March 31, 2011Inventor: Paul J. Gilbert
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Publication number: 20100241104Abstract: A nasogastric tube insertion system comprises a nasogastric tube, a guide element, and an inserter element. The inserter element has a slim, elongate main body, a handle attached to the body, and an anatomically curved insertion section. The guide element comprises a swallowable weight attached to a cord, string, monofilament line, tube, or other similar line. The swallowable weight may be ablative in the presence of stomach fluids or may be deflated to allow the guide element to be removed while the nasogastric tube remains in place. The inserter element is inserted through the patient's nasal passages and optionally into the oropharynx. The weight is released and the patient swallows it into the stomach. The guide element is threaded through the guide element retaining structure, and the nasogastric tube is safely inserted along the guide element into the patient's stomach.Type: ApplicationFiled: April 19, 2010Publication date: September 23, 2010Inventor: Paul J. Gilbert
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Patent number: 7740620Abstract: A nasogastric tube insertion system comprises a nasogastric tube, a guide element, and an inserter element. The inserter element has a slim, elongate main body, a handle attached to the body, and an anatomically curved insertion section. The guide element comprises a swallowable weight attached to a cord, string, monofilament line, or other similar line. The nasogastric tube may be a nasogastric feeding tube and comprises a tube having one or more interior bores or lumina and a guide element capture structure. In use, the swallowable weight is placed onto the end of the inserter element. The inserter element is inserted through the patient's nasal passages and optionally into the oropharynx. The weight is released and the patient swallows it into the stomach. The guide element is threaded through the guide element retaining structure, and the nasogastric tube is safely inserted along the guide element into the patient's stomach. The tube and guide element are removed together when no longer needed.Type: GrantFiled: October 10, 2006Date of Patent: June 22, 2010Inventors: Paul J. Gilbert, Robert P. Gilbert
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Patent number: 7699818Abstract: A nasogastric tube insertion system comprises a nasogastric tube, a guide element, and an inserter element. The inserter element has a slim, elongate main body, a handle attached to the body, and an anatomically curved insertion section. The guide element comprises a swallowable weight attached to a cord, string, monofilament line, tube, or other similar line. The swallowable weight may be ablative in the presence of stomach fluids or may be deflated to allow the guide element to be removed while the nasogastric tube remains in place. The inserter element is inserted through the patient's nasal passages and optionally into the oropharynx. The weight is released and the patient swallows it into the stomach. The guide element is threaded through the guide element retaining structure, and the nasogastric tube is safely inserted along the guide element into the patient's stomach.Type: GrantFiled: June 27, 2007Date of Patent: April 20, 2010Inventor: Paul J. Gilbert
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Patent number: 7695459Abstract: A nasogastric tube insertion system comprises a nasogastric tube, a guide element, and an inserter element. The inserter element has a slim, elongate main body, a handle attached to the body, and an anatomically curved insertion section. The guide element comprises a swallowable weight attached to a cord, string, monofilament line, or other similar line. The nasogastric tube comprises a tube having one or more interior bores or lumina and a guide element capture structure. In use, the swallowable weight is placed onto the end of the inserter element. The inserter element is inserted through the patient's nasal passages and optionally into the oropharynx. The weight is released and the patient swallows it into the stomach. The guide element is threaded through the guide element retaining structure, and the nasogastric tube is safely inserted along the guide element into the patient's stomach. The tube and guide element are removed together when no longer needed.Type: GrantFiled: February 3, 2006Date of Patent: April 13, 2010Inventors: Paul J. Gilbert, Robert P. Gilbert