Patents by Inventor Paul Luciw
Paul Luciw has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7527925Abstract: Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare antibodies, where both the polypeptides and antibodies may be employed as diagnostic reagents or in therapy, e.g., vaccines and passive immunization. The sequences provide detection of the viral infectious agents associated with the indicated syndromes and can be used for expression of antigenic polypeptides.Type: GrantFiled: May 17, 1995Date of Patent: May 5, 2009Assignee: Novartis Vaccines and Diagnostics, Inc.Inventors: Paul A. Luciw, Dino Dina, Kathelyn Steimer, Ray Sanchez Pescador, Carlos George-Nascimento, Deborah Parkes, Rob Hallewell, Philip J. Barr, Martha Truett
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Patent number: 7442525Abstract: Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare antibodies, where both the polypeptides and antibodies may be employed as diagnostic reagents or in therapy, e.g., vaccines and passive immunization. The sequences provide detection of the viral infectious agents associated with the indicated syndromes and can be used for expression of antigenic polypeptides.Type: GrantFiled: May 17, 1995Date of Patent: October 28, 2008Assignee: Novartis Vaccines and Diagnostics, Inc.Inventors: Paul A. Luciw, Dino Dina, Kathelyn Steimer, Ray Sanchez Pescador, Carlos George-Nascimento, Deborah Parkes, Rob Hallewell, Philip J. Barr, Martha Truett
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Patent number: 7425428Abstract: Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare antibodies, where both the polypeptides and antibodies may be employed as diagnostic reagents or in therapy, e.g., vaccines and passive immunization. The sequences provide detection of the viral infectious agents associated with the indicated syndromes and can be used for expression of antigenic polypeptides.Type: GrantFiled: May 17, 1995Date of Patent: September 16, 2008Assignee: Novartis Vaccines and Diagnostics, Inc.Inventors: Paul A. Luciw, Dino Dina, Kathelyn Steimer, Ray Sanchez Pescador, Carlos George-Nascimento, Deborah Parkes, Rob Hallewell, Philip J. Barr, Martha Truett
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Patent number: 7408053Abstract: Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare antibodies, where both the polypeptides and antibodies may be employed as diagnostic reagents or in therapy, e.g., vaccines and passive immunization. The sequences provide detection of the viral infectious agents associated with the indicated syndromes and can be used for expression of antigenic polypeptides.Type: GrantFiled: May 17, 1995Date of Patent: August 5, 2008Assignee: Novartis Vaccines and Diagnostics, Inc.Inventors: Paul A. Luciw, Dino Dina
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Patent number: 7393949Abstract: Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare antibodies, where both the polypeptides and antibodies may be employed as diagnostic reagents or in therapy, e.g., vaccines and passive immunization. The sequences provide detection of the viral infectious agents associated with the indicated syndromes and can be used for expression of antigenic polypeptides.Type: GrantFiled: May 17, 1995Date of Patent: July 1, 2008Assignee: Novartis Vaccines and Diagnostics, Inc.Inventors: Paul A. Luciw, Dino Dina, Kathelyn Steimer, Ray Sanchez Pescador, Carlos George-Nascimento, Deborah Parkes, Rob Hallewell, Philip J. Barr, Martha Truett
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Patent number: 7285271Abstract: Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare antibodies, where both the polypeptides and antibodies may be employed as diagnostic reagents or in therapy, e.g., vaccines and passive immunization. The sequences provide detection of the viral infectious agents associated with the indicated syndromes and can be used for expression of antigenic polypeptides.Type: GrantFiled: May 31, 1995Date of Patent: October 23, 2007Assignee: Novartis Vaccines and Diagnostics, Inc.Inventors: Paul A. Luciw, Dino Dina
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Patent number: 7273695Abstract: Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare antibodies, where both the polypeptides and antibodies may be employed as diagnostic reagents or in therapy, e.g., vaccines and passive immunization. The sequences provide detection of the viral infectious agents associated with the indicated syndromes and can be used for expression of antigenic polypeptides.Type: GrantFiled: July 8, 1993Date of Patent: September 25, 2007Assignee: Novartis Vaccines and Diagnostics, Inc.Inventors: Paul A. Luciw, Dino Dina
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Patent number: 7205101Abstract: Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare antibodies, where both the polypeptides and antibodies may be employed as diagnostic reagents or in therapy, e.g., vaccines and passive immunization. The sequences provide detection of the viral infectious agents associated with the indicated syndromes and can be used for expression of antigenic polypeptides.Type: GrantFiled: May 17, 1995Date of Patent: April 17, 2007Assignee: Novartis Vaccines and Diagnostics, Inc.Inventors: Paul A. Luciw, Dino Dina
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Publication number: 20050256056Abstract: Provided are peptides, peptide analogs, and peptide mimetics that inhibit HIV activity, pharmaceutical compositions comprising such peptides and peptide analogs, and methods of inhibiting HIV activity and/or transmission by administering the peptides and peptide analogs to a subject.Type: ApplicationFiled: December 2, 2004Publication date: November 17, 2005Applicant: The Regents of the University of California Office of Technology Transfer University of CaliforniaInventors: Thomas North, Kit Lam, Paul Luciw, Yen Duong
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Publication number: 20040229284Abstract: Several related methods for multiplexed detection of one or more posttranslational modifications of a plurality of proteins are provided. Methods for detecting one or more nucleic acid binding proteins are also provided. Use of such methods (e.g., methods of detecting phosphorylation of protein kinases) for diagnosis, prognosis and monitoring of disease is also included. Compositions, systems and kits that relate to each of the methods are described.Type: ApplicationFiled: February 18, 2004Publication date: November 18, 2004Applicant: The Regents of the University of CaliforniaInventors: Paul A. Luciw, Imran H. Khan, Hsing-Jien Kung
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Patent number: 6531276Abstract: Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare antibodies, where both the polypeptides and antibodies may be employed as diagnostic reagents or in therapy, e.g., vaccines and passive immunization. The sequences provide detection of the viral infectious agents associated with the indicated syndromes and can be used for expression of antigenic polypeptides.Type: GrantFiled: March 14, 1995Date of Patent: March 11, 2003Assignee: Chiron CorporationInventors: Paul A. Luciw, Dino Dina
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Patent number: 6458527Abstract: Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare antibodies, where both the polypeptides and antibodies may be employed as diagnostic reagents or in therapy, e.g., vaccines and passive immunization. The sequences provide detection of the viral infectious agents associated with the indicated syndromes and can be used for expression of antigenic polypeptides.Type: GrantFiled: June 28, 1993Date of Patent: October 1, 2002Assignee: Chiron CorporationInventors: Paul A. Luciw, Dino Dina, Kathelyn Steimer, Ray Sanchez Pescador, Carlos George-Nascimento, Deborah Parkes, Rob Hallewell, Philip J. Barr, Martha Truett
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Patent number: 6326007Abstract: This invention discloses recombinant vectors and live attenuated pathogens produced by these vectors which are useful as vaccines and therapeutic agents. Particularly disclosed are live attenuated recombinant viruses that remain at very low virus loads, and preferably do not persist in the infected hosts. These recombinant viruses are useful against retroviruses such as human immunodeficiency virus and against acquired immunodeficiency diseases. In the recombinant vectors and pathogens, one or more genes, or part of the gene(s), responsible for pathogenesis have been completely or partially rendered nonfunctional, e.g., by full or partial deletion or mutagenesis. Further, the recombinant vectors and pathogens contain one or more genes encoding cytokine(s) and/or lymphokine(s).Type: GrantFiled: July 20, 1995Date of Patent: December 4, 2001Assignee: The Regents of the University of CaliforniaInventors: Tilahun D. Yilma, Luis D. Giavedoni, Paul A. Luciw
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Patent number: 6013432Abstract: Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare antibodies, where both the polypeptides and antibodies may be employed as diagnostic reagents or in therapy, e.g., vaccines and passive immunization. The sequences provide detection of the viral infectious agents associated with the indicated syndromes and can be used for expression of antigenic polypeptides.Type: GrantFiled: May 17, 1995Date of Patent: January 11, 2000Assignee: Chiron CorporationInventors: Paul A. Luciw, Dino Dina
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Patent number: 6004799Abstract: This invention discloses live-attenuated feline immunodeficiency virus (FIV), and recombinant vectors for producing them, useful as vaccines and therapeutic agents against FIV and diseases associated with virulent FIV infection. In the recombinant vectors and FIVs, one or more genes, or part of the gene(s), responsible for FIV pathogenesis have been completely or partially rendered nonfunctional, e.g., by full or partial deletion or mutagenesis. These anti-FIV vaccines may be given to susceptible hosts in the form of infectious virus or cloned DNA.Type: GrantFiled: March 5, 1997Date of Patent: December 21, 1999Assignee: The Regents of the University of CaliforniaInventors: Paul A. Luciw, Ellen E. Sparger
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Patent number: 5688688Abstract: Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare antibodies, where both the polypeptides and antibodies may be employed as diagnostic reagents or in therapy, e.g., vaccines and passive immunization. The sequences provide detection of the viral infectious agents associated with the indicated syndromes and can be used for expression of antigenic polypeptides.Type: GrantFiled: August 10, 1994Date of Patent: November 18, 1997Assignee: Chiron CorporationInventors: Paul A. Luciw, Dino Dina, Steven Rosenberg, Barbara S. Chapman, Richard M. Thayer, Nancy L. Haigwood
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Patent number: 5156949Abstract: Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare antibodies, where both the polypeptides and antibodies may be employed as diagnostic reagents or in therapy, e.g., vaccines and passive immunization. The sequences provide detection of the viral infectious agents associated with the indicated syndromes and can be used for expression of antigenic polypeptides.Type: GrantFiled: December 24, 1987Date of Patent: October 20, 1992Assignee: Chiron CorporationInventors: Paul A. Luciw, Dino Dina
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Patent number: 5152982Abstract: Novel methods and compositions are provided for vaccinating a host susceptible to viral infection. Particularly, an initial injection is employed of one or more polypeptides associated with the host immune response to the pathogen followed by administration of the pathogen in attenuated form, particularly having a deletion associated with the gene expressing at least one of said polypeptides. In this manner, hosts may be vaccinated so as to maintain a strong defensive posture against infection from the pathogen. The method is specifically illustrated with feline leukemia virus.Type: GrantFiled: December 10, 1991Date of Patent: October 6, 1992Assignee: Chiron CorporationInventors: Deborah Parkes, Paul Luciw, Gary Van Nest, Dino Dina
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Patent number: 4876089Abstract: Methods and compositions are provided for the efficient production of a polypeptide having immunological reactivity corresponding to that of naturally-occurring envelope glycoproteins of feline leukemia virus. A DNA construct including a replication system recognized by yeast, and a viral envelope protein gene under the transcriptional control of a yeast promoter, and terminator is provided. By transforming a yeast host with the DNA construct, enhanced yields of the product may be obtained.Saccharomyces carlsbergensis strains 2150-2-3 (pCP-envB-R) and 2150-2-3 (pCP-envA-R) were deposited at the American Type Culture Collection on July 18, 1984, and granted accession nos. 20720 and 20721, respectively.Type: GrantFiled: August 14, 1987Date of Patent: October 24, 1989Assignee: Chiron CorporationInventors: Paul Luciw, Deborah L. Parkes, Gary A. Van Nest
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Patent number: RE41158Abstract: Polynucleotide sequences are provided for the diagnosis of the presence of retroviral infection in a human host associated with lymphadenopathy syndrome and/or acquired immune deficiency syndrome, for expression of polypeptides and use of the polypeptides to prepare antibodies, where both the polypeptides and antibodies may be employed as diagnostic reagents or in therapy, e.g., vaccines and passive immunization. The sequences provide detection of the viral infectious agents associated with the indicated syndromes and can be used for expression of antigenic polypeptides.Type: GrantFiled: January 12, 2009Date of Patent: March 2, 2010Assignee: Novartis Vaccines and Diagnostics, Inc.Inventors: Paul Luciw, Dino Dina