Abstract: PQQ and PQQ-generating compounds inhibit osteoclast cell formation and bone resorption, and those compounds can be used to treat medical conditions characterized by undesired bone resorption. PQQ-phosphonates that target osteoclasts at the bone-mineral interface are particularly useful in this regard.

Abstract: Methods are disclosed for treating PQQ-responsive heavy metal toxicity which include the administration of PQQ to a patient in need thereof. The toxicity may be associated with such heavy metals as lead, indium and vanadium.

Abstract: A method of resisting neurological damage caused by overstimulation of the NMDA receptor of nerve cells by glutamate includes exposing the NMDA receptors to an oxidizing agent to thereby diminish overall activity of the receptors following activation by glutamate. The oxidizing agent preferably is a material selected from the group consisting of pyrroloquinoline quinone and topa hydantoin.

Abstract: A method for resisting neurological damage caused by overstimulation of the MDA receptor of nerve cells by glutamate includes exposing the NMDA receptors to an oxidizing agent to thereby diminish overall activity of the receptors following activation by glutamate. The oxidizing agent preferably is a material selected from the group consisting of pyrroloquinoline quinone and topa hydantoin.

Abstract: A method of forming analyzable adducts in a mixture of compounds by contacting the mixture with a boron reagent having the formula of either ##STR1## where each X and Y is, independently, an alkyl group of 12 or fewer carbons or an aryl group of 6-20 carbons; or BZ.sub.3, where each Z is, independently, an alkyl group of 12 or fewer carbons, or an aryl group of 6-20 carbons.

Abstract: Compounds and methods featuring, in one aspect, compositions containing an organic boronic acid and one or more reporter groups.

Abstract: Conjugate composed of an oligonucleotide covalently bonded to a carrier.

Abstract: Copolymers having improved machining and water resistant properties are produced using a monomer containing an adduct protecting group, particularly an alkyl boronic acid adduct, of glyceryl acrylate or glyceryl methacrylate, in combination with an alkyl acrylate or methacrylate, and optionally a glycidyl acrylate or methacrylate. After machining and shaping, the adduct is removed to provide a hydrogel useful as a contact lens material.

Abstract: The invention provides new hydrogel forming materials comprising synthetic, hydrophilic, aqueous-insoluble polymer networks formed by copolymerization of a hydrophilic dihydroxyalkyl acrylate or methacrylate, a substantially water insoluble alkyl acrylate or methacrylate, one or more additional hydrophilic comonomers selected from the group of vinylic monomers, acrylates, and methacrylates, and a cross-linking agent. The hydrogels are preferably used for the formation of contact lenses, but may also be used for drug and pesticides delivery devices; dialysis, ultrafiltration and reverse osmosis membranes; implants in surgery and dentistry; and the like.

Abstract: Compounds and methods featuring, in one aspect, compositions containing an organic boronic acid and one or more reporter groups.

Abstract: Copolymers having improved machining and water resistant properties are produced using a monomer containing an adduct protecting group, particularly an alkyl boronic acid adduct, of glyceryl acrylate or glyceryl methacrylate, in combination with an alkyl acrylate or methacrylate, and optionally a glycidyl acrylate or methacrylate. After machining and shaping, the adduct is removed to provide a hydrogel useful as a contact lens material.

Abstract: The invention provides new hydrogel forming materials comprising synthetic, hydrophilic, aqueous-insoluble polymer networks formed by copolymerization of a hydrophilic dihydroxyalkyl acrylate or methacrylate, a substantially water insoluble alkyl acrylate or methacrylate, one or more additional hydrophilic comonomers selected from the group of vinylic monomers, acrylates, and methacrylates, and a cross-linking agent. The hydrogels are preferably used for the formation of contact lenses, but may also be used for drug and pesticides delivery devices; dialysis, ultrafiltration and reverse osmosis membranes; implants in surgery and dentistry; and the like.

Abstract: A method of measuring glycosylated hemoglobin featuring, in one aspect, providing a sample containing hemoglobin, including an unknown amount of glycosylated hemoglobin, contacting the sample with an oxidizing agent to generate formaldehyde, and measuring the formaldehyde as a measure of glycosylated hemoglobin, the measuring being carried out by reacting the formaldehyde with a water-soluble amine or an ammonium salt and a .beta.-diketone to generate a fluorescent compound whose fluorescence is measured as a measure of glycosylated hemoglobin.

Abstract: Compositions and processes featuring, in one aspect, a process of purifying a protein diagnostic for atherosclerosis comprising separating out of primate and human atherosclerotic tissue a Gla-containing protein of molecular weight of about 80,000.

Abstract: The invention provides a method of treating hydrogels formed from the polymerization of monomers having reactive olefinic double bonds by contacting them with reactive thiol compounds. In a preferred embodiment where the hydrogel structure includes a cis-glycol containing unit, a suitable thiol is used in conjunction with a borate buffer. The present invention also provides materials that are treated with the above thiol compounds.

Abstract: Process and apparatus for measuring glycosylated hemoglobin by assaying bound glyco groups in hemolysate featuring, in one aspect, appropriate oxidation of glycosylated hemoglobin and the rapid measurement of the resultant aldehydic compounds.

Abstract: The invention provides new hydrogel forming materials comprising synthetic, hydrophilic, aqueous-insoluble polymer networks formed by copolymerization of a hydrophilic dihydroxyalkyl acrylate or methacrylate, a substantially water insoluble alkyl acrylate or methacrylate, one or more additional hydrophilic comonomers selected from the group of vinylic monomers, acrylates, and methacrylates, and a cross-linking agent. The hydrogels are preferably used for the formation of contact lenses, but may also be used for drug and pesticides delivery devices; dialysis, ultrafiltration and reverse osmosis membranes; implants in surgery and dentistry; and the like.