Patents by Inventor Paul Lewer

Paul Lewer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Identification and characterization of the spinactin biosysnthesis gene cluster from spinosyn producing
    Patent number: 9631195
    Abstract: This disclosure concerns methods for producing a spinosyn producing host cell that comprises modifying a nucleic acid molecule encoding for spinactin by introducing, mutating, deleting, replacing or inactivating a nucleic acid sequence encoding one or more activities of a polypeptide encoded by the nucleic acid molecule. Methods for producing a modified Saccharopolyspora spinosa organism or strain are also disclosed.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: April 25, 2017
    Assignee: Dow AgroSciences LLC
    Inventors: Nadaraj Palaniappan, Paul Lewer, Paul Richard Graupner
  • CHIMERIC NON-RIBOSOMAL PEPTIDE SYNTHETASE
    Publication number: 20160201099
    Abstract: The present disclosure provides novel compositions and methods for the production and use of polynucleotide sequences encoding a chimeric non-ribosomal peptide synthetase (NRPS) fusion protein for the biosynthesis of N-acylglycine biosurfactants within a heterologous expression system.
    Type: Application
    Filed: September 25, 2015
    Publication date: July 14, 2016
    Inventors: Amudhan VENKATESWARAN, Babu RAMAN, Paul SWANSON, Paul LEWER
  • HETEROLOGOUS EXPRESSION OF GLYCINE N-ACYLTRANSFERASE PROTEINS
    Publication number: 20160090577
    Abstract: The present disclosure provides novel compositions and methods for the production and use of polynucleotide sequences encoding a glycine N-acyltransferase protein (GLYAT, GLYATL 1, GLYATL 2, and GLYATL 3) for the biosynthesis of N-acylglycine biosurfactants within a heterologous expression system.
    Type: Application
    Filed: September 25, 2015
    Publication date: March 31, 2016
    Inventors: Amudhan VENKATESWARAN, Babu RAMAN, Paul SWANSON, Paul LEWER
  • Spinosyn-producing polyketide synthases
    Patent number: 9137992
    Abstract: The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning in Saccharopolyspora spinosa to produce the spinosyns, and methods of controlling insects using the spinosyns.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: September 22, 2015
    Assignee: Dow AgroScienceas LLC
    Inventors: Lesley S. Burns, Paul Richard Graupner, Paul Lewer, Christine J. Martin, William A. Vousden, Clive Waldron, Barnie Wilkinson
  • SPINOSYN-PRODUCING POLYKETIDE SYNTHASES
    Publication number: 20140080777
    Abstract: The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning in Saccharopolyspora spinosa to produce the spinosyns, and methods of controlling insects using the spinosyns.
    Type: Application
    Filed: November 18, 2013
    Publication date: March 20, 2014
    Applicant: DOW AGROSCIENCES LLC
    Inventors: Lesley S. Burns, Paul Richard Graupner, Paul Lewer, Christine J. Martin, William A. Vousden, Clive Waldron, Barnie Wilkinson
  • Spinosyn-producing polyketide synthases
    Patent number: 8624009
    Abstract: The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning in Saccharopolyspora spinosa to produce the spinosyns, and methods of controlling insects using the spinosyns.
    Type: Grant
    Filed: March 28, 2011
    Date of Patent: January 7, 2014
    Assignee: Dow AgroSciences, LLC.
    Inventors: Lesley S. Burns, Paul R. Graupner, Paul Lewer, Christine J. Martin, William A. Vousden, Clive Waldron, Barrie Wilkinson
  • NOVEL SPINOSYN-PRODUCING POLYKETIDE SYNTHASES
    Publication number: 20110178036
    Abstract: The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning in Saccharopolyspora spinosa to produce the spinosyns, and methods of controlling insects using the spinosyns.
    Type: Application
    Filed: March 28, 2011
    Publication date: July 21, 2011
    Inventors: Lesley S. Burns, Paul R. Graupner, Paul Lewer, Christine J. Martin, William A. Vousden, Clive Waldron, Barrie Wilkinson
  • SPINOSYN-PRODUCING POLYKETIDE SYNTHASES
    Publication number: 20100068785
    Abstract: The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning in Saccharopolyspora spinosa to produce the spinosyns, and methods of controlling insects using the spinosyns.
    Type: Application
    Filed: November 11, 2009
    Publication date: March 18, 2010
    Inventors: Lesley S. Burns, Paul R. Graupner, Paul Lewer, Christine J. Martin, William A. Vousden, Clive Waldron, Barrie Wilkinson
  • Spinosyn-producing polyketide synthases
    Patent number: 7626010
    Abstract: The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning in Saccharopolyspora spinosa to produce the spinosyns, and methods of controlling insects using the spinosyns.
    Type: Grant
    Filed: October 20, 2005
    Date of Patent: December 1, 2009
    Assignee: Dow AgroSciences LLC
    Inventors: Lesley S. Burns, Paul R. Graupner, Paul Lewer, Christine J. Martin, William A. Vousden, Clive Waldron, Barrie Wilkinson
  • Novel spinosyn-producing polyketide synthases
    Publication number: 20060040877
    Abstract: The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning in Saccharopolyspora spinosa to produce the spinosyns, and methods of controlling insects using the spinosyns.
    Type: Application
    Filed: October 20, 2005
    Publication date: February 23, 2006
    Inventors: Lesley Burns, Paul Graupner, Paul Lewer, Christine Martin, William Vousden, Clive Waldron, Barrie Wilkinson
  • Insecticidal activity of a cyclic peptide
    Publication number: 20050261174
    Abstract: A cyclic peptide isolated from an extract of the bark of a Madagascan plant, having a structure of formula (I), has insecticidal activity.
    Type: Application
    Filed: May 20, 2005
    Publication date: November 24, 2005
    Inventors: Paul Lewer, Dennis Duebelbeis, Paul Graupner, Jim Huang
  • Synthetic derivatives of 21-butenyl and related spinosyns
    Patent number: 6919464
    Abstract: Macrolide compounds produced by synthetic modification of factors produced by NRRL 30141 have insecticidal and acaricidal activity and are useful intermediates for preparing additional insecticidal and acaricidal compounds
    Type: Grant
    Filed: March 21, 2002
    Date of Patent: July 19, 2005
    Assignee: Dow AgroSciences LLC
    Inventors: Gary D. Crouse, Donald R. Hahn, Paul R. Graupner, Jeffrey R. Gilbert, Paul Lewer, Jesse L. Balcer
  • Pesticidal macrolides
    Publication number: 20050043252
    Abstract: Macrolide compounds produced by culturing Saccharopolyspora species LW107129 (NRRL 30141) have insecticidal and acaricidal activity and are useful intermediates for preparing spinosyn analogs.
    Type: Application
    Filed: August 17, 2004
    Publication date: February 24, 2005
    Inventors: Paul Lewer, Donald Hann, Laura Karr, Paul Graupper, Jeffrey Gilbert, Thomas Worden, Raymond Yao, Dennis Norton
  • Pesticidal macrolides
    Patent number: 6800614
    Abstract: Macrolide compounds produced by culturing Saccharopolyspora species LW107129 (NRRL 30141) have insecticidal and acaricidal activity and are useful intermediates for preparing spinosyn analogs.
    Type: Grant
    Filed: August 13, 2002
    Date of Patent: October 5, 2004
    Assignee: Dow AgroSciences LLC
    Inventors: Paul Lewer, Donald R. Hahn, Laura L. Karr, Paul R. Graupner, Jeffrey R. Gilbert, Thomas V. Worden, Raymond C. Yao, Dennis W. Norton
  • Pesticidal spinosyn derivates
    Publication number: 20040097377
    Abstract: Macrolide compounds produced by culturing novel mutant Saccharopolyspora sp. strains have insecticidal and acaricidal activity and are useful intermediates for preparing spinosyn analogs.
    Type: Application
    Filed: September 15, 2003
    Publication date: May 20, 2004
    Inventors: Donald R. Hahn, Jesse L. Balcer, Paul Lewer, Jeffrey R. Gilbert, Paul R. Grausner
  • Novel spinosyn-producing polyketide synthases
    Publication number: 20030225006
    Abstract: The invention provides, biologically active spinosyns, hybrid spinosyn polyketide synthases capable of functioning in Saccharopolyspora spinosa to produce the spinosyns, and methods of controlling insects using the spinosyns.
    Type: Application
    Filed: February 19, 2003
    Publication date: December 4, 2003
    Inventors: Lesley S. Burns, Paul R. Graupner, Paul Lewer, Christine J. Martin, William A. Vousden, Clive Waldron, Barrie Wilkinson
  • Pesticidal macrolides
    Publication number: 20030186899
    Abstract: Macrolide compounds produced by culturing Saccharopolyspora species LW107129 (NRRL 30141) have insecticidal and acaricidal activity and are useful intermediates for preparing spinosyn analogs.
    Type: Application
    Filed: August 13, 2002
    Publication date: October 2, 2003
    Inventors: Paul Lewer, Donald R. Hahn, Laura L. Karr, Paul R. Graupner, Jeffrey R. Gilbert, Thomas V. Worden, Raymond C. Yao, Dennis W. Norton
  • Pesticidal macrolides
    Patent number: 6455504
    Abstract: Macrolide compounds produced by culturing Saccharopolyspora species LW107129 (NRRL 30141) have insecticidal and acaricidal activity and are useful intermediates for preparing spinosyn analogs.
    Type: Grant
    Filed: September 13, 2000
    Date of Patent: September 24, 2002
    Assignee: Dow AgroSciences LLC
    Inventors: Paul Lewer, Donald R. Hahn, Laura L. Karr, Paul R. Graupner, Jeffrey R. Gilbert, Thomas V. Worden, Raymond C. Yao, Dennis W. Norton