Abstract: Provided is a compound of formula I, or pharmaceutically acceptable salt or solvate thereof, as defined herein for use in the treatment or prevention of a Dirofilaria infection in a mammal, The compounds are also for use in the treatment or prevention of diseases or conditions caused by a Dirofilaria infection in a mammal. Also described are corresponding methods of treating or preventing a Dirofilaria infection in a mammal.

Abstract: Known “good” reference lines are provided for scope leveling using a reference device support platform attached to a rifle such that the reference device support platform first surface is parallel to rifle's horizontal bore center line and perpendicular to rifle's vertical bore center line. An alignment reference device, such as a laser leveling device, is then placed on the reference device support platform. When the alignment reference device is so placed, a horizontal axis of the alignment reference device will be parallel to the rifle's horizontal bore center line and a vertical axis of the alignment reference device will be perpendicular to the rifle's horizontal bore center line. Consequently, when vertical and/or horizontal reference lines are generated by the alignment reference device they are known “good” reference lines to be lined up with the scope's stadia lines.

Abstract: A split folding handle hatchet is disclosed that in a first position can be used as a hatchet and in a second position can be used as an Eskimo ulu-type of scraper. The hatchet shank is securely held by unique raised surfaces on the inside of each handle portion when the handle is gripped by the woodsman.