Abstract: Antibodies that bind the tumor (T) antigen of the Merkel cell polyomavirus are disclosed. The antibodies can be use used in cell-based immunotherapies, antibody-based therapies, diagnostics, and detection assays, among other uses.

Abstract: Provided is a compound of formula I, or pharmaceutically acceptable salt or solvate thereof, as defined herein for use in the treatment or prevention of a Dirofilaria infection in a mammal, The compounds are also for use in the treatment or prevention of diseases or conditions caused by a Dirofilaria infection in a mammal. Also described are corresponding methods of treating or preventing a Dirofilaria infection in a mammal.

Abstract: A device for performing micro-operations on a vesicular target, comprising an injection pipette (27); a barrel assembly (9); and an outer assembly (1). The injection pipette, barrel assembly, and outer assembly being designed and situated in relation to each other such that an axial vacuum passage is created between the injection pipette and the barrel assembly, and a radial vacuum passage is created between the barrel assembly and outer assembly, and such vacuum passages are isolated from each other and from atmospheric pressure (FIG. 8). The device also comprises a means of advancing and withdrawing the distal end of the barrel assembly in relation to the distal end of the outer assembly so as to create a holding well (31) and a means of advancing the pipette into, and withdrawing the pipette from, a vesicular object.

Abstract: A device for removing material from a vesicular object, said device being a pipette having a sealed tip at its distal end and an aperture whereby the distal tip of the device is inserted into the target object, the aperture aligned with the material to be removed from the object, vacuum applied to the inside of the device, such vacuum drawing the material into the aperture, and the device being removed from the object in such a manner as to cut or otherwise separate the material in the pipette from the object, the material remaining in the pipette, while leaving the object undamaged.

Abstract: A method for removing material from a vesicular object by securing the object, penetrating the object with a pipette, such pipette having a sealed distal tip and an aperture, advancing said pipette into the object in such a manner as to place the aperture directly adjacent to the material to be removed from the object, applying vacuum inside the pipette thereby drawing the material to be removed from the object into the pipette, and removing the pipette from the object in such a manner as to cut or otherwise separate the material in the pipette from the object thereby leaving the material removed from the object in the pipette while leaving the object undamaged.

Abstract: A method for removing material from a vesicular object by securing the object, penetrating the object with a pipette, such pipette having a sealed distal tip and an aperture, advancing said pipette into the object in such a manner as to place the aperture directly adjacent to the material to be removed from the object, applying vacuum inside the pipette thereby drawing the material to be removed from the object into the pipette, and removing the pipette from the object in such a manner as to cut or otherwise separate the material in the pipette from the object thereby leaving the material removed from the object in the pipette while leaving the object undamaged.

Abstract: A particulate detector (10) comprises a radiation source (12) arranged to emit radiation in at least first and second predetermined wavebands towards a sampling region (18) suspected of containing particulates, and a detection element (14), shielded from the radiation source (12), and arranged to detect radiation from the sampling region (18) at least first and second instances. The radiation source (12) is such that the emissions in the wavebands temporarily overlap. The detector is such that, at the instances at which the radiation is detected, the relative contributions from the emissions in each predetermined waveband are distinguishable, thereby allowing characteristics of the particulates to be determined. The radiation source (12) may comprise a light emitting diode (24).

Abstract: A device for performing micro-operations on a vesicular target, comprising an injection pipette (27); a barrel assembly (9); and an outer assembly (1). The injection pipette, barrel assembly, and outer assembly being designed and situated in relation to each other such that an axial vacuum passage is created between the injection pipette and the barrel assembly, and a radial vacuum passage is created between the barrel assembly and outer assembly, and such vacuum passages are isolated from each other and from atmospheric pressure (FIG. 8). The device also comprises a means of advancing and withdrawing the distal end of the barrel assembly in relation to the distal end of the outer assembly so as to create a holding well (31) and a means of advancing the pipette into, and withdrawing the pipette from, a vesicular object.

Abstract: A method for performing micro-operations on a vesicular object comprising securing the vesicular object by applying negative pressure in a radial vacuum passage; advancing a pipette into the vesicular object through an axial vacuum passage; ensuring that the axial vacuum passage and the radial vacuum passage are not in fluid contact with each other; controlling the negative pressure in both axial and radial vacuum passages, and the pressure or vacuum in the pipette separately; whereby allowing the simultaneous holding of the vesicular object by applying negative pressure in the radial vacuum passage; injection into or aspiration from the vesicular object via the pipette; and aspiration from the vesicular object by applying negative pressure in the axial vacuum passage.

Abstract: A particulate detector (10) comprises a radiation source (12) arranged to emit radiation in at least first and second predetermined wavebands towards a sampling region (18) suspected of containing particulates, and a detection element (14), shielded from the radiation source (12), and arranged to detect radiation from the sampling region (18) at least first and second instances. The radiation source (12) is such that the emissions in the wavebands temporarily overlap. The detector is such that, at the instances at which the radiation is detected, the relative contributions from the emissions in each predetermined waveband are distinguishable, thereby allowing characteristics of the particulates to be determined. The radiation source (12) may comprise a light emitting diode (24).

Abstract: A detector for smoke, heat or the like, which has test function circuitry capable of initiating verification of the detector operation, including testing of a communication path between the detector and a central control unit. The test is actuated on receipt of a signal initiated at the detector, which indicates success by illuminating the detector's LED. An operator is able to initiate the test by means of a laser pointer.

Abstract: A detector for smoke, heat or the like, which has test function circuitry capable of initiating verification of the detector operation, including testing of a communication path between the detector and a central control unit. The test is actuated on receipt of a signal initiated at the detector, which indicates success by illuminating the detector's LED. An operator is able to initiate the test by means of a laser pointer.

Abstract: A tape dispenser folds over an edge portion of a strip of masking tape while the masking tape is being dispensed therefrom. The masking tape may then be used to effect feathering or blending of paint sprayed on a desired surface, such as an automobile body or the like. The tape dispenser has a holder for holding at least one roll of masking tape and also has a tape guide configured to cause the masking tape dispensed from the tape holder to fold over and to adhere to itself when the masking tape is manually pulled against the tape guide.

Abstract: A polymer lined capillary column for use in gas chromotagraphy has a thin layer of ethoxycarbonyl substituted polyphenylene resin solvent deposited and uniformly coated on the interior surface of the base column as a support for a stationary phase, the resin coated column further including a separate stationary phase with the resin.

Abstract: A cabin pressure control system for an aircraft in which the controller provides control signals to an outflow valve by way of a pneumatic amplifier relay means, has the memory or rate chamber of the controller providing the pneumatic signal to the relay instead of the usual case where the signal comes from the reference pressure chamber. Any one of several forms of relays may be used in this novel system. One form of relay includes a feedback signal from the outflow valve.

Abstract: An in-line pump device having a hollow, power shaft formed with an internal rotary chamber having an impeller vane assembly mounted therein to pump a fluid therethrough, the power being supplied by a motor positioned substantially about the power shaft.