Abstract: This disclosure relates to JAK1 pathway inhibitors and their use in treating vitiligo.

Abstract: Fibrous structures comprising spunbond filaments and solid additives and methods for making such fibrous structures are provided.

Abstract: A coated glass pharmaceutical package includes a glass body having a Type 1 chemical durability according to USP 660, at least a class A2 base resistance or better according to ISO 695, and at least a type HGB2 hydrolytic resistance or better according to ISO 719, the glass body having an interior surface and an exterior surface and a wall extending therebetween. A lubricous coating having a thickness of less than or equal to 90 nm may be positioned on at least a portion of the exterior surface of the glass body but not on any portion of the interior surface. The portion of the coated glass package with the lubricous coating comprises a coefficient of friction that is at least 20% less than an uncoated glass package and the coefficient of friction does not increase by more than 30% after undergoing a depyrogenation cycle including exposure to a temperature of 250° C. for a time period of 30 minutes.

Abstract: A sensing device for a hydrant can include a sensor located entirely within an interior cavity of a hydrant body of the hydrant and configured to measure a property of a fluid of a fluid distribution system and an antenna in communication with the sensor and positioned within the interior cavity.

Abstract: Mobile management method, system and client. Method includes receiving a DNS query for a host name from an application on client; retrieving reputation data associated with host name from a local cache on client; and determining a policy based on host name and the reputation data. Based on determined policy for the host name, blocking attempted network flows to a host corresponding to host name to produce blocked attempted network flows. Method also includes sending attempted network flow metadata related to the blocked attempted network flows to a collector on client; transmitting the attempted network flow metadata from the collector to a VPN server pool via a VPN tunnel; and producing an anomaly report from the transmitted attempted network flow metadata. The anomaly report includes at least one of anomalies, cohorts, trends, location boundaries, detected network security issues, detected compromised clients and/or optimized network usage.

Abstract: A humidification system can include a heater base, a humidification chamber, and a breathing circuit. A cartridge can be removably coupled to the heater base. The cartridge can include various sensors, probes, sensor wire connectors, heater wire connectors, and/or other features. The cartridge can include features configured to mate with corresponding features on the humidification chamber and the heater base. The cartridge includes a memory, such as an EEPROM, or other suitable storage device. When the cartridge is installed on the heater base, the memory is electrically connected to a processor and/or memory of the heater base. Various models of cartridges can be produced for use with different humidification chambers, breathing circuits, and/or therapies. A connector can be configured to couple an inspiratory conduit to an outlet port of the humidification chamber. The connector can provide a pneumatic connection to the outlet port and an electrical connection to the cartridge.

Abstract: Fiber optic terminals, tools and methods for adjusting a split ratio of a fiber optic terminal are disclosed. In one embodiment, a tool for adjusting a split ratio of a fiber optic terminal includes an axle for insertion into a port of the fiber optic terminal, and a terminal engagement body disposed about the axle. The terminal engagement body includes a terminal engagement feature for engaging an alignment feature within the fiber optic terminal, wherein the axle is free to rotate with respect to the terminal engagement body, and a set-point indicator. The tool further includes an end piece coupled to the axle, and a plurality of set-point markers, wherein rotation of the end piece causes rotation of the axle and an alignment between one set-point marker of the plurality of set-point markers with the set-point indicator indicates the split ratio of the fiber optic terminal.

Abstract: A method of generating a blood pressure estimation for a subject includes receiving real-time PPG data from a PPG sensor attached to the subject, and generating a blood pressure estimation for the subject via an adaptive predictive model using the real time PPG data. The method includes receiving a real-time measurement of blood pressure via a blood pressure monitoring device attached to the subject and, in response to receiving the real-time measurement of blood pressure, updating one or more parameters of the model in real-time to improve blood pressure estimation accuracy of the model. The method may also include detecting whether the generated blood pressure estimation is above or below a threshold and, in response to determining that the generated biometric estimation is above or below the threshold, receiving a real-time measurement of blood pressure and then updating the parameters of the model to improve blood pressure estimation accuracy of the model.

Abstract: A system for cooling a hermetic motor includes a motor cooling refrigerant flow path configured to direct refrigerant from a condenser disposed along a refrigerant loop to a hermetic motor, and from the hermetic motor back to the refrigerant loop, and a housing of the hermetic motor disposed along the motor cooling refrigerant flow path and configured to receive the refrigerant from the condenser, wherein the housing of the hermetic motor comprises an annulus surrounding at least a portion of a stator of the hermetic motor, and wherein the annulus comprises a plurality of openings configured to direct refrigerant toward the stator and into a cavity of the housing of the hermetic motor.

Abstract: A chemical mechanical polishing pad includes a surface portion of a first material. The surface portion includes a plurality of grooves. A first portion of the grooves are exposed grooves located at a surface of the chemical mechanical polishing pad. A second portion of the grooves are buried grooves embedded below the surface of the chemical mechanical polishing pad, such that, during use of the chemical mechanical polishing pad, one or more of the buried grooves are exposed at the surface.

Abstract: A gear forming tool includes an outer sleeve having an outer sleeve aperture and an inner sleeve having an inner sleeve aperture in fluid communication with the outer sleeve aperture, a tool holder disposed within the outer sleeve, and a 3D printed gear cutting tool with a plurality of tool cutting edges and a plurality of capillaries attached to the tool holder. The tool holder has a plurality of fluid channels configured to be in fluid communication with the inner sleeve aperture and the plurality of capillaries of the 3D printed gear cutting tool such that cutting fluid flows through the outer sleeve, the inner sleeve, the plurality of fluid channels of the tool holder, and the plurality of capillaries to the plurality of tool cutting edges.

Abstract: A power tool having multiple wireless communication states and a method of wirelessly communicating by a power tool. The power tool includes a motor, a battery pack interface that selectively receives a battery pack, a backup power source, and a wireless communication controller coupled to the backup power source and the battery pack interface. The wireless communication controller operates in a connectable state when coupled to a battery pack and transmits tool operational data to the external device and receives tool configuration data from the external device. The wireless communication controller operates in an advertisement state when the wireless communication controller is coupled to and powered by the backup power source. In the advertisement state, the wireless communication controller is configured to transmit the unique tool identifier. The external device may also display an indication of the communication state of the power tool.

Abstract: The present disclosure provides creatine prodrug analogs and their compositions useful for the treatment of creatine deficiencies.

Abstract: Systems and techniques for authentication of impaired voices are described herein. A voice profile may be generated for a user. An audio stream may be received including an authentication voice of the user. It may be determined that the authentication voice does not match a first set of authentication criteria. The audio stream may be compared to a second set of authentication criteria. The user may be authenticated based on the comparison.

Abstract: A patient interface for delivery of a supply of pressurised air or breathable gas to an entrance of a patient's airways comprising: a cushion member that includes a retaining structure and a seal-forming structure permanently connected to the retaining structure; a frame member attachable to the retaining structure; and a positioning and stabilising structure attachable to the frame member.

Abstract: A sole structure for an article of footwear includes a chassis and a cushioning arrangement. The chassis includes a recess formed between a first surface and a second surface facing the first surface. The cushioning arrangement includes a first cushioning element protruding from the first surface and including a first plurality of lobes and a second cushioning element protruding from the second surface and including a second plurality of lobes contacting the first plurality of lobes. At least one of the first cushioning element and the second cushioning element may include a fluid-filled bladder. A first side of each cushioning element includes a substantially planar base and a second side of each cushioning element includes the lobes formed on an opposite side from the base. The base of each cushioning element is attached to a respective one of the surfaces of the recess.

Abstract: Microelectromechanical systems (MEMS) switches are disclosed. Parallel configurations of back-to-back MEMS switches are disclosed in some embodiments. An isolation connection of constant electrical potential may be made to a midpoint of the back-to-back switches. In some embodiments, a separate MEMS switch is provided as a shunt switch for the main MEMS switch. MEMS switch device configurations having multiple switchable signal paths each coupling a common input electrode to a respective output electrode are also disclosed. The MEMS switch device includes shunt switches each coupling a respective output electrode to a reference potential. The presence of a shunt switch coupled to an output electrode enhances the isolation of the signal path corresponding to that output electrode when the path is open.

Abstract: Disclosed is a kingpin assembly comprising a receiver housing, a collet sleeve in the receiver housing, a kingpin in the collet, a spring on the kingpin, a retainer cap on the spring, and a plurality of connectors connecting the receiver housing to the retainer cap. In one embodiment, the retainer cap exerts a pressure against the spring which in turn exerts pressure to a top of the king pin pressing the king pin and collet towards a bottom of the receiver housing.

Abstract: A mass spectrometer comprising: a vacuum housing comprising a first vacuum chamber having a first gas exhaust port; a gas pump (1700) having a first gas inlet port connected to the first gas exhaust port (H1) by a first gas conduit for evacuating the first vacuum chamber, and a first apertured cover (2010) arranged over the first gas exhaust port (H1) or first gas inlet port, or in the first gas conduit therebetween.

Abstract: Fibrous structures containing filaments and solid additives, and more particularly to fibrous structures containing filaments and solid additives wherein the fibrous structure has three or more regions that exhibit different characteristics and/or properties and methods for making same, are provided.