Patents by Inventor Paul L. DeAngelis

Paul L. DeAngelis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HEPAROSAN POLYMERS AND METHODS OF MAKING AND USING SAME FOR THE ENHANCEMENT OF THERPEUTICS
    Publication number: 20210275679
    Abstract: Compositions, methods, and systems for the development and use of heparosan as a therapeutic modifying agent or vehicle which can modulate drug cargo pharmacokinetics and behavior within a mammalian patient.
    Type: Application
    Filed: March 11, 2021
    Publication date: September 9, 2021
    Inventor: Paul L. DEANGELIS
  • CONJUGATES WITH INTERNAL AND TERMINAL-END HEPAROSAN LINKAGES
    Publication number: 20210244822
    Abstract: Described herein are compositions such as antibody-drug conjugates that include a heparosan polymer. In some embodiments, a targeting moiety is bound to an end of the heparosan polymer or to an internal monomeric subunit of the heparosan polymer. In some embodiments, a payload molecule is bound to an end of the heparosan or to an internal monomeric subunit. Some embodiments relate to methods of making and using the compositions.
    Type: Application
    Filed: June 21, 2019
    Publication date: August 12, 2021
    Inventor: Paul L. DeAngelis
  • SULFUR-CONTAINING GLYCANS AND POLYSACCHARIDES AND METHODS OF CHEMOENZYMATIC SYNTHESIS THEREOF
    Publication number: 20210230313
    Abstract: Described herein are sulfur-containing glycosaminoglycans, and methods of making and using them. For example, heparosan and hyaluronan analogs are described which incorporate one or more sulfur-containing sugar units that include one or more free sulfhydryls and/or one or more thio-glycosidic linkages. In some embodiments, the glycosaminoglycans are included in pharmaceutical or bioadhesive compositions.
    Type: Application
    Filed: May 24, 2019
    Publication date: July 29, 2021
    Inventors: Paul L. DeAngelis, Dixy E, Green, Robert J. Linhardt, Xing Zhang, Victor Schuitz
  • High molecular weight heparosan polymers and methods of production and use thereof
    Patent number: 10392642
    Abstract: High molecular weight heparosan polymers are described, as are methods of producing and using the high molecular weight heparosan polymers.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: August 27, 2019
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Paul L. DeAngelis, Phillip E. Pummill, Regina C. Visser
  • Methods of producing testosteronan polymers using testosteronan synthase
    Patent number: 10273517
    Abstract: Testosteronan, a heparosan analog having the structure [-4-D-GlcUA-?1,4-D-GlcNAc-?1-]n, is produced by testosteronan synthase, a single protein that is a dual-action catalyst that utilizes UDP-GlcUA and UDP-GlcNAc to synthesize a polysaccharide having the structure [-4-D-GlcUA-?1,4-D-GlcNAc-?1-]n.
    Type: Grant
    Filed: May 15, 2017
    Date of Patent: April 30, 2019
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Paul L. DeAngelis, Nigel J. Otto
  • HEPAROSAN-POLYPEPTIDE AND HEPAROSAN-POLYNUCLEOTIDE DRUG CONJUGATES AND METHODS OF MAKING AND USING SAME
    Publication number: 20180369270
    Abstract: Compositions containing conjugates of heparosan polymer with at least one drug are disclosed, along with methods of production and use thereof.
    Type: Application
    Filed: March 23, 2018
    Publication date: December 27, 2018
    Inventor: Paul L. DeAngelis
  • HIGH MOLECULAR WEIGHT HEPAROSAN POLYMERS AND METHODS OF PRODUCTION AND USE THEREOF
    Publication number: 20180251803
    Abstract: High molecular weight heparosan polymers are described, as are methods of producing and using the high molecular weight heparosan polymers.
    Type: Application
    Filed: February 5, 2018
    Publication date: September 6, 2018
    Inventors: Paul L. DeAngelis, Phillip E. Pummill, Regina C. Visser
  • Heparosan-polypeptide and heparosan-polynucleotide drug conjugates and methods of making and using same
    Patent number: 9925209
    Abstract: Compositions containing conjugates of heparosan polymer with at least one drug are disclosed, along with methods of production and use thereof.
    Type: Grant
    Filed: November 7, 2014
    Date of Patent: March 27, 2018
    Assignee: THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA
    Inventor: Paul L. DeAngelis
  • High molecular weight heparosan polymers and methods of production of use thereof
    Patent number: 9885072
    Abstract: High molecular weight heparosan polymers are described, as are methods of producing and using the high molecular weight heparosan polymers.
    Type: Grant
    Filed: March 23, 2017
    Date of Patent: February 6, 2018
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Paul L. DeAngelis, Phillip Pummill, Regina C. Visser
  • Heparosan Polymers and Methods of Making and Using Same for the Enhancement of Therapeutics
    Publication number: 20170252454
    Abstract: Compositions, methods, and systems are disclosed for the development and use of heparosan as a therapeutic modifying agent or vehicle which can modulate drug cargo pharmacokinetics and behavior within a mammalian patient.
    Type: Application
    Filed: May 17, 2017
    Publication date: September 7, 2017
    Inventor: Paul L. DeAngelis
  • Methods of Producing Testosteronan Polymers Using Testosteronan Synthase
    Publication number: 20170247732
    Abstract: Testosteronan, a heparosan analog having the structure [-4-D-GlcUA-?1,4-D-GlcNAc-?1-]n, is produced by testosteronan synthase, a single protein that is a dual-action catalyst that utilizes UDP-GlcUA and UDP-GlcNAc to synthesize a polysaccharide having the structure [-4-D-GlcUA-?1,4-D-GlcNAc-?1-]n.
    Type: Application
    Filed: May 15, 2017
    Publication date: August 31, 2017
    Inventors: Paul L. DeAngelis, Nigel J. Otto
  • HIGH MOLECULAR WEIGHT HEPAROSAN POLYMERS AND METHODS OF PRODUCTION OF USE THEREOF
    Publication number: 20170198325
    Abstract: High molecular weight heparosan polymers are described, as are methods of producing and using the high molecular weight heparosan polymers.
    Type: Application
    Filed: March 23, 2017
    Publication date: July 13, 2017
    Inventors: Paul L. DeAngelis, Phillip Pummill, Regina C. Visser
  • Heparosan-Based Biomaterials and Coatings and Methods of Production and Use Thereof
    Publication number: 20170190803
    Abstract: Biomaterial compositions that include an isolated heparosan polymer are disclosed, as well as kits containing such biomaterial compositions and methods of producing and using such biomaterial compositions.
    Type: Application
    Filed: March 13, 2017
    Publication date: July 6, 2017
    Inventor: Paul L. DeAngelis
  • Methods of producing testosteronan polymers using testosteronan synthase
    Patent number: 9695427
    Abstract: Testosteronan, a heparosan analog having the structure [-4-D-GlcUA-?1,4-D-GlcNAc-?1-]n, is produced by testosteronan synthase, a single protein that is a dual-action catalyst that utilizes UDP-GlcUA and UDP-GlcNAc to synthesize a polysaccharide having the structure [-4-D-GlcUA-?1,4-D-GlcNAc-?1-]n.
    Type: Grant
    Filed: January 31, 2012
    Date of Patent: July 4, 2017
    Assignee: The Board of Regents of the University of Oklahoma
    Inventors: Paul L. DeAngelis, Nigel J. Otto
  • Heparosan polymers and methods of making and using same for the enhancement of therapeutics
    Patent number: 9687559
    Abstract: The present invention includes compositions, methods, and systems for the development and use of heparosan, a natural polymer related to heparin, as a new therapeutic modifying agent or vehicle which can modulate drug cargo pharmacokinetics and behavior within a mammalian patient.
    Type: Grant
    Filed: September 9, 2009
    Date of Patent: June 27, 2017
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Paul L. DeAngelis
  • Heparosan-based biomaterials and coatings and methods of production and use thereof
    Patent number: 9629914
    Abstract: Biomaterial compositions that include an isolated heparosan polymer are disclosed, as well as kits containing such biomaterial compositions and methods of producing and using such biomaterial compositions.
    Type: Grant
    Filed: October 22, 2013
    Date of Patent: April 25, 2017
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Paul L. DeAngelis
  • Heparosan polymers and methods of making and using same for the enhancement of therapeutics
    Patent number: 9603945
    Abstract: Compositions, methods, and systems are disclosed for the development and use of heparosan, a natural polymer related to heparin, as a new therapeutic modifying agent or vehicle which can modulate drug cargo pharmacokinetics and behavior within a mammalian patient.
    Type: Grant
    Filed: December 14, 2012
    Date of Patent: March 28, 2017
    Assignee: The Board of Regents of the University of Oklahoma
    Inventor: Paul L. DeAngelis
  • Coagulation factor VII polypeptides
    Patent number: 9370583
    Abstract: The present invention relates to modified coagulation Factor VII polypeptides exhibiting increased resistance to antithrombin inactivation and enhanced proteolytic activity. The present invention also relates to polynucleotide constructs encoding such polypeptides, vectors and host cells comprising and expressing such polynucleotides, pharmaceutical compositions, uses and methods of treatment.
    Type: Grant
    Filed: November 9, 2015
    Date of Patent: June 21, 2016
    Assignee: NOVO NORDISK HEALTHCARE AG
    Inventors: Henrik Oestergaard, Prafull S. Gandhi, Ole Hvilsted Olsen, Carsten Behrens, Paul L. DeAngelis, Friedrich Michael Haller
  • Factor VIII Conjugates
    Publication number: 20160120953
    Abstract: The present invention relates to FVIII conjugated to heparosan (HEP) polymers, methods for the manufacture thereof and uses of such conjugates. The resultant conjugates may be used in the treatment or prevention of bleeding disorders such as haemophilia.
    Type: Application
    Filed: November 4, 2015
    Publication date: May 5, 2016
    Inventors: Carsten Behrens, Paul L. DeAngelis, Friedrich Michael Haller
  • COAGULATION FACTOR VII POLYPEPTIDES
    Publication number: 20160120992
    Abstract: The present invention relates to modified coagulation Factor VII polypeptides exhibiting increased resistance to antithrombin inactivation and enhanced proteolytic activity. The present invention also relates to polynucleotide constructs encoding such polypeptides, vectors and host cells comprising and expressing such polynucleotides, pharmaceutical compositions, uses and methods of treatment.
    Type: Application
    Filed: November 9, 2015
    Publication date: May 5, 2016
    Inventors: Henrik Oestergaard, Prafull S. Gandhi, Ole Hvilsted Olsen, Carsten Behrens, Paul L. DeAngelis, Friedrich Michael Haller