Abstract: A method and apparatus for preparation of a selected area of skin to facilitate drug absorption comprises removal of the outermost layers of the skin by gentle abrasion or other means, measuring the change in electrical resistance or impedance of the skin as the outermost layers of the skin are removed, and stopping skin removal when a predetermined optimum skin resistance or impedance is achieved to facilitate drug absorption. The preferred electrical resistance or impedance meter is in contact with the skin under consideration by two separate but adjacent conductive poles and is purpose calibrated to signal when the skin resistance or impedance level is such that rapid absorption of a drug will occur.