Abstract: Disclosed herein are antibacterial compounds that accumulate in Gram-negative bacteria, methods of preparing the compounds, and methods of using the compounds to inhibit or kill microbes, and methods of treating microbial infections, such as Gram-negative bacterial infections. Compounds selected for conversion to potential Gram-negative antibacterial compounds were identified based on compounds having low globularity and low flexibility. Amine substituents were then strategically added to the selected compounds to provide compounds having antibacterial activity against Gram-negative bacteria.

Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.

Abstract: A photosensitizer formulation can be disposed on or in a mesh; net; netting; screen; curtain of strands, fibers, or monofilaments; substrate, personal protective gear, mask, or any other suitable object. The photosensitizer formulation, when in contact with molecular oxygen and activated by light or ultrasound, produces microbicidal singlet oxygen. A variety of different arrangements and applications are described. For example, an air flow device may also be included to generate a flow of air through or over the photosensitizer formulation. A fluorescent formulation may be included to monitor photobleaching. The photosensitizer formulation may be disposed in a concentration gradient to generate antigenic particles by damaging or destroying microbes.

Abstract: A computer-implemented method is provided for detecting actionable transaction risks. The method includes grouping an inbound event related to a transaction with a target event group and determining an actionable group of events that are deemed high risk and a non-actionable group of non-actionable events that are deemed low risk. The method also includes evaluating the target event group relative to the actionable and non-actionable groups of events. This includes computing a first distance between the target event group and the non-actionable group and a second distance between the target event group and actionable group. The first distance is compared with the second distance to determine if the target event group, including the inbound event, is closer to the actionable group or to the nonactionable group.

Abstract: Embodiments provide systems, methods, and computer program products to generate a network topology. Internet Protocol (IP) addresses may be collected that immediately precede a first IP address in a set of IP-address-sequences to obtain a first set of previous-hop IP addresses, where each IP-address-sequence in the set of IP-address-sequences comprises a sequence of IP addresses traversed by at least one packet. Next, each IP address in the first set of previous-hop IP addresses may be associated with a first logical node in the network topology.

Abstract: Embodiments provide systems, methods, and computer program products for inferring node and link information from traceroute data in order to generate topology information. A system receives traceroute data for a data packet that traverses a path from a source to a destination. The system infers port types for the addresses in the traceroute data and groups subsets of the addresses in the traceroute data into logical nodes based on neighbor relationships demonstrated in backward and forward neighbors sets. The system then generates node and link information based on the inferred and grouped information.

Abstract: Embodiments provide systems, methods, and computer program products for inferring node and link information from traceroute data in order to generate topology information. A system receives traceroute data for a data packet that traverses a path from a source to a destination. The system infers port types for the addresses in the traceroute data and groups subsets of the addresses in the traceroute data into logical nodes based on neighbor relationships demonstrated in backward and forward neighbors sets. The system then generates node and link information based on the inferred and grouped information.

Abstract: A method for developing a business plan for a business entity includes providing a value indicating a predicted amount of business entity sales for one or more products. The method further includes, based on the provided value, determining, for each of one or more sales sources, an expected amount of opportunities necessary to generate the predicted amount of business entity sales. The method additionally includes storing a respective indicator of the predicted amount of opportunities for each of the one or more sales sources, and using the one or more respective indicators to develop a business plan.

Abstract: A method for evaluating opportunities in a sales funnel management system is disclosed. The method includes selecting one or more filters from one or more respective filter categories. The method further includes using the selected one or more filters to filter data provided to a data file, and providing actual opportunity data to the data file for each of one or more sales stages for each of one or more periods of time, based on the selected one or more filters. The method further includes displaying at least a portion of the provided actual opportunity data, and comparing the actual opportunity data to desired opportunity data to indicate whether a business entity is meeting its business plan.

Abstract: Usage of network resources on a communications network is controlled by creating one or more packet rules for analyzing packets received at one or more devices of the communications network, each rule including a condition and action to be taken if a packet received at a device satisfies the condition, and creating one or more service abstractions, each service abstraction representing a named set of one or more of the packet rules. Further, one or more role abstractions may be created, each role abstraction representing a role of a user with respect to the communications network, and each role abstraction including a set of one more packet rules, and possibly one or more service abstractions. These role abstractions and service abstractions may be stored and distributed to network devices on the communications network.